2 research outputs found
Clinical Characteristics of Patients with Spondyloarthritides and HLA-B27 Positive Antigen
The aim of this study was to present our experiences in diagnosing spondyloarthritides (SpA), and to list the most
common clinical features of HLA-B 27 positive patients.The study included 65 HLA-B 27 positive patients with confirmed
diagnosis of ankylosing spondylitis(AS) and psoriatic arthritis (PsA) who were analyzed between 2009 and 2010
in Clinic of Internal Medicine in Osijek. The diagnosis of seronegative spondyloarthritides was based on the ASAS (Assessment
in AS Working Group) classification criteria for axial and then supplemented with ASAS criteria for peripheral
SpA and was confirmed by radiological techniques. For diagnosing the ankylosing spondylitis (AS), there have been
applied the modified New York criteria. Radiological criteria for definite sacroiliitis according to the modified New York
criteria is bilateral sacroiliitis, grade 2ā4 (2) or unilateral sacroiliitis, grade 3ā4. For diagnosing the psoriatic arthritis
(PsA), there were used CASPAR diagnostic criteria. Other features of SpA are defined within the existing classification
criteria. HLA-B27 antigen was determined by direct immune-fluorescence technique using flow cytometer. The average
age of patients was 50.34 years, of whom 27 female (41.53%), 38 male (58.46%). Duration of illness was 15.79 years on
average.With 75.38% of patients, there had been determined the diagnosis of AS; 24.62% of patients had the diagnosis of
PsA. The most common clinical characteristics that patients had were: inflammatory back pain (pain Inflammation along
the lumbosacral spine), peripheral arthritis, intermittent pain in the gluteus, sacroiliitis, enthesitis, uveitis, dactilitis
KliniÄka obilježja pacijenata sa spondiloartritisima i hla-b27 pozitivnim antigenom
The aim of this study was to present our experiences in diagnosing spondyloarthritides (SpA), and to list the most common clinical features of HLA-B 27 positive patients.The study included 65 HLA-B 27 positive patients with confirmed diagnosis of ankylosing spondylitis(AS) and psoriatic arthritis (PsA) who were analyzed between 2009 and 2010 in Clinic of Internal Medicine in Osijek. The diagnosis of seronegative spondyloarthritides was based on the ASAS (Assessment in AS Working Group) classification criteria for axial and then supplemented with ASAS criteria for peripheral SpA and was confirmed by radiological techniques. For diagnosing the ankylosing spondylitis (AS), there have been applied the modified New York criteria. Radiological criteria for definite sacroiliitis according to the modified New York criteria is bilateral sacroiliitis, grade 2ā4 (2) or unilateral sacroiliitis, grade 3ā4. For diagnosing the psoriatic arthritis (PsA), there were used CASPAR diagnostic criteria. Other features of SpA are defined within the existing classification criteria. HLA-B27 antigen was determined by direct immune-fluorescence technique using flow cytometer. The average age of patients was 50.34 years, of whom 27 female (41.53%), 38 male (58.46%). Duration of illness was 15.79 years on average.With 75.38% of patients, there had been determined the diagnosis of AS; 24.62% of patients had the diagnosis of PsA. The most common clinical characteristics that patients had were: inflammatory back pain (pain Inflammation along the lumbosacral spine), peripheral arthritis, intermittent pain in the gluteus, sacroiliitis, enthesitis, uveitis, dactilitis.Cilj ovog rada bio je prikazati naÅ”a iskustva u dijagnostici spondiloartritisa (SpA) te navesti najtipiÄnija kliniÄka obilježja HLA-B27 pozitivnih bolesnika. U istraživanju je ukljuÄeno 65 HLA-B 27 pozitivnih bolesnika s potvr|enom dijagnozom ankilozantnog spondilitisa (AS) i psorijatiÄnog artritisa (PsA) koji su tijekom 2009 i 2010 godine lijeÄeni na Internoj klinici u Osijeku. Dijagnoza seronegativnih spondiloartritisa temeljila se na ASAS (Assessment in AS working group) klasifikacijskim kriterijima za aksijalni i periferni SpA i bila potvr|ena radioloÅ”kim metodama. Za dijagnosticiranje ankilozantnog spondilitisa (AS) primijenili su se modificirani New york kriteriji. RadioloÅ”ki kriterij za definitivni sakroileitis prema modificiranim New York kriterijima je bilateralni sakroiliitis stupnja 2ā4 (2) ili unilateralni sakroiliitis stupnja 3ā4. Za dijagnozu psorijatiÄnog artritisa (PsA) koriÅ”teni su CASPAR dijagnostiÄki kriteriji. Ostale znaÄajke SpA definirane su u sklopu postojeÄih klasifikacijskih kriterija. HLA-B27 antigen je odreÄivan je direktnom imunofluorescentnom metodom na protoÄnom citometru. ProsjeÄna starost pacijenata bila je 50,34 godina, od kojih je 27 žena (41,53%), 38 muÅ”kih (58,46%). Trajanje bolesti bilo je u prosjeku 15,79 godina. U 75,38 % bolesnika postavljena je dijagnoza AS; 24.62% bolesnika imalo je dijagnozu PSA. NajÄeÅ”Äe kliniÄke karakteristike koje su pacijenti imali bili su: upalna križobolja (inflamatorna bol duž lumbosakralnog dijala kralježnice), periferni artritis, naizmjeniÄna bol u gluteusima, sakroiliitis, entezitis, uveitis, daktilitis. Ovo naÅ”e istraživanje je pokazalo da se kliniÄke znaÄajke HLA B 27 pozitivnih pacijenata sa SpA u IstoÄnoj Slavoniji ne razlikuju od kliniÄkih manifestacija pacijenata sa SpA u drugim dijelovima Europe koje su iznesene u razliÄitim studijama