357 research outputs found

    Status of MICE

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    Muon ionization cooling is the only practical method for preparing high-brilliance beams needed for a neutrino factory or muon collider. The muon ionization cooling experiment (MICE) under development at the Rutherford Appleton Laboratory comprises a dedicated beamline to generate a range of input emittance and momentum, with time-of-flight and Cherenkov detectors to ensure a pure muon beam. A first measurement of emittance is performed in the upstream magnetic spectrometer with a scintillating-fiber tracker. A cooling cell will then follow, alternating energy loss in liquid hydrogen with RF acceleration. A second spectrometer identical to the first and a particle identification system will measure the outgoing emittance. Plans for measurements of emittance and cooling are described.Comment: Poster presented at ICHEP08 Conference, Philadelphia, USA, July 2008. 3 pages, 3 figure

    The MURAVES muon telescope: technology and expected performances

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    The MURAVES project aims to study the inner structure of the upper part of the Mt. Vesuvius volcano by muon radiography (muography) technique. Very high energy muons, produced by cosmic rays in the at- mosphere, can penetrate large thickness of rocks. By measuring the at- tenuation of the muons flux trough the volcano cone is possible to obtain a 2D image of the density structure. Internal discontinuities, with a spa- tial resolution of about 10 m, can be, in principle, resolved. An absolute average density measurement can be provided too. The project, funded by the Italian Ministry of University, Research and Education (MIUR), is led by INGV and INFN. In this article the mechanical structure of the de- tectors and background suppression techniques are reported

    Sustained proliferation in cancer: mechanisms and novel therapeutic targets

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    Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifested by alterations in cell metabolism. Once tumors appear, growth and metastasis may be supported by overproduction of appropriate hormones (in hormonally dependent cancers), by promoting angiogenesis, by undergoing epithelial to mesenchymal transition, by triggering autophagy, and by taking cues from surrounding stromal cells. A number of natural compounds (e.g., curcumin, resveratrol, indole-3-carbinol, brassinin, sulforaphane, epigallocatechin-3-gallate, genistein, ellagitannins, lycopene and quercetin) have been found to inhibit one or more pathways that contribute to proliferation (e.g., hypoxia inducible factor 1, nuclear factor kappa B, phosphoinositide 3 kinase/Akt, insulin-like growth factor receptor 1, Wnt, cell cycle associated proteins, as well as androgen and estrogen receptor signaling). These data, in combination with bioinformatics analyses, will be very important for identifying signaling pathways and molecular targets that may provide early diagnostic markers and/or critical targets for the development of new drugs or drug combinations that block tumor formation and progression

    Qualification study of SiPMs on a large scale for the CMVD Experiment

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    A Cosmic Muon Veto (CMV) detector using extruded plastic scintillators is being designed around the mini-Iron Calorimeter (mini-ICAL) detector at the transit campus of the India based Neutrino Observatory, Madurai for the feasibility study of shallow depth underground experiments. The scintillation signals that are produced in the plastic due to muon trajectories are absorbed by wavelength shifting (WLS) fibres. The WLS fibres re-emit photons of longer wavelengths and propagate those to silicon photo-multipliers (SiPMs). The SiPMs detect these photons, producing electronic signals. The CMV detector will use more than 700 scintillators to cover the mini-ICAL detector and will require around 3000 SiPMs. The design goal for the cosmic muon veto efficiency of the CMV is >99.99%. Hence, every SiPM used in the detector needs to be tested and characterised to satisfy the design goal of CMV. A mass testing system was developed for the measurement of gain and choice of the overvoltage (VovV_{ov}) of each SiPMs using an LED driver. The VovV_{ov} is obtained by studying the noise rate, the gain of the SiPM. This paper describes the experimental setup used to test the SiPMs characteristics along with detailed studies of those characteristics as a function of temperature.Comment: 16 pages, 20 figure

    Combined Forward-Backward Asymmetry Measurements in Top-Antitop Quark Production at the Tevatron

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    The CDF and D0 experiments at the Fermilab Tevatron have measured the asymmetry between yields of forward- and backward-produced top and antitop quarks based on their rapidity difference and the asymmetry between their decay leptons. These measurements use the full data sets collected in proton-antiproton collisions at a center-of-mass energy of s=1.96\sqrt s =1.96 TeV. We report the results of combinations of the inclusive asymmetries and their differential dependencies on relevant kinematic quantities. The combined inclusive asymmetry is AFBttˉ=0.128±0.025A_{\mathrm{FB}}^{t\bar{t}} = 0.128 \pm 0.025. The combined inclusive and differential asymmetries are consistent with recent standard model predictions
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