Chewing function as contributor to active ageing

One of the main goals of dentistry is to preserve healthy masticatory function throughout life. Recent studies have shown that mastication is of great importance, not only for food intake but also for the systemic, mental and physical functions. The human masticatory apparatus is involved in various bodily functions such as chewing, swallowing, digestion, respiration, speech, non-verbal communication, and most likely interrelates with other systemic actions, including locomotion, blood circulation, excretion, endocrine function. Masticatory dysfunction may, therefore, cause disability in multiple mental and physical behavior or general health. Previous surveys conducted in Japan showed that that senior citizens who were able to chew with their own teeth could maintain daily life by themselves, whereas those without teeth or dentures had difficulty in managing daily living by themselves or were even bedridden. Furthermore, tests using experimental animals showed that stimulation induced by mastication affected satiety satisfaction by increasing nervous histamine from the satiety control center of the brain. This histamine release was also associated with better learning ability through masticatory stimulation of the chemical substance that controls memory. It was also suggested that mastication stimulates the brain and accelerates its energy-consuming metabolism. Taken together, these findings are strong indicators that oral health does not merely mean a condition without dental caries, periodontal diseases or malocclusion, but oral health should be reevaluated in connection with longer term active ageing

モノクローナル抗体のリンパ球活性化機構の解析および癌化学療法への応用

Tohoku University課

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