他者の視点に立ったネガティブな記憶の捉え直しによる精神的健康の改善 : ロールレタリングを用いた予防的介入

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 高橋 美保, 東京大学教授 下山 晴彦, 東京大学准教授 滝沢 龍, 東京大学教授 遠藤 利彦, 東京大学准教授 森田 賢治University of Tokyo(東京大学

Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis

von Willebrand factor (VWF) performs its hemostatic functions through binding to various proteins. The A1 domain of VWF contains binding sites of not only physiologically important ligands, but also exogenous modulators that induce VWF-platelet aggregation. Sulfatides, 3-sulfated galactosyl ceramides, that are expressed on oligodendrocytes, renal tubular cells, certain tumor cells and platelets, have been suggested to interact with VWF under some pathological conditions. The binding of VWF to sulfatide requires the A1 domain, but its binding sites have not been precisely identified. Here, we report that alanine mutations at Arg1392, Arg1395, Arg1399 and Lys1423 led to decreased VWF–sulfatide binding. These sites have been reported to be the binding sites for platelet membrane glycoprotein (GP) Ib and/or snake venom botrocetin, and, interestingly, are identical to the monoclonal antibody (mAb) NMC4 epitope previously reported to inhibit the VWF-GPIb interaction. We observed that NMC4 also inhibited VWF interaction with sulfatides in a dose-dependent manner. Thus, we conclude that VWF binding sites of sulfatide overlap those of platelet GPIb and botrocetin

A Review of Outcome Research on Role Lettering Possibilities and Problems of the Role Letter Writing Technique in Psycho-educational Intervention for the Group of University Students

The need for intervention to prevent psychological maladaptation among university students is increasing. To provide support for as many students as possible, it is desirable that the intervention can be offered in the lecture. Besides the existing programs targeted at automatic thoughts, another form of intervention should be sought to facilitate the change in negative schemata, which are thought to generate automatic thoughts. This paper focuses on Role Lettering (letter writing technique) as a candidate for such intervention and reviews the outcome research on it to discuss its possibilities and problems in application to the psychoeducational lecture in universities

法概念の論理的分析

本研究は、多様な法概念とそれらの相互関係を、現代(非古典)論理の論理式で表現することを目標とした。本研究を通して、語用論的な法概念の構造を分析し、また、授権規範を2階の述語論理の論理式で表現できることを指摘した。さらに、道徳規範と法的権利の論理的関係についても説明した。条件法の問題や、様相と条件法の関係の問題については、今後の検討課題とした。In this study, I tried to express different concepts of Law and relations of them in logical forms of modern (non-classical) logics. Thorough this study, I analysed the structure of the pragmatic concept of law. I also pointed out a possibility to express logical forms of “norms of competence” in forms of the second order predicate logic. Furthermore, I explained a logical relation between moral norms and legal rights. Someproblems of conditionals and of relations between modalities and conditionals remained unresolved.研究課題/領域番号:21730006, 研究期間(年度):2009-201