Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions

The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic

Shape of primary proton spectrum in multi-TeV region from data on vertical muon flux

It is shown, that primary proton spectrum, reconstructed from sea-level and underground data on muon spectrum with the use of QGSJET 01, QGSJET II, NEXUS 3.97 and SIBYLL 2.1 interaction models, demonstrates not only model-dependent intensity, but also model-dependent form. For correct reproduction of muon spectrum shape primary proton flux should have non-constant power index for all considered models, except SIBYLL 2.1, with break at energies around 10-15 TeV and value of exponent before break close to that obtained in ATIC-2 experiment. To validate presence of this break understanding of inclusive spectra behavior in fragmentation region in p-air collisions should be improved, but we show, that it is impossible to do on the basis of the existing experimental data on primary nuclei, atmospheric muon and hadron fluxes.Comment: Submitted to Phys. Rev.

Comparative Assessment of Changes in the Blood Coagulation System in Rats When Exposed to Organic Boron Compounds of Various Chemical Structures

Background. Despite the available information on the clinical manifestations of acute and chronic intoxication with boron compounds, no clear evidence was found among studies to research the effect of boron compounds with different chemical structures on key factors of the blood coagulation system. The data are presented in full for the first time. Aim of the study. Identification of possible signs of the effect of boron compounds on selected indicators of hemostasis in laboratory animals and their characteristics depending on the chemical structure of the compounds. Methods. Modern methods of studying hemostasis are used. Nonlinear rats were chosen as the experimental biological model. Once through the mouth, in the maximum tolerated dose, the following drugs were administered: isopropylmethacarborane, 1,2-di(oxymethyl)orthocarborane, 1,7-di(oxymethyl)methacarborane, polyethylammonium triethylammonium salt, boric acid. Research conducted against a background of dynamic control. Results. Materials were obtained that testify to the effect of boron compounds under the conditions of this experiment on factors of the blood coagulation system. The differences in this effect are established in connection with the chemical structure of the compounds, which are especially pronounced after the introduction of methacarboranes. The effect of orthocarborane and the polyethylammonium triethylammonium salt on factors was less significant. An important fact is that boric acid per se, by its effect on the blood coagulation system, turned out to be less effective than other compared compounds. Conclusion. The polytropy of the toxic effect of boron compounds of different chemical structures was confirmed, including with the involvement of the blood coagulation system, but with the essential features of each of them under conditions of a single exposure to laboratory animals in the maximum tolerated dose

Synthesis, Structure, and Magnetic Properties of an Al2O3/Ge-p/Al2O3/Co Thin-Film System

Abstract—Structural and magnetic measurements are made of an Al2O3/Ge-p/Al2O3/Co thin-film system. The structure is synthesized via ion-plasma deposition and can be used as a tunnel heterostructure. The dependences of the magnetic properties of cobalt on the rate of its deposition and the rates of deposition of preceding layers are established

FORMATION OF RESPONSE OF ANIMALS’ ORGANISMS ON THE REPEATED ADMINISTRATION OF POLYVITAMINIC COMPLEX

The article presents the data on the appearance of significant changes in the condition of animals' organisms during quarterly daily intragastric administration, of polyvitaminic preparation of compound composition in a dose of 600 mg/kg and also on the lack of the changes at the administration in recommended, therapeutic dose. The preparation is not mutagenic

TO THE ASSESSMENT OF EFFECT OF MULTIVITAMIN COMPLEX AT THE SINGLE INTRAGASTRiC INTRODUCTION TO RATS

The article presents the results of experimental study of the biological model of single intragastric introduction of multivitamin set in different doses, which signify the response of the organism in the form of changes in a number of indices of animals condition

FORMATION OF RESPONSE OF RATS ORGANISM ON SINGLE INFLUENCE OF TERIZIDONE - 250 MG + PYRIDOXINE HYDROCHLORIDE - 10 MG

The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation

FORMATION OF RESPONSE OF RATS ORGANISM ON SINGLE INFLUENCE OF TERIZIDONE - 300 MG

The article presents the materials of experimental study of Terizidone preparation in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation