分子印迹聚合物在磺胺类抗生素残留检测中的 样品前处理应用研究进展

The residues of sulfonamides (SAs) antibiotics cause great harm to organisms and environments. Appropriate sample pretreatment is usually imperative to couple with chromatography / mass spectrometry analysis for the sensitive determination of SAs, ow ing to their low level residues and multiple categories presence in complicated matrices. Molecularly imprinted polymers (MIPs) have the binding sites complementary to the template molecules in shape, size and functional groups. So, MIPs can selectively recognize and effectively enrich target analytes (template) as well as eliminate matrices interferences. Thereby they have been widely applied in the sample pretreatment of SAs antibiotics. In this review, recent advances in sample pretreatment applications of MIPs for determination of SAs residues are summarized, mainly including conventional packed solid-phase extraction (PSPE), dispersive solid-phase extraction (DSPE), magnetic solid-phase extraction (MSPE) and temperature sensitive solid-phase extraction (TSPE). Several challenge is sues of MIPs are given, and some new imprinting technologies and strategies for preparation of MIPs towards SAs are highlighted, such as surface imprinting technology, nanoimprinting technology and molecularly imprinted membrane technology, as well as multi-template imprinting strategy and dummy imprinting strategy. Finally, an outlook on the preparation and pretreatment application of SAs-MIPs is proposed.</p

Applications of molecularly imprinted polymers for determination of antibiotics residues

Abuse of antibiotics as well as antibiotic residues cause great harm to living beings and the environment. However, determination of antibiotics is quite difficult owing to the low residue level and multiple categories presence in the complicated matrices. Proper sample pre- treatment is usually imperative for coupling with chromatographic analysis toward the sensitive determination of antibiotic residues. Molecularly imprinted polymers (MIPs) possess the binding sites complementary to the target (template) molecules in shape, size, and type of functional groups. Hence, MIPs can selectively recognize and effectively enrich the target analytes as well as eliminate matrix interferences. For this reason, they have been widely applied in the sample pretreatment of antibiotics. In this review, several challenges encountered with the use of MIPs and the possible solutions are proposed. Besides, advances in the applications of MIPs for the sample pretreatment of antibiotics since 2016 are summarized, mainly including conventional solid phase extraction (SPE), dispersive solid phase extraction (DSPE), magnetic solid phase extraction (MSPE), matrix solid phase dispersion (MSPD), solid phase microextraction (SPME) and stir bar sorptive extraction (SBSE). Some new imprinting strategies for the prepa- ration of MIPs to be used in the field of antibiotics are highlighted, such as multi-template imprinting, multi-functional monomer imprinting, dummy imprinting, stimuli-responsive imprinting and hydrophilic imprinting. Finally, an outlook on the preparation and pretreatment application of MIPs for antibiotics is presented

Synchronization of Complex Dynamical Combat Network with Time-Varying Coupling Strength

基于Gaussian09W软件,采用密度泛函理论(Density Functional Theory,DFT)的B3LYP方法,在6-311G(d)基组水平上优化了一种香豆素3,4-并六元杂环衍生物分子的结构,得到其最稳定构型、分子能量及HOMO、LUMO轨道能量。在优化结构的基础上,用同样的方法计算了该分子的振动频率,频率分析证明了该优化结构为最稳定结构。利用分子的振动频率数据绘制了标题分子的红外光谱图,对其红外光谱峰位进行了归属

