11 research outputs found

    ๋น„์œ„๋งž์ถ”๊ธฐ ํ–‰๋™ ์ฐจ์›๊ทœ๋ช… ๋ฐ ๋น„์œ„๋งž์ถ”๊ธฐ ๋ณ€์ธ, ์ˆ˜ํ–‰๋ณ€์ธ๊ณผ ์ƒ์‚ฌ-๋ถ€ํ•˜ ๊ตํ™˜ ์งˆ ๊ฐ„์˜ ๊ด€๊ณ„ : ์ง์—…๊ตฐ์ธ ์ง‘๋‹จ์„ ๋Œ€์ƒ์œผ๋กœ

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    ํ•™์œ„๋…ผ๋ฌธ(์„์‚ฌ)--์„œ์šธ๋Œ€ํ•™๊ต ๋Œ€ํ•™์› :์‹ฌ๋ฆฌํ•™๊ณผ ์กฐ์ง์‹ฌ๋ฆฌํ•™์ „๊ณต,1996.Maste

    Npas4 gene for treating or preventing mood disorders and screening methods using the same

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    ๊ธฐ๋ถ„ ์žฅ์•  ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ Npas4 ์œ ์ „์ž ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•์— ๊ด€ํ•œ ๊ฒƒ์œผ๋กœ, ์ผ ์–‘์ƒ์— ๋”ฐ๋ฅด๋ฉด, Npas4(neuronal PAS domain protein 4) ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ ์–ต์ œ์ œ๋ฅผ ์œ ํšจ์„ฑ๋ถ„์œผ๋กœ ํฌํ•จํ•˜๋Š”, ๊ธฐ๋ถ„ ์žฅ์• ์˜ ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ์šฉ ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ, ๋ฐ Npas4 ์œ ์ „์ž๋ฅผ ์ด์šฉํ•˜์—ฌ ๊ธฐ๋ถ„์žฅ์• ์˜ ์น˜๋ฃŒ์ œ๋ฅผ ์Šคํฌ๋ฆฌ๋‹ํ•˜๋Š” ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•œ๋‹ค

    Pharmaceutical composition for preventing or treating anxiety disorder comprising inhibitor of Slitrk3 and Nlgn2

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    ๋ณธ ๋ฐœ๋ช…์€ Slitrk3 ๋ฐ Nlgn2๋ฅผ ํ‘œ์ ํ•˜์—ฌ ๋ถˆ์•ˆ์žฅ์• ๋ฅผ ์น˜๋ฃŒํ•  ์ˆ˜ ์žˆ๋Š” ๊ธฐ์ˆ ์— ๊ด€ํ•œ ๊ฒƒ์œผ๋กœ, ๋ณด๋‹ค ๊ตฌ์ฒด์ ์œผ๋กœ๋Š” Slitrk3 ๋ฐ Nlgn2 ์–ต์ œ์ œ๋ฅผ ์œ ํšจ์„ฑ๋ถ„์œผ๋กœ ํฌํ•จํ•˜๋Š” ๋ถˆ์•ˆ์žฅ์•  ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ์šฉ ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ ๋ฐ ์ƒ๊ธฐ ์กฐ์„ฑ๋ฌผ์„ ํฌํ•จํ•˜๋Š” ์•ฝํ•™ ์ œ์ œ์— ๊ด€ํ•œ ๊ฒƒ์ด๋‹ค. ๋ณธ ๋ฐœ๋ช…์— ๋”ฐ๋ฅด๋ฉด ์ „์ „๋‘์—ฝ ์‹ ๊ฒฝํšŒ๋กœ์˜ ๊ตฌ์กฐ ๋ฐ ํ™œ์„ฑ์„ ์กฐ์ ˆํ•˜๋Š” ์–ต์ œ์„ฑ ์‹œ๋ƒ…์Šค์˜ ํŠน์„ฑ์„ ์„ ํƒ์ ์œผ๋กœ ์ œ์–ดํ•จ์œผ๋กœ์จ ๋ถˆ์•ˆ์ฆ์ƒ์— ๊ด€์—ฌํ•˜๋Š” ์‹ ๊ฒฝํšŒ๋กœ์— ๋Œ€ํ•œ ์ง€์‹์„ ์ œ๊ณตํ•˜๋ฉฐ, ์ƒ๊ธฐ Slitrk3 ๋ฐ Nlgn2 ์œ ์ „์ž๋Š” ๋ถˆ์•ˆ์ฆ์„ธ ๋ฐ ํ–‰ ๋™์„ ์กฐ์ ˆํ•  ์ˆ˜ ์žˆ๋Š” ์‹ ์•ฝ ๊ฐœ๋ฐœ์„ ์œ„ํ•œ ์น˜๋ฃŒํ‘œ์ ์œผ๋กœ์จ ์œ ์šฉํ•˜๊ฒŒ ์ด์šฉ๋  ์ˆ˜ ์žˆ์„ ๊ฒƒ์œผ๋กœ ๊ธฐ๋Œ€๋œ๋‹ค

