17 research outputs found
T2 Mapping of Articular Cartilage of the Glenohumeral Joint at 3.0T in Healthy Subjects β A Feasibility Study
νμλ
Όλ¬Έ (μμ¬)-- μμΈλνκ΅ λνμ : μνκ³Ό(μμμνμ 곡), 2014. 2. μ΅μ μ.Introduction: To evaluate the feasibility of quantitative T2 mapping of the glenohumeral joint cartilage at 3.0T and to assess the T2 mapping characteristics of the normal glenohumeral joint.
Materials and Methods: This prospective study was approved by our institutional review board and written informed consent was obtained. Fifteen healthy volunteers were enrolled and underwent a multiecho spin-echo T2-weighted MR imaging of the shoulder and T2 mapping was acquired with a dedicated software. Regions of interest that covered the full thickness of the humeral cartilage and glenoid cartilage were respectively placed on an oblique coronal image to assess the mean T2 relaxation time. T2 profiles of humeral cartilage were measured from the cartilage-bone interface to the articular surface. Intraobserver agreement was analyzed using intraclass correlation coefficient (ICC).
Results: T2 maps were successfully obtained in 13 subjects (mean age, 28.6 yearsage range, 24-33 years). All 13 joints showed normal appearance on conventional T2-weighted images, without signal intensity alterations or cartilage defects. On quantitative evaluation, the mean cartilage T2 values of humeral cartilage and glenoid cartilage were 50.5 msec Β± 12.1 and 49.0 msec Β± 9.9, respectively. Intraobserver agreement was good, as determined by an ICC of 0.736. Longer T2 values were observed at the articular surface with a tendency to decrease toward the bone-cartilage interface. The mean cartilage T2 value was 69.03 msec Β± 21.2 at the articular surface and 46.99 msec Β± 19.6 at the bone-cartilage interface of the humeral head.
Conclusion: T2 mapping of the glenohumeral joint is feasible on a 3T scanner in a clinically feasible time frame. The T2 profile of the normal humeral cartilage shows a spatial variation with an increase in T2 values from the subchondral bone to the articular surface.CONTENTS
Abstract i
Contents iv
List of Figures v
Introduction 1
Materials and Methods 3
Results 8
Discussion 16
References 20
Abstract in Korean 25Maste
κ΄μ μ°κ³¨μ μ§μ°μ± κ°λ리λ μ‘°μμ¦κ° μ기곡λͺ μμ κΈ°λ²
νμλ
Όλ¬Έ (λ°μ¬)-- μμΈλνκ΅ λνμ : μνκ³Ό, 2017. 2. νμ±ν.λͺ©μ : κ΄μ μ°κ³¨μ μ§μ°μ± κ°λ리λ μ‘°μμ¦κ° μ기곡λͺ
μμ (dGEMRIC) μμ μ νκ° λ€λ₯Έ μ¬λ¬ κ°λ리λ κΈ°λ° μ‘°μμ λ₯Ό ν΅ν΄ μ»μ μΈ‘μ κ°μ λΉκ΅ν΄λ³΄κ³ Gd-DTPA2- μΈμ μ‘°μμ λ₯Ό μ¬μ©ν dGEMRIC κ²μ¬μμλ μ μμ°κ³¨κ³Ό λ³μ±μ°κ³¨μ ꡬλΆμ΄ κ°λ₯ν¨μ 보μ¬μ€μΌλ‘μ¨, Gd-DTPA2-λ₯Ό λ€λ₯Έ μ‘°μμ λ‘μ λ체 κ°λ₯μ±μ μμλ³΄κ³ μ νλ€.
