Verification of zinc role in pathophysiology of chronic obstructive pulmonary disease

Aim. Determination of the level of zinc and its fractions, as well as the enzyme neutrophilic elastase and albumin in persons suffering from chronic obstructive pulmonary disease (COPD), as well as smoking actively and passively. Materials and methods. The study involved 30 patients with a diagnosis of COPD and 90 healthy persons (60 of them smoking at the present time, 30 - no) who underwent spirometry and determination of zinc levels and its pools, albumin, and neutrophil elastase. All data are subject to statistical processing. Results. It is determined that the studied parameters differ significantly in the groups of smokers with COPD, healthy smokers and non-smokers, and correlate with the volume of forced exhalation for 1 second as a percentage of the due. Conclusion. The revealed regularities make it possible to consider the indicator "share of bound zinc fraction" introduced in the study as a screening criterion in diagnosing COPD in smokers

LEVEL OF ZINC AND ITS FRACTIONS AS REFLECTION OF A CONDITION OF ANTIOXIDANT SYSTEM AT THE CHRONIC OBSTRUCTIVE LUNG DISEASE

Objective. To estimate a possibility of use of zinc and its fractions as the indicator reflecting a condition of antioxidant system at sick HOBL and persons from risk groups. Materials and methods. Patients with COPD, smokers and non-smoking healthy people have participated in a research. Everything participated in a research has carried out spirometry with definition of an indicator of FEV1 and the subsequent calculation of FEV1 % of due. Taking into account importance of the occupied role when forming COPD of an oxidative stress have been determined the level of activity of the main enzyme of antitoskidantny protection — superoxide dismutases; level of zinc and its fractions as main component of enzyme and also albumine as main tranporter of metabolic active zinc. The indicator “a share of the related fraction of zinc” for definition of changes in fractions of zinc is entered. Results of the study. It is defined that at the smoking patients with the minimum malfunction of external breath of change of indicators are similar to that at patients with COPD. Statistically significant differences in the level of the studied indicators at non-smoking patients are also revealed. With use of the correlation analysis of Spirmen reliable high correlation communications between FEV1 % from due and activity level superoxide dismutases and also between activity level superoxide dismutases and the general level of zinc and also zinc connected are defined that confirms a hypothesis of a possibility of use of level of zinc and its fractions as the indicator reflecting a condition of antioxidant system at the smoking persons at screening researches

STUDYING OF COMORBID PATHOLOGY AT THE 2 TYPES DIABETES AS THE COMPLICATION OF THE METABOLIC SYNDROME

Purpose. To define features of comorbid pathology at patients with a 2 types diabetes, to estimate a possibility of use of indexes of a comorbid pathology in the management of these patients. Materials and methods. Patients with a 2 types diabetes participated in a research. The retrospective analysis of medical records with calculation of indexes of a comorbid pathology for the systems CIRS, Kaplan-Feinstein, Charlson was made. Taking into account the received indexes at patients prognostic indicators of percentage risk of lethality within the next year and 10-year survival were defined. Correlation interrelations between laboratory indicators of components of a metabolic syndrome and values of indexes of a a comorbid pathology are defined. Results. It was defined that in structure of comorbid pathology at the chosen patients diseases of cardiovascular, nervous and genitourinary systems prevail. Besides the specified systems, at women specific gravity of pathology of endocrine system is big. With age the tendency to prevalence of comorbid pathology of the specified systems remains and also the augmentation of average score of indexes of a comorbid pathology on all systems, deterioration in prognostic indicators is taped. Statistically significant direct link between indexes of a comorbid pathology and separate components of a metabolic syndrome, an experience of a disease of patients is also taped