Recent advances in applications of fragment/dummy molecularly imprinted polymers

Molecularly imprinted polymers (MIPs) are designed to mimic the specific binding principle of enzymes to substrates or antigens to antibodies,while holding several advantages such as structure predictability,recognition specificity,easy preparation,low cost,high physical robustness,and thermal stability.Therefore,they have been widely applied in many fields including sample preparation (pretreatment),sensing analysis (chemo/biosensors),biomedicine,and environment/food analysis.To date,several strategies were developed for MIPs preparation,aiming to simplify the preparation process and/or improve the properties of the polymers,greatly broadening its usability.The exploration in various advanced imprinting strategies and their combinational use has become a research hotspot in MIPs preparation,among which the fragment imprinting strategy and the dummy template imprinting strategy are especially favored.Fragment imprinting,also called segment imprinting,uses a partial structure of the target molecule as a pseudo-template to prepare MIPs.This strategy is useful to target molecules that are not easy to obtain or that are too large to be used as templates,providing a feasible method for imprinting target analytes that are easy to inactivate or infect,as well as macromolecules that are difficult to imprint.In turn,dummy template imprinting uses molecules with structure,shape,and size similar to the target analytes as templates for imprinting.Because the target is not directly used as a template,this strategy can overcome problems of template leakage,as well as solve target molecule-related difficulties as they can be expensive,infectious,flammable,explosive,or chemically instable.This mini-review compiles information of several articles published in the last four years across ACS,Elsevier,RSC,and other databases,summarizing the most recent advances in the application of fragment/dummy template MIPs (FMIPs/DMIPs).Herein,the biomedical application of FMIPs is mainly addressed as a strategy for the detection of proteins and microorganisms,and the application of FMIPs in the field of food analysis is also explored.In recent years,the imprinting of mammalian cells has made some progress in the application of FMIPs.Mammalian cells,especially cancer cells,overexpress some proteins and sugars,which are good fragment templates.Consequently,the fragment imprinting strategy is widely used in cancer cell imaging,localization,and treatment.Moreover,due to the complicated structure and easy inactivation of some proteins,their MIPs are often prepared by fragment imprinting (also called epitope imprinting).As some microorganisms are infectious,imprinting microorganisms directly can pose a risk;therefore it is safer to also use the fragment imprinting strategy in such cases.The recent application of fragment imprinting strategy in other areas remains scarce.Nonetheless,three studies in the food analysis have explored this possibility.DMIPs are widely used in sample pretreatment and sensing analysis,and they are mainly used as SPE adsorbents for packed SPE,dispersive SPE (DSPE),magnetic SPE (MSPE),and matrix solid phase dispersion (MSPD) extraction.In addition,DMIPs are employed as molecularly imprinted membrane materials.As a result,by virtue of DMIPs,selective extraction and enrichment of target analytes from complicated samples can be achieved.MIP-based sensors can either recognize or transduce,meaning that they can specifically recognize and bind target analytes as well as generate output signals for detection.Because of the high selectivity of MIPs,the use of a dummy template imprinting strategy solves the problem of template leakage in the process of recognition and adsorption,further improving the detection accuracy and sensitivity of the sensor.These features expand the application range of MIP-based sensors

Numerical simulation on solid particle erosion of solid-liquid two-phase fluid in flow controller

建立了考虑颗粒碰撞的颗粒冲蚀计算模型,该数学模型包括:在Eulerian坐标系下求解连续相流场;在Lagrangian坐标系下运用离散颗粒硬球模型求解颗粒碰撞;应用半实验关联式求解颗粒冲蚀速率。对水力加砂压裂施工中节流器内液-固两相流的固体颗粒运动和冲蚀特性进行了数值模拟。计算结果表明,固体颗粒密集于节流器入口到出口的一段狭长区域内,冲蚀速率随流体速度呈指数性变化。颗粒直径越大,冲蚀速率也越大。节流器内冲蚀最严重的位置发生在距离节流器出口上边缘10mm以内的局部区域

Rotary micro-fluidic cloth/paper composite chip for detecting lead and mercury ions and preparation method thereof

本发明公开了一种检测铅汞离子的旋转微流控布/纸复合芯片及其制备方法，其中，该复合芯片由底部传感器层、中间层、顶部取样层、铅离子印迹荧光传感布和汞离子印迹荧光传感布组成，前三者均由印有疏水图样的滤纸制成且从下至上依次叠装，底部传感器层上具有检测区，中间层的亲水通道与检测区匹配，顶部取样层的亲水采样区整体呈“V”字形且与亲水通道匹配，相邻两个亲水采样区之间开有探测孔；后两者分别由接有汞离子印迹或接有铅离子印迹的布块制成，均贴于底部传感器层的检测区且间隔排布。本发明开发出的旋转微流控布/纸复合芯片，很好地结合了纸芯片与布的特点，并且使用方便、能够特异性的灵敏检测铅汞离子

Research on the Progress of Syntheses and Application of Carbon Nitride(C3N4) Materials

作为理论预测的新材料,C3N4具有良好的物理、化学性质及广泛的应用前景,其合成和应用研究引起了国内外研究人员的关注。本文主要介绍了采用电化学沉积法、离子束溅射法和爆炸冲击合成法制备C3N4材料,并总结了C3N4材料的应用研究进展

基于微流控的海洋监测技术

In the process of recognizing the laws of the ocean, developing the marine economy, protecting and restoring the marine ecological environment, marine analysis and monitoring are essential technologies. Modern ocean monitoring presents the characteristics of in-situ, on-site, and comprehensive, and requires analysis and monitoring equipment to be small, sensitive, rapid, and automated. Microfluidic chip technology, with its outstanding characteristics of micro channel control, low-cost, and high throughput, combined with advanced chemical analysis methods, has shown excellent prospects in the construction of core sensing components of marine analysis and monitoring equipment. In this review, starting from the manufacture of microfluidic chips and the construction of analysis methods, the typical objects of marine monitoring were classified, involving pH, dissolved oxygen, nutrients, heavy metals, organic pollutants and marine microorganisms. The progress of application research in monitoring was reviewed, and its future development was prospected