Parallel Natural Language Parsing: From Analysis to Speedup

Electrical Engineering, Mathematics and Computer Scienc

Bureaus, Clients, and Congress: The Impact of Interest Group Support on Budgeting

Richard Fenno, in Power of the Purse, contends that the budget process responds to interest group pressures. This study examines that hypothesis for 20 bureaus in the Department of Agriculture for the fiscal years 1971-1976. Cultivating clientele support both among interest groups and members of Congress appears to aid a bureau's budget position. Bureaus with strong support not only avoid budget cuts but grow rapidly from year to year.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Introduction

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68468/2/10.1177_107554708600800101.pd

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light. To determine whether colorectal cancer cells respond to EZH2 inhibition and to explore which factors influence the degree of response, we treated a panel of 20 organoid lines derived from human colon tumors with different concentrations of the EZH2 inhibitor GSK126. The resulting responses were associated with mutation status, gene expression and responses to other drugs. We found that the response to GSK126 treatment greatly varied between organoid lines. Response associated with the mutation status of ATRX and PAX2, and correlated with BIK expression. It also correlated well with response to Nutlin-3a which inhibits MDM2-p53 interaction thereby activating p53 signaling. Sensitivity to EZH2 ablation depended on the presence of wild type p53, as tumor organoids became resistant when p53 was mutated or knocked down. Our exploratory study provides insight into which genetic factors predict sensitivity to EZH2 inhibition. In addition, we show that the response to EZH2 inhibition requires wild type p53. We conclude that a subset of colorectal cancer patients may benefit from EZH2-targeting therapies

Stem Cells and Cancer The Polycomb Connection

AbstractProteins from the Polycomb group (PcG) are epigenetic chromatin modifiers involved in cancer development and also in the maintenance of embryonic and adult stem cells. The therapeutic potential of stem cells and the growing conviction that tumors contain stem cells highlights the importance of understanding the extrinsic and intrinsic circuitry controlling stem cell fate and their connections to cancer