455 research outputs found

    Teaching Power as an Inconvenient but Imperative Dimension of Critical Leadership Development

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    A central focus of critical leadership development involves identifying and understanding how power flows through society. This requires a complex understanding of social systems. This chapter explores how leadership educators can more explicitly integrate learning related to power dynamics into leadership development initiatives.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144248/1/yd20299_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144248/2/yd20299.pd

    Articulated learning trajectories related to the development of algebraic thinking that follow from patterning concepts in middle grades mathematics

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    Title from PDF of title page (University of Missouri--Columbia, viewed on May 27, 2010).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Dissertation advisor: Dr. Douglas A. Grouws.Vita.Ph. D. University of Missouri--Columbia 2010.The construct of an articulated learning trajectory (ALT) was conceived of and defined to provide a lens through which to view and analyze content development in middle grades mathematics textbooks. The ALTs identified and described were used to characterize the development of patterning and sequence concepts as they relate to algebraic thinking in four middle grades textbook series. The perspectives of clarity, comprehensiveness, accuracy, depth of mathematical inquiry and reasoning, organization, and balance were considered in analyzing the mathematical development of these concepts. Comparisons based on the disciplinary perspectives showed key differences among the ALTs identified across textbooks, including the extent to which authors presented patterns in geometric versus numeric contexts. Mathematical sequences were not well defined in any of the textbook series. The nature of the ALTs identified and the differences in the ALTs across textbook series have implications for the development of pattern concepts leading to algebraic thinking.Includes bibliographical references

    Intended Mathematics Curriculum as Represented in State-Level Curriculum Standards: Consensus or Confusion?

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    Full Report published by: Information Age Publishers. http://www.infoagepub.comThis report represents the first detailed analysis of the grade placement of particular learning goals across all state-level curriculum documents published and current as of May 2005. The report documents the current situation regarding grade-level mathematics curriculum specification in the U.S. and highlights a general lack of consensus across states. As states continue to work to improve learning opportunities for all students, we hope this report will serve as a useful summary to inform future curriculum decisions.This report is based on the work of the Center for the Study of Mathematics Curriculum, supported by the National Science Foundation under Grant No. ESI-0333879. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation

    Ebola in great apes – current knowledge, possibilities for vaccination and the implications for conservation and human health

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    Ebola virus disease (EVD) is a threat to human health and the survival of African great apes. The disease has led to major population declines of chimpanzees and gorillas, and infected great apes play an important role as sources of human EVD outbreaks. The threat posed by EVD raises the question whether vaccination of wild apes is a possible strategy to reduce the occurence and impact of this disease. This article reviews the current knowledge about EVD in great apes and emphasizes the link between ape and human outbreaks. It discusses the need for control strategies such as vaccination and describes aspects of primate behavior, virus biology, vaccine composition, and vaccination principles that are necessary to consider when making management decisions about great ape vaccination. Finally, it identifies gaps in the understanding of Ebola ecology and highlights surveillance and research that can aid the survival of great apes and reduce human exposure to Ebola virus. The unpredictable emergence of Ebola viruses and the severe impact of EVD call for efficient monitoring and ultimately control of Ebola. This article provides a platform for further interdiciplinary discussions to decide on optimal management solutions regarding vaccination of great apes against Ebola

    Malignant ovarian germ cell tumors in pediatric patients: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) study

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    Objective: Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment-related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT. Methods: Patients were treated according to their stage: surgery and surveillance for stage I; a modified bleomycin\u2013etoposide\u2013cisplatin (BEP) regimen for stages II (three cycles), III, and IV (three cycles) with surgery on residual disease. Results: Seventy-seven patients were enrolled (median age 11.8 years), 26 with dysgerminoma (Dysg), 13 with immature teratoma and elevated serum alpha-fetoprotein levels (IT+AFP), and 38 with nondysgeminoma (Non-Dysg) staged as follows: 27 stage I, 13 stage II, 32 stage III, 5 stage IV. Among evaluable patients in stage I (5-year event-free survival [EFS] 72.1% [95% CI: 56.4\u201392.1%]; 5-year overall survival [OS] 100%), seven relapsed (three patients with Dysg and four patients with Non-Dysg) and were rescuedwith chemotherapy (plus surgery in three patients). Among the evaluable patients with stages II\u2013IV, 48 (98%) achieved complete remission after chemotherapy \ub1 surgery, one (IT + AFP, stage IV) had progressive disease. In the whole series (median follow-up 80 months), the 5-year OS and EFS were 98.5% (95% CI: 95.6\u2013100%) and 84.5% (95% CI: 76.5\u2013 93.5%). Conclusions:We confirm the excellent outcome for MOGCT. Robust data are lacking on surgical staging, surveillance for Non-Dysg with stage I, the management of IT + AFP, and the most appropriate BEP regimen. As pediatric oncologists,we support the role of surveillance after proper surgical staging providing cases are managed by experts at specialized pediatric centers

    Antibodies to Nipah-Like Virus in Bats (Pteropus lylei), Cambodia

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    Serum specimens from fruit bats were obtained at restaurants in Cambodia. We detected antibodies cross-reactive to Nipah virus by enzyme immunoassay in 11 (11.5%) of 96 Lyle’s flying foxes (Pteropus lylei). Our study suggests that viruses closely related to Nipah or Hendra viruses are more widespread in Southeast Asia than previously documented

    Erythrocyte G Protein as a Novel Target for Malarial Chemotherapy

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    BACKGROUND: Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte G(s) signaling blocked invasion by the human malaria parasite Plasmodium falciparum. METHODS AND FINDINGS: We investigated the erythrocyte guanine nucleotide regulatory protein G(s) as a novel antimalarial target. Erythrocyte “ghosts” loaded with a G(s) peptide designed to block G(s) interaction with its receptors, were blocked in β-adrenergic agonist-induced signaling. This finding directly demonstrates that erythrocyte G(s) is functional and that propranolol, an antagonist of G protein–coupled β-adrenergic receptors, dampens G(s) activity in erythrocytes. We subsequently used the ghost system to directly link inhibition of host G(s) to parasite entry. In addition, we discovered that ghosts loaded with the peptide were inhibited in intracellular parasite maturation. Propranolol also inhibited blood-stage parasite growth, as did other β(2)-antagonists. β-blocker growth inhibition appeared to be due to delay in the terminal schizont stage. When used in combination with existing antimalarials in cell culture, propranolol reduced the 50% and 90% inhibitory concentrations for existing drugs against P. falciparum by 5- to 10-fold and was also effective in reducing drug dose in animal models of infection. CONCLUSIONS: Together these data establish that, in addition to invasion, erythrocyte G protein signaling is needed for intracellular parasite proliferation and thus may present a novel antimalarial target. The results provide proof of the concept that erythrocyte G(s) antagonism offers a novel strategy to fight infection and that it has potential to be used to develop combination therapies with existing antimalarials