λμκ³Ό λ°©λ²: λμ΄λ λΌμ§μμ μ μΆλ μ¬κ°κ³¨(n=44)μ 4κ°μ κ°λ리λ μ‘°μμ κ΅° (κ°, n=11)μ λ°°λΉνμκ³ , νλμ μ‘°μμ κ΅° μμμλ μ μμ°κ³¨ λͺ¨λΈμΈ λμ‘°κ΅°(n=3)κ³Ό λ³μ±μ°κ³¨ λͺ¨λΈμΈ νΈλ¦½μ μ²λ¦¬κ΅° (n=8)μΌλ‘ λλμλ€. μ€νμ μ¬μ©ν μ‘°μμ λ λΉμ΄μ¨μ± MRI μ‘°μμ (Gd-BT-DO3A, Gadovist), 1κ° μμ΄μ¨ μ‘°μμ (Gd-DOTA-, Dotarem), 2κ° μμ΄μ¨ μ‘°μμ (Gd-BOPTA2-, MultihanceGd-DTPA2-, Magnevist) 4κ°μ§λ‘, λͺ¨λ μΈμ°μμΆ©μμΌμμ ν¬μνμ¬ 2.5mmol/Lμ λλλ‘ μ€λΉνμλ€. μ€λΉλ λΌμ§ μ¬κ°κ³¨μ ν¬μν μ‘°μμ μ©μ‘μ μΉ¨μμν¨ μ§νμΈ 0λΆμμλΆν° 120λΆκΉμ§ 10λΆ κ°κ²©μΌλ‘ T1 map μμμ νλνμλ€. νλν T1 mapμμ μΈ‘μ ν μ‘°μμ¦κ° ν T1 κ°κ³Ό μ‘°μμ¦κ° μ T1 κ°μ μ΄μ©νμ¬ ΞR (ΞR = 1/T1Gd β 1/T10) κ°μ κ³μ°νμκ³ , μκ°μ λ°λ₯Έ ΞR κ°μ λ³νλ₯Ό λΆμνμλ€. μ¬κ°κ³¨μ safranin-O μΌμμ μννμ¬ κ΄μ μ°κ³¨ λ΄μ glycosaminoglycan contentλ₯Ό νμΈνμλ€. Safranin-O μΌμμ κ°λλ₯Ό μ λννκΈ° μνμ¬ λΉ¨κ°μ(R), λ
Ήμ(G), νλμ(B)μ κ°λ μμΉλ₯Ό μ΄μ©νμ¬ λΆμ μμ μλ κ°λ (r = R/(R2 + G2 + B2)1/2)λ₯Ό κ³μ°νμλ€. μκ°μ λ°λ₯Έ ΞR κ°μ λ³ν μμμ λΆμνλλ° μ ν νΌν© λͺ¨ν λΆμμ μ΄μ©νμμΌλ©°, κ·Έλ£Ήκ° T1κ°, ΞRκ°μ λΉκ΅μλ Student t test μ Mann-Whitney U test λ₯Ό μ΄μ©νμλ€.
κ²°κ³Ό: μ μμ°κ³¨ λμ‘°κ΅°κ³Ό λ³μ±μ°κ³¨ νΈλ¦½μ μ²λ¦¬κ΅°μ μκ°-ΞR 곑μ μ κΈ°μΈκΈ°μ μ°¨μ΄λ Gd-BOPTA2-(0.037)λ₯Ό μ΄μ©νμμ λ κ°μ₯ μ»ΈμΌλ©°, Gd-DTPA2-(0.022), Gd-DOTA-(0.018), Gd-BT-DO3A(0.011) μμΌλ‘ κΈ°μΈκΈ°μ μ°¨μ΄κ° μμμ‘λ€. Gd-DTPA2-λ₯Ό κΈ°μ€μΌλ‘ νμμ λ, Gd-BOPTA2-μμλ κΈ°μΈκΈ°μ μ°¨μ΄κ° ν΅κ³μ μΌλ‘ μ μλ―Ένκ² μ»€μ‘μΌλ©°(p<.001), Gd-BT-DO3A μμλ μ μλ―Ένκ² μμμ‘λ€ (P = .004). μ‘°μμ μΉ¨μ 90λΆνμ 120λΆν μμμμ μ»μ λ¨μΌ T1 κ°κ³Ό ΞR κ°μ κ²½μ°, 2κ°μ μμ νλ₯Ό λλ μ‘°μμ μμλ§, λμ‘°κ΅°κ³Ό νΈλ¦½μ μ²λ¦¬κ΅° κ°μ ν΅κ³μ μΌλ‘ μ μν μ°¨μ΄κ° μμλ€. Safranin-O μΌμ κ°λ (r, λΉ¨κ°μμ μλκ°λ)λ λμ‘°κ΅°(0.77Β±0.07) κ³Ό νΈλ¦½μ μ²λ¦¬κ΅° (0.46Β± 0.05) μ¬μ΄μ ν΅κ³μ μΌλ‘ μ μν μ°¨μ΄κ° μμλ€ (p<.001).
