12,160 research outputs found
Sliding mode control of quantum systems
This paper proposes a new robust control method for quantum systems with
uncertainties involving sliding mode control (SMC). Sliding mode control is a
widely used approach in classical control theory and industrial applications.
We show that SMC is also a useful method for robust control of quantum systems.
In this paper, we define two specific classes of sliding modes (i.e.,
eigenstates and state subspaces) and propose two novel methods combining
unitary control and periodic projective measurements for the design of quantum
sliding mode control systems. Two examples including a two-level system and a
three-level system are presented to demonstrate the proposed SMC method. One of
main features of the proposed method is that the designed control laws can
guarantee desired control performance in the presence of uncertainties in the
system Hamiltonian. This sliding mode control approach provides a useful
control theoretic tool for robust quantum information processing with
uncertainties.Comment: 18 pages, 4 figure
Convolutional LSTM Networks for Subcellular Localization of Proteins
Machine learning is widely used to analyze biological sequence data.
Non-sequential models such as SVMs or feed-forward neural networks are often
used although they have no natural way of handling sequences of varying length.
Recurrent neural networks such as the long short term memory (LSTM) model on
the other hand are designed to handle sequences. In this study we demonstrate
that LSTM networks predict the subcellular location of proteins given only the
protein sequence with high accuracy (0.902) outperforming current state of the
art algorithms. We further improve the performance by introducing convolutional
filters and experiment with an attention mechanism which lets the LSTM focus on
specific parts of the protein. Lastly we introduce new visualizations of both
the convolutional filters and the attention mechanisms and show how they can be
used to extract biological relevant knowledge from the LSTM networks
2015 Update on Acute Adverse Reactions to Gadolinium based Contrast Agents in Cardiovascular MR. Large Multi-National and Multi-Ethnical Population Experience With 37788 Patients From the EuroCMR Registry
Objectives: Specifically we aim to demonstrate that the results of our earlier safety data hold true in this much larger multi-national and multi-ethnical population. Background: We sought to re-evaluate the frequency, manifestations, and severity of acute adverse reactions associated with administration of several gadolinium- based contrast agents during routine CMR on a European level. Methods: Multi-centre, multi-national, and multi-ethnical registry with consecutive enrolment of patients in 57 European centres. Results: During the current observation 37788 doses of Gadolinium based contrast agent were administered to 37788 patients. The mean dose was 24.7 ml (range 5–80 ml), which is equivalent to 0.123 mmol/kg (range 0.01 - 0.3 mmol/kg). Forty-five acute adverse reactions due to contrast administration occurred (0.12 %). Most reactions were classified as mild (43 of 45) according to the American College of Radiology definition. The most frequent complaints following contrast administration were rashes and hives (15 of 45), followed by nausea (10 of 45) and flushes (10 of 45). The event rate ranged from 0.05 % (linear non-ionic agent gadodiamide) to 0.42 % (linear ionic agent gadobenate dimeglumine). Interestingly, we also found different event rates between the three main indications for CMR ranging from 0.05 % (risk stratification in suspected CAD) to 0.22 % (viability in known CAD). Conclusions: The current data indicate that the results of the earlier safety data hold true in this much larger multi-national and multi-ethnical population. Thus, the “off-label” use of Gadolinium based contrast in cardiovascular MR should be regarded as safe concerning the frequency, manifestation and severity of acute events
Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects.
BACKGROUND: The consequences of exercise-induced premature ventricular contractions (PVCs) in asymptomatic individuals remain unclear. This study aimed to assess the association between PVC burdens during submaximal exercise and major adverse cardiovascular events (MI/HF/LTVA: myocardial infarction [MI], heart failure [HF], and life-threatening ventricular arrhythmia [LTVA]), and all-cause mortality. Additional end points were MI, LTVA, HF, and cardiovascular mortality. METHODS: A neural network was developed to count PVCs from ECGs recorded during exercise (6 minutes) and recovery (1 minute) in 48 315 asymptomatic participants from UK Biobank. Associations were estimated using multivariable Cox proportional hazard models. Explorative studies were conducted in subgroups with cardiovascular magnetic resonance imaging data (n=6290) and NT-proBNP (N-terminal Pro-B-type natriuretic peptide) levels (n=4607) to examine whether PVC burden was associated with subclinical cardiomyopathy. RESULTS: Mean age was 56.8±8.2 years; 51.1% of the participants were female; and median follow-up was 12.6 years. Low PVC counts during exercise and recovery were both associated with MI/HF/LTVA risk, independently of clinical factors: adjusted hazard ratio (HR), 1.2 (1-5 exercise PVCs, P20 exercise PVCs, P5 recovery PVCs, P20 exercise PVCs, P5 recovery PVCs, P<0.001). Complex PVC rhythms were associated with higher risk compared with PVC count alone. PVCs were also associated with incident HF, LTVA, and cardiovascular mortality, but not MI. In the explorative studies, high PVC burden was associated with larger left ventricular volumes, lower ejection fraction, and higher levels of NT-proBNP compared with participants without PVCs. CONCLUSION: In this cohort of middle-aged and older adults, PVC count during submaximal exercise and recovery were both associated with MI/HF/LTVA, all-cause mortality, HF, LTVAs, and cardiovascular mortality, independent of clinical and exercise test factors, indicating an incremental increase in risk as PVC count rises. Complex PVC rhythms were associated with higher risk compared with PVC count alone. Underlying mechanisms may include the presence of subclinical cardiomyopathy
An approximate 3D computational method for real-time computation of induction logging responses
Runaway Events Dominate the Heavy Tail of Citation Distributions
Statistical distributions with heavy tails are ubiquitous in natural and
social phenomena. Since the entries in heavy tail have disproportional
significance, the knowledge of its exact shape is very important. Citations of
scientific papers form one of the best-known heavy tail distributions. Even in
this case there is a considerable debate whether citation distribution follows
the log-normal or power-law fit. The goal of our study is to solve this debate
by measuring citation distribution for a very large and homogeneous data. We
measured citation distribution for 418,438 Physics papers published in
1980-1989 and cited by 2008. While the log-normal fit deviates too strong from
the data, the discrete power-law function with the exponent does
better and fits 99.955% of the data. However, the extreme tail of the
distribution deviates upward even from the power-law fit and exhibits a
dramatic "runaway" behavior. The onset of the runaway regime is revealed
macroscopically as the paper garners 1000-1500 citations, however the
microscopic measurements of autocorrelation in citation rates are able to
predict this behavior in advance.Comment: 6 pages, 5 Figure
Classical Cepheid Pulsation Models. III. The Predictable Scenario
Within the current uncertainties in the treatment of the coupling between
pulsation and convection, limiting amplitude, nonlinear, convective models
appear the only viable approach for providing theoretical predictions about the
intrinsic properties of radial pulsators. In this paper we present the results
of a comprehensive set of Cepheid models computed within such theoretical
framework for selected assumptions on their original chemical composition.Comment: 24 pages, 1 latex file containing 6 tables, 10 postscript figures,
accepted for publication on Ap
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