44 research outputs found

    La rendicontazione sociale d'impresa. Il caso Vodafone.

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    La responsabilitĂ  sociale d'impresa e i suoi principi di base. Modelli di riferimento della responsabilitĂ  sociale a livello internazionale e nazionale. Il bilancio sociale e il caso Vodafone

    Making forest monitoring cheaper and closer to society: The LIFE+ Project "SMART4Action"

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    LIFE SMART4Action (Sustainable Monitoring And Reporting To Inform Forest- and. Environmental Awareness and Protection. LIFE13 ENV/IT/000813) intends to redesign forest monitoring and its information and reporting system in Italy. It is designed over the period September 2014 - March 2018 and will attempt to ensure financial sustainability to forest monitoring, despite budget restrictions, whilst maintaining scientific reliability. The project has two main goals: . design a new system to reduce the current annual costs by 30%, while recognizing the importance of national and regional statistics on key variables linked to sustainable forest management and ecosystem services; and . to improve communication with, and data transfer to, relevant stakeholders and citizens through a participatory process. The analysis of the available data series of forest monitoring data will permit to optimize the number of plots, the frequency and the distribution of the activities, to maximize the information, and identify possible areas were monitoring and modeling can be fruitfully integrated. To increase awareness about forest related issues and the importance of forest monitoring, SMART4Action will develop mechanisms to involve local people in plot management and basic monitoring for readily measurable variables, with local conferences and courses, synthetic result sheets at regional scale, and web-based and smartphone applications to obtain an active involvement of citizens. Present and historical monitoring data will also be shared online using geospatial standard services. Here, we intend to present the project at its very beginning in order to explore the possibility of interaction and synergy with other on-going activities

    Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion

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    Introduction: Obesity and psychosocial stress (PS) co-exist in individuals of Western society. Nevertheless, how PS impacts cardiac and hippocampal phenotype in obese subjects is still unknown. Nor is it clear whether changes in local brain-derived neurotrophic factor (BDNF) account, at least in part, for myocardial and behavioral abnormalities in obese experiencing PS. Methods: In adult male WT mice, obesity was induced via a high-fat diet (HFD). The resident-intruder paradigm was superimposed to trigger PS. In vivo left ventricular (LV) performance was evaluated by echocardiography and pressure-volume loops. Behaviour was indagated by elevated plus maze (EPM) and Y-maze. LV myocardium was assayed for apoptosis, fibrosis, vessel density and oxidative stress. Hippocampus was analyzed for volume, neurogenesis, GABAergic markers and astrogliosis. Cardiac and hippocampal BDNF and TrkB levels were measured by ELISA and WB. We investigated the pathogenetic role played by BDNF signaling in additional cardiac-selective TrkB (cTrkB) KO mice. Findings: When combined, obesity and PS jeopardized LV performance, causing prominent apoptosis, fibrosis, oxidative stress and remodeling of the larger coronary branches, along with lower BDNF and TrkB levels. HFD/PS weakened LV function similarly in WT and cTrkB KO mice. The latter exhibited elevated LV ROS emission already at baseline. Obesity/PS augmented anxiety-like behaviour and impaired spatial memory. These changes were coupled to reduced hippocampal volume, neurogenesis, local BDNF and TrkB content and augmented astrogliosis. Interpretation: PS and obesity synergistically deteriorate myocardial structure and function by depleting cardiac BDNF/TrkB content, leading to augmented oxidative stress. This comorbidity triggers behavioral deficits and induces hippocampal remodeling, potentially via lower BDNF and TrkB levels. FUND: J.A. was in part supported by Rotary Foundation Global Study Scholarship. G.K. was supported by T32 National Institute of Health (NIH) training grant under award number 1T32AG058527. S.C. was funded by American Heart Association Career Development Award (19CDA34760185). G.A.R.C. was funded by NIH (K01HL133368-01). APB was funded by a Grant from the Friuli Venezia Giulia Region entitled: Heart failure as the Alzheimer disease of the heart; therapeutic and diagnostic opportunities . M.C. was supported by PRONAT project (CNR). N.P. was funded by NIH (R01 HL136918) and by the Magic-That-Matters fund (JHU). V.L. was in part supported by institutional funds from Scuola Superiore Sant\u27Anna (Pisa, Italy), by the TIM-Telecom Italia (WHITE Lab, Pisa, Italy), by a research grant from Pastificio Attilio Mastromauro Granoro s.r.l. (Corato, Italy) and in part by ETHERNA project (Prog. n. 161/16, Fondazione Pisa, Italy). Funding source had no such involvement in study design, in the collection, analysis, interpretation of data, in the writing of the report; and in the decision to submit the paper for publication