    Memory impairment animal model, method for producing the same and uses thereof

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    Clstn3 (Calsyntenin 3) ์œ ์ „์ž ๋˜๋Š” ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ์ด ์–ต์ œ๋œ ๊ธฐ์–ต ์žฅ์•  ๋™๋ฌผ ๋ชจ๋ธ, ์ƒ๊ธฐ ๊ธฐ์–ต ์žฅ์•  ๋™๋ฌผ ๋ชจ๋ธ์„ ์ œ์กฐํ•˜๋Š” ๋ฐฉ๋ฒ•, ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ๊ธฐ์–ต ์žฅ์•  ์น˜๋ฃŒ์ œ์˜ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•œ๋‹ค. ์ด์— ๋”ฐ๋ฅด๋ฉด, ๊ธฐ์–ต ์žฅ์•  ์น˜๋ฃŒ์ œ์˜ ๊ฐœ๋ฐœ ๋ฐ ์Šคํฌ๋ฆฌ๋‹์— ์œ ์šฉํ•˜๊ฒŒ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ๋‹ค

    IQSEC3 gene for treating or preventing mood disorders and screening methods using the same

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    ๊ธฐ๋ถ„ ์žฅ์•  ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ IQSEC3 ์œ ์ „์ž ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•์— ๊ด€ํ•œ ๊ฒƒ์œผ๋กœ, ์ผ ์–‘์ƒ์— ๋”ฐ๋ฅด๋ฉด, IQSEC3(IQ motif and Sec7 Domain 3) ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ ์–ต์ œ์ œ๋ฅผ ์œ ํšจ์„ฑ๋ถ„์œผ๋กœ ํฌํ•จํ•˜๋Š”, ๊ธฐ๋ถ„ ์žฅ์• ์˜ ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ์šฉ ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ, ๋ฐ IQSEC3 ์œ ์ „์ž๋ฅผ ์ด์šฉํ•˜์—ฌ ๊ธฐ๋ถ„์žฅ์• ์˜ ์น˜๋ฃŒ์ œ๋ฅผ ์Šคํฌ๋ฆฌ๋‹ํ•˜๋Š” ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•œ๋‹ค

    Epilepsy animal model, method for producing the same and uses thereof

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    IQSEC3 (IQ motif and Sec7 domain 3) ์œ ์ „์ž ๋˜๋Š” ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ์ด ์–ต์ œ๋œ ๋‡Œ์ „์ฆ ๋™๋ฌผ ๋ชจ๋ธ, ์ƒ๊ธฐ ๋‡Œ์ „์ฆ ๋™๋ฌผ ๋ชจ๋ธ์„ ์ œ์กฐํ•˜๋Š” ๋ฐฉ๋ฒ•, ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ๋‡Œ์ „์ฆ ์น˜๋ฃŒ์ œ์˜ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•œ๋‹ค. ์ด์— ๋”ฐ๋ฅด๋ฉด, ๋‡Œ์ „์ฆ ์น˜๋ฃŒ์ œ์˜ ๊ฐœ๋ฐœ ๋ฐ ์Šคํฌ๋ฆฌ๋‹์— ์œ ์šฉํ•˜๊ฒŒ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ๋‹ค

