21 research outputs found
Vineyard evaluation of stilbenoid‐rich grape cane extracts against downy mildew: a large‐scale study
Genetic analysis of stilbenoid profiles in grapevine stems reveals a major mQTL hotspot on chromosome 18 associated with disease-resistance motifs
Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells
An innovative approach to grape metabolomics: stilbene profiling by suspect screening analysis
Suspect screening analysis is a targeted metabolomics approach in which identification of compounds relies on specific available information such as their molecular formula and isotopic pattern. This method was applied to the study of grape metabolomics with an UPLC/MS high-resolution Q-TOF mass spectrometer (nominal resolution 40,000) coupled with a Jet Stream ionization source. The present paper describes the detailed qualitative and quantitative study of grape stilbenes, the principal polyphenols associated with the beneficial effects of drinking wine. With this approach, a total of 18 stilbene derivatives was identified in two grape samples (Raboso Piave and Primitivo) on the basis of accurate mass measurements and isotopic patterns, and identification was confirmed by MS/MS analysis. The approach can also potentially be applied to the metabolomics of other plant varieties
Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital
Stilbenoid-Enriched Grape Cane Extracts for the Biocontrol of Grapevine Diseases
International audienc
An innovative approach to grape metabolomics: stilbene profiling by suspect screening analysis
Vitis vinifera canes, a source of stilbenoids against Spodoptera littoralis larvae
Stilbenes are constitutively accumulated in grape canes at a high concentration of about 10 g kg(-1) DW. Some of these compounds have antimicrobial activity and are involved in grapevine defence in leaves and fruits, acting as phytoalexins. In this work, we studied their insecticidal effects against Spodoptera littoralis larvae by using an extract from grapevine canes containing 27% (w/w) of total stilbenes and the major ones isolated from this extract (E-piceatannol, E-resveratrol, isohopeaphenol, E-epsilon-viniferin and E-vitisin B). The stilbenes isolated from the grapevine extract did not show any significant antifeedant effect or acute toxicity, but they did cause chronic mortality to the larvae population of an important polyphagous pest, S. littoralis. The tetramer, E-vitisin B, appeared to be the most effective compound with LC50 and LC90 values of 134 and 298 mu g cm(-2), respectively. Significant synergic relationships were found between some stilbenes, resulting in a significant increase in the insecticidal efficacy of the mixture of these substances. Taken together, these results suggest that grapevine canes are a good source of active substances for the development of botanical insecticides