Chronic cardiac denervation affects the speed of coronary vascular regulation

OBJECTIVE: We tested the hypothesis that the rate of adaptation of coronary metabolic vasodilatation and autoregulation is modulated by the cardiac nerves. METHODS: Anaesthetised dogs (seven innervated (control) and seven with denervated hearts) were subjected to controlled pressure perfusion of the left main coronary artery. Heart rate was controlled by pacing. RESULTS: The steady state autoregulation curves and metabolic regulation curves were similar in the two groups. A sudden increase or decrease in heart rate was associated with a faster response (22% shorter half-times) in the innervated than the denervated dogs (P < 0.001). A sudden increase or decrease in coronary arterial perfusion pressure was associated with a slower response (24% longer half-times) in the innervated than the denervated hearts (P < 0.005). CONCLUSIONS: We conclude that the speed of response to metabolic and perfusion pressure changes is partly mediated by cardio-cardiac reflexes. Reflex coronary vasodilatation appears to reinforce the metabolic vasodilatation of a heart rate increase and oppose the vasoconstriction in response to increased perfusion pressur

Correction to: Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet

Following publication of the original article [1], the authors regret errors in Fig. 3b–d. In these figures, the images of the representative Akt and phospho-Akt (pAkt) signals should be replaced with the appropriate images. The representative images shown here are correct. The changes do not affect the scientific conclusion and significance of the article. (Figure presented.)