3 research outputs found
Neuronal differentiation of embryonic stem cells
- Author
- Publication venue
- Published by Elsevier B.V.
- Publication date
- 05/06/1996
- Field of study
AbstractNeuronal differentiation from totipotent precursors in vitro, is thought to require two signals: first a biophysical state (cellular aggregation) followed by a biochemical signal (retinoic acid treatment). In investigating the properties of retinoic acid-differentiated embryonic stem cell lines. However, we noted that retinoic acid treatment without prior aggregation, is sufficient to induce expression of the neuronal markers GAP-43 and NF-165. In agreement, immunohistochemistry revealed the presence of GAP-43 positive cells in these embryonic stem cell monolayers after three days of retinoic acid (RA) treatment. Furthermore an NF-165 positive subpopulation of cells was clearly observed after 4–5 days of RA treatment. The expression of these neuronal markers coincided with the appearance of electrically excitable cells, as assayed with whole cell patch clamp recording. We conclude that for neuronal differentiation of totipotent embryonic stem cells in vitro, one biochemical signal, i.e. retinoic acid treatment, is sufficient
No clinical utility of kras variant rs61764370 for ovarian or breast cancer
- Author
- Aben Katja K.
- Agnarsson Bjarni A.
- Aittomäki Kristiina
- Alducci Elisa
- Andrulis Irene L.
- Anton-Culver Hoda
- Antonenkova Natalia N.
- Antoniou Antonis C.
- Apicella Carmel
- Arndt Volker
- Arnold Norbert
- Arun Banu K.
- Arver Brita
- Ashworth Alan
- Baglietto Laura
- Balleine Rosemary
- Bandera Elisa V.
- Barrowdale Daniel
- Bean Yukie T.
- Beckmann Lars
- Beckmann Matthias W.
- Benitez Javier
- Berchuck Andrew
- Berger Andreas
- Berger Raanan
- Beuselinck Benoit
- Bisogna Maria
- Bjorge Line
- Blomqvist Carl
- Bogdanova Natalia V.
- Bojesen Anders
- Bojesen Stig E.
- Bolla Manjeet K.
- Bonanni Bernardo
- Brand Judith S.
- Brauch Hiltrud
- Brenner Hermann
- Brinton Louise
- Brooks-Wilson Angela
- Bruinsma Fiona
- Brunet Joan
- Brüning Thomas
- Budzilowska Agnieszka
- Bunker Clareann H.
- Burwinkel Barbara
- Butzow Ralf
- Buys Saundra S.
- Caligo Maria A.
- Campbell Ian
- Carter Jonathan
- Chang-Claude Jenny
- Chanock Stephen J.
- Chenevix-Trench Georgia
- Claes Kathleen B.M.
- Collée J. Margriet
- Cook Linda S.
- Couch Fergus J.
- Cox Angela
- Cramer Daniel
- Cross Simon S.
- Cunningham Julie M.
- Cybulski Cezary
- Czene Kamila
- Damiola Francesca
- Dansonka-Mieszkowska Agnieszka
- Darabi Hatef
- de la Hoya Miguel
- deFazio Anna
- Dennis Joseph
- Devilee Peter
- Dicks Ed M.
- Diez Orland
- Doherty Jennifer A.
- Domchek Susan M.
- Dorfling Cecilia M.
- du Bois Andreas
- Dumont Martine
- Dunning Alison M.
- Duran Mercedes
- Dörk Thilo
- Easton Douglas F.
- Eccles Diana
- Edwards Robert P.
- Ehrencrona Hans
- Ejlertsen Bent
- Ekici Arif B.
- Ellis Steve D.
- Engel Christoph
- Eriksson Mikael
- Fasching Peter A.
- Feliubadalo Lidia
- Figueroa Jonine
- Flesch-Janys Dieter
- Fletcher Olivia
- Fontaine Annette
- Fortuzzi Stefano
- Fostira Florentia
- Fridley Brooke L.
- Friebel Tara
- Friedman Eitan
- Friel Grace
- Frost Debra
- Garber Judy
- GarcÃa-Closas Montserrat
- Gayther Simon A.
- Gentry-Maharaj Aleksandra
- Gerdes Anne-Marie
- Giles Graham G.
- Glasspool Rosalind
- Glendon Gord
- Godwin Andrew K.
- Goode Ellen L.
- Goodman Marc T.
- Gore Martin
- Greene Mark H.
- Grip Mervi
- Gronwald Jacek
- Gschwantler Kaulich Daphne
- Guzman Starr R.
- Guénel Pascal
- Haeberle Lothar
- Haiman Christopher A.
- Hall Per
- Halverson Sandra L.
- Hamann Ute
- Hansen Thomas V.O.
- Harter Philipp
- Hartikainen Jaana M.
- Healey Sue
- Hein Alexander
- Heitz Florian
- Henderson Brian E.
- Herzog Josef
- Hogervorst Frans B.L.
- Hollestelle Antoinette
- Hooning Maartje J.
- Hopper John L.
- Humphreys Keith
- Huzarski Tomasz
- Høgdall Claus K.
- Høgdall Estrid
- Imyanitov Evgeny N.
- Isaacs Claudine
- Jakubowska Anna
- Janavicius Ramunas
- Jaworska Katarzyna
- Jensen Allan
- Jensen Uffe Birk
- Johnatty Sharon E.
- Johnson Nichola
- Jukkola-Vuorinen Arja
- Kabisch Maria
- Karlan Beth Y.
- Kataja Vesa
- Kauff Noah
- Kelemen Linda E.
- Kerin Michael J.
- Kiemeney Lambertus A.
- Kjaer Susanne K.
- Knight Julia A.
- Knol-Bout Jacoba P.
