2 research outputs found
A Study on Radiation Effect on Microvasculature of the Liver in Rat
Microarigiography of rat liver was performed with
arterial and venous infusion of barium solution to
evaluate the vascular alterations in radiation injury
of the liver in a total of 53 rats.
Part of liver, right to midline, received a single
dose of 2,000 rad using Co-60 teletherapy unit with
field size of 4 x 4cm at 60cm SSD. The dose rate
was 127.2 rads per minute.
Microangiography was performed at, 1, 2, 4, 8, 12
and 16 weeks following irradiation.
The results are as follows:
1. After irradiation, mieroangiographic findings of
hepatic artery and portal vein were tortuosity,
beaded appearance and narrowing of the lumen.
And these findings appeared at 2 to 4 weeks after
irradiation and progressed with lapse of time.
2. Hepatic vein showed no remarkable abnormality
in microangiography.
3. Sinusoids showed slight widening and irregularity.
These findings were present for the first 4 weeks
and thereafter disappeared.
4. Microangiographic findings generally well corre-lated with histologic findings.
5. In conclusion, in radiation injury of rat liver
with a single dose of 2,000rad, the principal
changes were observed in hepatic artery and
por-tal vein
An Experimental Study on Renal Artery Embolization with Ethanol
Artificial renal artery embolization was induced
using ethanol in rabbits to determine the adequate
concentration and amount of the ethanol to induce
total renal ablation.
A series of selective renal arteriography was done
immediately, 1 week and 4 weeks after infusion of
ethanol.
The results were as follows:
1. There was no visible obstruction of renal artery
after infusion of 60% ethanol 0.2ml/kg.
2. Incomplete obstruction of renal artery was
produced in majority, after infusion of 80% ethanol
0.2ml/kg.
3. Incomplete obstruction of renal artery was
produced in all cases after infusion of 8096 ethanol
0.5ml/kg.
4. Incomplete obstruction of renal artery was
produced in majority, after infusion of absolute
ethanol 0.2ml/kg, and it became complete obstruction
above half cases after 4 weeks.
5. Complete obstruction of renal artery was produced
after infusion of absolute ethanol O.5ml/kg,
in majority initially and in all cases later on.
It was considered that ethanol is an effective
agent for complete renal arterial ocelusion and O. 2
to O. 5ml/kg of absolute ethanol is effective minimal
dose for complete renal arterial occlusion