Clinico-immunological effectiveness of immunotherapy in patients with respiratory syncytial virus infection

We studied 44 patients with different complications of respiratory syncytial virus infection (bronchitis, acute tonsillitis, pneumonia). 29 patients were treated by recombinant interferon-α2b in the form of rectal suppositories (Viferon) as an addition medication to a common therapy. The results of clinical and immunological analysis showed that use of interferon in case of bronchitis or acute tonsillitis may be unreasonable, but it had relative indications in case of pneumoni

Optimizing the Intensive Care Treatment of Severe and Complicated Plasmodium falciparum Malaria in Nonimmune Patients

This study analyses the intensive care treatment of 48 patients admitted to the Intensive Care Unit (ICU) at the Infectious Diseases Clinical Hospital No. 2, Moscow, Russia, between 2007 and 2019, with a severe and complicated form of P. falciparum malaria (B50.8 ICD 10). Objective. The aim of this study was to improve the intensive care treatment for severe and complicated P. falciparum malaria. The treatment strategy implemented was aimed at preventing ischaemia-reperfusion injury to organs, as well as haemorrhagic complications. The ICU Case Management Protocol set up indications for transferring patients to the ICU which provide preventive (prior to the development of renal failure) application of extracorporeal hemocorrection methods (continuous venous-venous hemodiafiltration and plasmapheresis in a plasma exchange mode) and mechanical ventilation under a medically induced coma, given impaired consciousness as the initial symptom of patients. Results. Successful treatment outcome in a majority of the patients (93.8%), shorter ICU length of stay (6.67 ± 1.9 days as compared to 94 ± 1.6 before introduction of the protocol), a median parasite clearance time of 37.50 hours (95% CI 36.21–38.18), and a reduced mortality rate from 29.1% to 6.25% support the efficacy of the ICU protocol in managing severe and complicated P. falciparum malaria

Modern approaches to administration of enterosorbatesfor treatment of acute intestinal diseases

The condition and modern possibilities of enterosorbates's administration of various groups in complex therapy of acute bacterial and virus diarrheal disease are presented. Noted that efficacy of treatment depends on early administration of medications and the selection based on their impact on pathogenic mechanisms of disease

Blastocystis spp infections in clinical practice

Pathogenic properties of Blastocystis spp. - widespread of this protozoan organism remains debatable. Data on clinical observations demonstrating that the manifest forms of invasive Blastocystis spp . can occur from mild diarrhea, dysentery-like, to severe ulcer-necrotizing bowel perforation with complications and poor prognosis. However, one should not exaggerate the pathogenic properties of these protozoa because most infected people are asymptomatic carriers, or have symptoms of diarrhea syndrome of varying severity and duration