- Konstantopoulou Irene
- Kosma Veli-Matti
- Krakstad Camilla
- Kristensen Vessela
- Kuchenbaecker Karoline B.
- Kupryjanczyk Jolanta
- Laitman Yael
- Lambrechts Diether
- Lambrechts Sandrina
- Larson Melissa C.
- Lasa Adriana
- Laurent-Puig Pierre
- Lazaro Conxi
- Le Marchand Loic
- Le Nhu D.
- Leminen Arto
- Lester Jenny
- Levine Douglas A.
- Li Jingmei
- Liang Dong
- Lindblom Annika
- Lindor Noralane
- Lissowska Jolanta
- Long Jirong
- Lu Karen H.
- Lubinski Jan
- Lundvall Lene
- Lurie Galina
- Mai Phuong L.
- Mannermaa Arto
- Margolin Sara
- Mariette Frederique
- Marme Frederik
- Martens John W.M.
- Massuger Leon F.A.G.
- Maugard Christine
- Mazoyer Sylvie
- McGuffog Lesley
- McGuire Valerie
- McLean Catriona
- McNeish Iain
- Meindl Alfons
- Menegaux Florence
- Menkiszak Janusz
- Menon Usha
- Mensenkamp Arjen R.
- Menéndez Primitiva
- Miller Nicola
- Milne Roger L.
- Modugno Francesmary
- Montagna Marco
- Moysich Kirsten B.
- Mulligan Anna Marie
- Muranen Taru A.
- Müller Heiko
- Narod Steven A.
- Nathanson Katherine L.
- Ness Roberta B.
- Neuhausen Susan L.
- Nevanlinna Heli
- Neven Patrick
- Nielsen Finn C.
- Nielsen Sune F.
- Nordestgaard Børge G.
- Nussbaum Robert L.
- Odunsi Kunle
- Offit Kenneth
- Olah Edith
- Olopade Olufunmilayo I.
- Olson Janet E.
- Olson Sara H.
- Oosterwijk Jan C.
- Orlow Irene
- Orr Nick
- Orsulic Sandra
- Osorio Ana
- Ottini Laura
- Paul James
- Pearce Celeste L.
- Pedersen Inge Sokilde
- Peissel Bernard
- Pejovic Tanja
- Pelttari Liisa M.
- Perkins Jo
- Permuth-Wey Jenny
- Peterlongo Paolo
- Peto Julian
- Pharoah Paul D.P.
- Phelan Catherine M.
- Phillips Kelly-Anne
- Piedmonte Marion
- Pike Malcolm C.
- Pilar Zamora M.
- Platte Radka
- Plisiecka-Halasa Joanna
- Poole Elizabeth M.
- Poppe Bruce
- Pylkäs Katri
- Radice Paolo
- Ramus Susan J.
- Rebbeck Timothy R.
- Reed Malcolm W.R.
- Rennert Gad
- Risch Harvey A.
- Robson Mark
- Rodriguez Gustavo C.
- Romero Atocha
- Rookus Matti A.
- Rossing Mary Anne
- Rothstein Joseph H.
- Rudolph Anja
- Runnebaum Ingo
- Salani Ritu
- Salvesen Helga B.
- Sawyer Elinor J.
- Schildkraut Joellen M.
- Schmidt Marjanka K.
- Schmutzler Rita K.
- Schneeweiss Andreas
- Schoemaker Minouk J.
- Schrauder Michael G.
- Schumacher Fredrick
- Schwaab Ira
- Scuvera Giulietta
- Sellers Thomas A.
- Severi Gianluca
- Seynaeve Caroline M.
- Shah Mitul
- Shrubsole Martha
- Siddiqui Nadeem
- Sieh Weiva
- Silva Isabel Dos Santos
- Simard Jacques
- Singer Christian F.
- Sinilnikova Olga M.
- Smeets Dominiek
- Sohn Christof
- Soller Maria
- Song Honglin
- Soucy Penny
- Southey Melissa C.
- Stegmaier Christa
- Stoppa-Lyonnet Dominique
- Sucheston Lara
- Swerdlow Anthony
- T Hildebrandt Michelle A.
- Tangen Ingvild L.
- Tea Muy-Kheng
- Teixeira Manuel R.
- Terry Kathryn L.
- Terry Mary Beth
- Thomassen Mads
- Thompson Pamela J.
- Tihomirova Laima
- Tischkowitz Marc
- Toland Amanda Ewart
- Tollenaar Rob A.E.M.
- Tomlinson Ian
- Torres Diana
- Truong Thérèse
- Tsimiklis Helen
- Tung Nadine
- Tworoger Shelley S.
- Tyrer Jonathan P.
- Vachon Celine M.
- Van 't Veer Laura J.
- van Altena Anne M.
- Van Asperen C.J.
- van den Berg David
- van den Ouweland Ans M.W.
- van der Baan Frederieke H.
- van Doorn Helena C.
- Van Nieuwenhuysen Els
- van Rensburg Elizabeth J.
- Vergote Ignace
- Verhoef Senno
- Vierkant Robert A.
- Vijai Joseph
- Vitonis Allison F.
- von Wachenfeldt Anna
- Walsh Christine
- Wang Qin
- Wang-Gohrke Shan
- Wappenschmidt Barbara
- Weischer Maren
- Weitzel Jeffrey N.
- Weltens Caroline
- Wentzensen Nicolas
- Whittemore Alice S.
- Wilkens Lynne R.
- Winqvist Robert
- Wu Anna H.
- Wu Xifeng
- Yang Hannah P.
- Zaffaroni Daniela
- Zheng Wei
- Ziogas Argyrios
- Publication venue
- Elsevier BV
- Publication date
- 01/05/2016
- Field of study
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science. © The Author(s) 2019. Published by Oxford University Press