κ²°λ‘ : λμΌ λλλ‘ dGEMRIC κ²μ¬λ₯Ό μννμμ λ, 2κ°μ μμ νλ₯Ό λλ μ‘°μμ κ°, 1κ°μ μμ νλ₯Ό λλ μ‘°μμ λ λΉμ΄μ¨μ± μ‘°μμ μ λΉν΄μ μ μμ°κ³¨κ³Ό λ³μ±μ°κ³¨μ ꡬλΆν¨μ μμ΄μ λ μ°μνμλ€. 2κ°μ μμ νλ₯Ό λλ μ‘°μμ μ€μμλ μκΈ°μ΄μμ¨μ΄ λμ μ‘°μμ μΈ Gd-BOPTA2- κ° Gd-DTPA2-μ λΉν΄μ μ μμ°κ³¨κ³Ό λ³μ±μ°κ³¨ μ¬μ΄μ λμ‘°λκ° λμ, dGEMRIC κ²μ¬μμ λ체 μ‘°μμ λ‘ μ¬μ©λ μ μλ κ°λ₯μ±μ΄ μλ€.Introduction: To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA2-) as alternatives at dGEMRIC.
Materials and Methods: Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: double negative gadopentate dimeglumine (Gd-DTPA2-), double negative gadobenate dimeglumine (Gd-BOPTA2-), single negative gadoterate meglumine (Gd-DOTA-), and nonionic gadobutrol (Gd-BT-DO3A). Patellae in each group were further assigned to control (n = 3) or trypsin-treated (n = 8) groups and were immersed in GBCA solutions prepared at a concentration of 2.5 mmol/L. T1 maps were acquired at 10-minute intervals at 0β120 minutes. The difference between postcontrast R1 and precontrast R1 (ΞR) and the time-ΞR curves were plotted. Patellae were stained with safranin-O to evaluate the proteoglycan content of the cartilage. The intensity of staining was quantified by calculating the relative fraction of red (r = R/(R2 + G2 + B2)1/2) from the intensity values of red(R), green(G), and blue(B). A linear mixed-effects model was used to analyze the time-ΞR curves, and Student t tests and Mann-Whitney U tests were used to compare dGEMRIC indexes between groups.
Results: The difference in the estimated slopes of the time-ΞR curves between control and trypsin-treated groups were greatest with Gd-BOPTA2-, followed by Gd-DTPA2-, Gd-DOTA-, and Gd-BT-DO3A, with differences in the estimated slopes of 0.037, 0.022, 0.018, and 0.011, respectively. The slope difference between control and trypsin-treated groups was significantly greater with Gd-BOPTA2- (P <.001) and significantly smaller with Gd-BT-DO3A (P = .004) in comparison with that with Gd-DTPA2-. Only the GBCAs with double negative charges showed significant differences in both the T1 measured after equilibration of cartilage with GBCA solution and the ΞR at 90 and 120 minutes between the control and trypsin-treated groups. The safranin-O staining intensity (r, relative fraction of red) differed significantly between control (0.77Β±0.07) and trypsin-treated groups (0.46Β± 0.05) (p<.001).
