2 research outputs found
ΠΠΠΠ£ΠΠΠΠΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠ ΠΠ‘ΠΠΠΠ’Π« Π ΠΠΠΠΠΠ Π ΠΠΠΠΠ’ΠΠΠΠΠΠΠ ΠΠ Π’Π ΠΠ’Π
The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.Β ΠΠ·ΡΡΠ΅Π½ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°Π»Π»Π΅Π»Π΅ΠΉ Π³Π΅Π½Π° HLA-DRB1 Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°Π½Π½ΠΈΠΌ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΡΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ ΠΈ ΠΎΡΠ΅Π½Π΅Π½Π° ΠΈΡ
Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°ΡΡΡΠΈΡΠ°. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΠΈΠ»Π° Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ Π°Π»Π»Π΅Π»Π΅ΠΉ Π³Π΅Π½Π° HLA-DRB1 Ρ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ΅ΠΉ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΈΡΡΡΠ»Π»ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠ΅ΠΏΡΠΈΠ΄Π°ΠΌ ΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠΌΡ ΡΠ°ΠΊΡΠΎΡΡ ΠΊΠ»Π°ΡΡΠ° Π. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΡΡΠΎΠΊΠΎ- ΠΈ Π½ΠΈΠ·ΠΊΠΎΡΠ°Π·ΡΠ΅ΡΠ°ΡΡΠ΅Π³ΠΎ Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°Π»Π»Π΅Π»Π΅ΠΉ HLA-DRB1. Π£ Π±ΠΎΠ»ΡΠ½ΡΡ
ΡΠ°Π½Π½ΠΈΠΌ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΡΠΌ Π°ΡΡΡΠΈΡΠΎΠΌ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π°Π»Π»Π΅Π»ΠΈ Π³Π΅Π½Π° HLA-DRB1, ΡΠ²Π»ΡΡΡΠΈΠ΅ΡΡ ΠΌΠ°ΡΠΊΠ΅ΡΠ°ΠΌΠΈ ΡΠΈΡΠΊΠ° ΠΈ ΠΏΡΠΎΡΠ΅ΠΊΡΠΈΠΈ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°ΡΡΡΠΈΡΠ°, Π΄Π΅ΡΠ΅ΡΠΌΠΈΠ½ΠΈΡΡΡΡΠΈΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ Π°Π½ΡΠΈΡΠ΅Π» ΠΊ ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠΈΡΡΡΠ»Π»ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠ΅ΠΏΡΠΈΠ΄Π°ΠΌ, Π½ΠΎ Π½Π΅ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Ρ Π°Π½ΡΠΈΡΠ΅Π»Π°ΠΌΠΈ ΠΊΠ»Π°ΡΡΠ° M ΠΊ ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠΌΡ ΡΠ°ΠΊΡΠΎΡΡ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠΎΠ³ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΎ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΡΠ΅Π²ΠΌΠ°ΡΠΎΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°ΡΡΡΠΈΡΠ°.Β