    REGIONAL MAPPING OF MYOCARDIAL HIBERNATION PHENOTYPE IN IDIOPATHIC END-STAGE DILATED CARDIOMYOPATHY

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    Myocardial hibernation (MH) is a well-known feature of human ischaemic cardiomyopathy (ICM), whereas its presence in human idiopathic dilated cardiomyopathy (DCM) is still controversial. We investigated the histological and molecular features of MH in left ventricle (LV) regions of failing DCM or ICM hearts. We examined failing hearts from DCM (n = 11; 41.9 ± 5.45 years; left ventricle-ejection fraction (LV-EF), 18 ± 3.16%) and ICM patients (n = 12; 58.08 ± 1.7 years; LVEF, 21.5 ± 6.08%) undergoing cardiac transplantation, and normal donor hearts (N, n = 8). LV inter-ventricular septum (IVS) and antero-lateral free wall (FW) were transmurally (i.e. sub-epicardial, mesocardial and sub-endocardial layers) analysed. LV glycogen content was shown to be increased in both DCM and ICM as compared with N hearts (P < 0.001), with a U-shaped transmural distribution (lower values in mesocardium). Capillary density was homogenously reduced in both DCM and ICM as compared with N (P < 0.05 versus N), with a lower decrease independent of the extent of fibrosis in sub-endocardial and sub-epicardial layers of DCM as compared with ICM. HIF1-α and nestin, recognized ischaemic molecular hallmarks, were similarly expressed in DCM-LV and ICM-LV myocardium. The proteomic profile was overlapping by ~50% in DCM and ICM groups. Morphological and molecular features of MH were detected in end-stage ICM as well as in end-stage DCM LV, despite epicardial coronary artery patency and lower fibrosis in DCM hearts. Unravelling the presence of MH in the absence of coronary stenosis may be helpful to design a novel approach in the clinical management of DCM

    Tako-Tsubo syndrome in patients with COVID-19: a single centre retrospective case series

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    Growing evidence shows that COVID-19 is associated with an increase in Tako-Tsubo syndrome (TTS) incidence. We collected data from patients hospitalized in our multidisciplinary COVID-19 department who had a diagnosis of TTS during the second and third wave of the pandemic in Italy. We reported four cases of TTS associated with COVID-19. No patient had any classical trigger for TTS except for COVID-19. Mean age was 72 years (67-81) and all patients had a SARS-CoV-2-related interstitial pneumonia confirmed by computed tomography. Typical apical ballooning and transitory reduction in left ventricle (LV) systolic function with a complete recovery before discharge were observed in all patients. The mean LV ejection fraction (LVEF) at TTS onset was 42% (40-48%). ECG showed ST-segment elevation in two cases, while an evolution with negative T waves and QTc prolongation was observed in all patients. Three patients underwent coronary angiography. Two patients had Alzheimer’s disease. The time interval from hospital admission to TTS onset was 4 (2-6) days, and the time interval from COVID-19 symptom onset to TTS diagnosis was 10 (8-12) days.  COVID-19 may be a trigger for TTS, though TTS pathophysiology in COVID-19 patients remains unclear, likely due to its multifactorial nature

    Influencer Marketing: indagine su percezioni e opinioni dei follower e degli utenti. Il caso Instagram.

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    L'avvento dei social media, come Instagram, Facebook, Twitter, ecc. ha portato molti cambiamenti nella vita quotidiana di molte persone. Si pensi alla modalitĂ  con cui ci relazioniamo con gli altri, a come otteniamo informazioni, e molto altro ancora. Essendo io stessa un'utente di queste piattaforme, sono venuta a conoscenza della nascita e crescita di particolari figure: gli Influencer. Questi ultimi appartengo ad una branchia del marketing, denominata Influencer Marketing: la forza di tale pratica risiede nella percezione che i consumatori hanno del soggetto con cui stanno dialogando. In particolare, attraverso il questionario, ho compreso e approfondito come gli utenti e i follower interagiscono con queste figure influenti

    Mechanical Properties and Biological Interaction of Aortic Clamps. Are These All Minimally Invasive?

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    Objective: Although specifically designed aortic clamps are mainstay of minimally invasive cardiac surgery, so far, no comparative reports about their mechanical properties and interaction with the aortic wall have been reported. In this study, the generated force in the clamps’ jaws and the biological response of the aorta after clamping are evaluated. Methods: The jaw force of five commercially available clamps [Geister, Cygnet, Cardiovision (CV) 195.10, CV 195.40, and CV 195.83] was assessed by clamping a 2.2-mm compression load cell with a dedicated computer universal serial bus interface at the proximal, the middle, and the distal site from the fulcrum. Biological response of the aortic wall was assessed in five minipigs (weight, 38Y40 kg) that underwent thoracic aorta clamping and leakage point test. Immunohistochemistry and morphometric analysis were carried out for each aortic segment tested. Results: Force generation pattern is peculiar of each clamp, being higher in the proximal and the middle portion and lower in the distal part. One clamp (Cygnet) exhibited homogeneous maximal force generation at all three sites. All clamps exhibited peculiar crushing artifacts. Avariable degree of endothelial layer disruption occurred in all clamping tests; three clamps (CV 195.10, Cygnet, and Geister) had the lower amount of intact endothelium. The clamping force was not associated with the degree of endothelial disruption (P value was not significant). Conclusions: The choice of a clamp that is not only minimally invasive in design but also least traumatic will help avoid complications of aortic manipulation
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