    PTPฯƒ gene for treating or preventing anxiety disorders and screening methods using the same

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    ๋ณธ ์ถœ์›์€ ๋ถˆ์•ˆ ์žฅ์•  ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ๋ฅผ ์œ„ํ•œ PTPฯƒ์œ ์ „์ž ๋ฐ ์ด์˜ ์šฉ๋„์— ๊ด€ํ•œ ๊ฒƒ์œผ๋กœ์„œ, PTPฯƒ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ ์–ต์ œ์ œ๋ฅผ ์œ ํšจ์„ฑ๋ถ„์œผ๋กœ ํฌํ•จํ•˜๋Š” ๋ถˆ์•ˆ ์žฅ์• ์˜ ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ์šฉ ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ, ๋ฐ PTPฯƒ ๋‹จ๋ฐฑ์งˆ์˜ ๋ฐœํ˜„ ๋˜๋Š” ํ™œ์„ฑ ์ˆ˜์ค€์„ ์ธก์ •ํ•˜๋Š” ๋‹จ๊ณ„๋ฅผ ํฌํ•จํ•˜๋Š” ๋ถˆ์•ˆ ์žฅ์•  ์น˜๋ฃŒ์ œ๋ฅผ ์Šคํฌ๋ฆฌ๋‹ํ•˜๋Š” ๋ฐฉ๋ฒ•์„ ์ œ๊ณตํ•œ๋‹ค

    APP ๋ฐ MDGA1 ๋‹จ๋ฐฑ์งˆ ์ƒํ˜ธ์ž‘์šฉ ์–ต์ œ์ œ๋ฅผ ํฌํ•จํ•˜๋Š” ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•

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    APP ๋ฐ MDGA1 ๋‹จ๋ฐฑ์งˆ ์ƒํ˜ธ์ž‘์šฉ ์–ต์ œ์ œ๋ฅผ ํฌํ•จํ•˜๋Š” ์•ฝํ•™์  ์กฐ์„ฑ๋ฌผ ๋ฐ ์ด๋ฅผ ์ด์šฉํ•œ ์Šคํฌ๋ฆฌ๋‹ ๋ฐฉ๋ฒ•์— ๊ด€ํ•œ ๊ฒƒ์œผ๋กœ, APP ๋ฐ MDGA1์˜ ๋‹จ๋ฐฑ์งˆ ์ƒํ˜ธ์ž‘์šฉ์— ๋Œ€ํ•œ ์–ต์ œ์ œ๋Š” ๋‡Œ์‹ ๊ฒฝ๊ณ„ ์งˆํ™˜ ์˜ˆ๋ฐฉ ๋˜๋Š” ์น˜๋ฃŒ์— ์œ ์šฉํ•˜๊ฒŒ ์‚ฌ์šฉ๋  ์ˆ˜ ์žˆ์œผ๋ฉฐ, ์ด๋Ÿฌํ•œ ์ƒํ˜ธ์ž‘์šฉ์„ ์Šคํฌ๋ฆฌ๋‹ํ•˜๋Š” ๋ฐฉ๋ฒ•์„ ํ†ตํ•ด ๋‡Œ์‹ ๊ฒฝ๊ณ„ ์งˆํ™˜ ์น˜๋ฃŒ์ œ๋ฅผ ํšจ์œจ์ ์œผ๋กœ ๋ฐœ๊ตดํ•  ์ˆ˜ ์žˆ๋‹ค
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