ROLE OF SHORT-TERM INTERVENTION IN THE PREVENTION OF FETAL ALCOHOL SYNDROME AND FETAL ALCOHOL SPECTRUM DISORDERS

The review of scientific literature describes modern understanding of the problem of teratogenic effect of alcohol on the fetus and pregnancy outcome. The attention is paid to the problems of incidence, the role of short-term intervention in the prevention of fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorders (FASD). It is shown that in Russia accurate epidemiological data on the incidence of fetal alcohol syndrome and fetal alcohol spectrum disorders are not available. It's noted that alcohol consumption in women can lead to adverse pregnancy outcomes. In a review of domestic and foreign literature it was revealed that in Russia there is a lack of information on violations arising in connection with the use of alcohol by child's mother during the prenatal period. FAS and FASD problem are little studied, including Irkutsk region. It was established that there was no data on the prevalence and incidence of FAS and FASD. Prevention issues are covered a bit and are used in physicians' practice not in all regions. Therefore, the study of this problem will be of great theoretical and practical significance

Lipid peroxidation and antioxidant protection systems in pregnant women consuming alcohol in small and moderate doses

The analysis of scientific researches shows that the problem of alcohol consumption (beer, dry wine, champagne), in small doses during pregnancy has been actually disregarded for many years. So the problem has become quite urgent, especially in Russia. In order to determine the effect of alcohol on pregnancy and childbirth, women and babies were divided into three groups. Group 1 (n = 101) (control group) included women who did not use alcohol during pregnancy. Group 2 (n = 75) included drinking women whose alcohol consumption during pregnancy was less than 2 doses or 750 ml. Group 3 (n = 33) included moderately drinking women whose alcohol consumption during pregnancy ranged from 3 to 11 doses (from 750 ml to 3850 ml). The study of the lipid peroxidation-antioxidant protection system as a sensitive marker of integrated health disorders in women, consuming alcoholic beverages in a prenatal period, was conducted. It was indicated that a statistically significant decrease in overall antioxidant activity was found in the context of lipid peroxidation activation in women consuming low-alcohol drinks, which demonstrates a lack of functioning of lipid peroxidation system and oxidative stress regardless of the dose of low-alcohol drinks

DISCRIMINANT ANALYSIS AS A METHOD OF DETERMINATION OF GESTATIONAL PERIOD IN DRINKING WOMEN AND HEALTH CONDITION OF THEIR NEWBORNS

The article presents the methods of mathematical analysis of the impactof alcohol on pregnancy, childbirth, postpartum and the state of health of newborn state. With the help of this analysis we revealed informative diagnostic features that let determine the effect of alcohol on pregnancy, childbirth, postpartum and newborn state: the use of alcohol before pregnancy once per month; alcohol consumption before pregnancy 2-4 times per month; smoking during pregnancy; abortion history; anemia during pregnancy; congenital heart disease on the third ultrasound screening; abnormal birth activity; subinvolution of uterus in the postpartum period; newborn gender; gestational age; prematurity and generally heavy state of a newborn. Linear classification function can be calculated by the formula 1.2. Canonical linear discriminant function can be calculated from equation [formula 3]. Diagnostic accuracy of decision rules in the middle is quite high - 76,69 %, in the first group - 75,7 %, in the second group - 77,6 %