Conclusion: Double negative GBCAs produced better contrast between normal and degenerated cartilage than did those with a single negative charge and nonionic GBCAs at the same concentration for dGEMRIC. Because Gd-BOPTA2-, a high-relaxivity GBCA, showed higher contrast than did Gd-DTPA2-, Gd-BOPTA2- may be useful as an alternative GBCA for dGEMRIC.Introduction 1
Materials and Methods 4
Results 16
Discussion 27
References 35
Abstract in Korean 43Docto
Mediating and Moderating Effects of Mindfulness between Brooding, Reflection and Depression, Psychological Well-being
λ³Έ μ°κ΅¬μμλ λ΄λΆμ΄μ μ λ°μμμμΈ λ°μΆ λ° λ°μ±μ ꡬλ³λ μ±κ²©μ κ·λͺ
νκ³ , ν΄λΉ λ³μΈλ€μ΄ μ°μΈ λ° μ¬λ¦¬μ μλ
κ°μΌλ‘ μ΄μ΄μ§λ κ³Όμ μμ λ§μμ±κΉμ μ£Όλ μν μ νμΈνκΈ° μν΄ λ§μμ±κΉμ λ§€κ° λ° μ‘°μ ν¨κ³Όλ₯Ό μ΄ν΄λ³΄μλ€. μ΄λ₯Ό μν΄ μλκΆ λ΄ 4λ
μ λν νλΆμ 292λͺ
μ λμμΌλ‘ μ°μΈκ°μ μ λν λ°μμμ, λ§μμ±κΉ, μ°μΈ, μ¬λ¦¬μ μλ
κ° μ²λλ₯Ό μ€μνμμΌλ©°, μ΄μκ°μ μ μΈν 278λͺ
μ κ²°κ³Όλ₯Ό λΆμνμλ€. κ° λ³μΈλ€ κ° κ΄κ³λ μκ΄λΆμμ ν΅ν΄ κ²ν νμμΌλ©°, κ·Έ κ²°κ³Όλ₯Ό λ°νμΌλ‘ λ°μΆ λ° λ°μ±κ³Ό μ°μΈ λ° μ¬λ¦¬μ μλ
κ°κ³Ό κ΄κ³μμ λ§μμ±κΉμ λ§€κ° λ° μ‘°μ ν¨κ³Όμ λν΄ κ΅¬μ‘°λ°©μ μ λͺ¨νκ²μ¦μ ν΅ν΄ νμΈνμλ€. λΆμκ²°κ³Ό, λ§μμ±κΉμ λ°μΆμ μ°μΈ λ° μ¬λ¦¬μ μλ
κ°κ³Όμ κ΄κ³μμ λΆλΆλ§€ κ°μν μ, λ°μ±κ³Ό μ¬λ¦¬μ μλ
κ°κ³Όμ κ΄κ³μμ μμ 맀κ°μν μ νλ κ²μΌλ‘ λνλ¬λ€. λν λ°μΆμ μ°μΈμ κ΄κ³μμλ λ§μμ±κΉμ μ‘°μ ν¨κ³Όκ° μ μνμ¬ λ§μμ±κΉ μμ€μ΄ λμμλ‘ λ°μΆκ° μ°μΈμ λ―ΈμΉλ λΆμ μ μΈ μν₯μ΄ μ‘°μ λ¨μ νμΈ νμλ€. λ λͺ¨νμ λΉκ΅κ²°κ³Ό, λ§μμ±κΉμ μ‘°μ ν¨κ³Όλ³΄λ€ 맀κ°ν¨κ³Όμμ ν΅κ³μ μΌλ‘ μ μν κ²½λ‘κ° μ£Όλ‘ κ΄μ°°λμλ€. λ³Έμ°κ΅¬κ²°κ³Όλ₯Ό ν΅ν΄ λ°μΆ λ° λ°μ±μ΄ μ¬λ¦¬μ 건κ°μ μ΄λ₯΄λ κ³Όμ μμ κΈ°μ μ λ³νκ³Όμ μ μΌκΈ°νλ λ§μμ±κΉμ μν μ νμΈνμκ³ , νΉν λͺ¨νΈν λ°μ±μ μ±κ²©μ κ·λͺ
νμλ€. λμΌλ‘, λ³Έ μ°κ΅¬μ μμμ μ νμ μ λ
Όμνμλ€