VOEvent Standard for Fast Radio Bursts

Fast radio bursts are a new class of transient radio phenomena currently detected as millisecond radio pulses with very high dispersion measures. As new radio surveys begin searching for FRBs a large population is expected to be detected in real-time, triggering a range of multi-wavelength and multi-messenger telescopes to search for repeating bursts and/or associated emission. Here we propose a method for disseminating FRB triggers using Virtual Observatory Events (VOEvents). This format was developed and is used successfully for transient alerts across the electromagnetic spectrum and for multi-messenger signals such as gravitational waves. In this paper we outline a proposed VOEvent standard for FRBs that includes the essential parameters of the event and where these parameters should be specified within the structure of the event. An additional advantage to the use of VOEvents for FRBs is that the events can automatically be ingested into the FRB Catalogue (FRBCAT) enabling real-time updates for public use. We welcome feedback from the community on the proposed standard outlined below and encourage those interested to join the nascent working group forming around this topic.Comment: 11 pages, 2 figures, parameter definition table in appendi

Standard Operating Procedure - Collaborative Spatial Assessment CoSA - Release 1.0

The purpose of this Standard Operating Procedure (SOP) is to establish uniform procedures pertaining to the preparation for, the performance of, and the reporting of COllaborative (geo) Spatial Assessment (CoSA). CoSA provides a synoptic, unbiased assessment over the impact area of a disaster, which feeds the two main recovery perspectives of the Post-Disaster Needs Assessment (PDNA): i) the valuation of damages and losses carried out through the Damage and Loss Assessment (DaLA) methodology; and ii) the identification of human impacts and recovery needs carried out though the Human Recovery Needs Assessment (HRNA). CoSA is distinct from other geospatial and remote sensing based assessments because it i) draws on the collaborative efforts of distributed capacities in remote sensing and geospatial analysis, ii) aims to achieve the highest possible accuracy in line with the requirements of the PDNA and iii) tries to do so under stringent timing constraints set by the PDNA schedule. The current SOP will aid in ensuring credibility, consistency, transparency, accuracy and completeness of the CoSA. It is a living document, however, that will be enriched with new practical experiences and regularly updated to incorporate state-of-the-art procedures and new technical developments.JRC.DG.G.2-Global security and crisis managemen

Состояние сексуального здоровья супругов после хирургического вмешательства на внутренних гениталиях женщин

Установлены влияние разных видов операции на сексуальную функцию женщин, причины развития и клинические формы дезадаптации супружеской пары. Сделано заключение о необходимости учитывать при психотерапевтической коррекции дезадаптации помимо объема операции психологические и социально-психологические факторы, способствующие формированию дезадаптации супругов, а в ряде случаев являющиеся ее причиной.The influence of various types of surgery on sexual function of women as well as the causes of development and clinical forms of spouse deadaptation were established. The author concludes about the necessity to consider mental and social-psychological factors contributing formation of spouse deadaptation and its cause in a number of cases in addition to the volume of the surgery at psychotherapeutic correction of deadaptation

Asteroseismology of the Transiting Exoplanet Host HD 17156 with HST FGS

Observations conducted with the Fine Guidance Sensor on Hubble Space Telescope (HST) providing high cadence and precision time-series photometry were obtained over 10 consecutive days in December 2008 on the host star of the transiting exoplanet HD 17156b. During this time 10^12 photons (corrected for detector deadtime) were collected in which a noise level of 163 parts per million per 30 second sum resulted, thus providing excellent sensitivity to detection of the analog of the solar 5-minute p-mode oscillations. For HD 17156 robust detection of p-modes supports determination of the stellar mean density of 0.5301 +/- 0.0044 g/cm^3 from a detailed fit to the observed frequencies of modes of degree l = 0, 1, and 2. This is the first star for which direct determination of the mean stellar density has been possible using both asteroseismology and detailed analysis of a transiting planet light curve. Using the density constraint from asteroseismology, and stellar evolution modeling results in M_star = 1.285 +/- 0.026 solar, R_star = 1.507 +/- 0.012 solar, and a stellar age of 3.2 +/- 0.3 Gyr.Comment: Accepted by ApJ; 16 pages, 18 figure

A Radio Pulsar/X-ray Binary Link

Radio pulsars with millisecond spin periods are thought to have been spun up by transfer of matter and angular momentum from a low-mass companion star during an X-ray-emitting phase. The spin periods of the neutron stars in several such low-mass X-ray binary (LMXB) systems have been shown to be in the millisecond regime, but no radio pulsations have been detected. Here we report on detection and follow-up observations of a nearby radio millisecond pulsar (MSP) in a circular binary orbit with an optically identified companion star. Optical observations indicate that an accretion disk was present in this system within the last decade. Our optical data show no evidence that one exists today, suggesting that the radio MSP has turned on after a recent LMXB phase.Comment: published in Scienc

Risk of endometrial cancer after tamoxifen treatment of breast cancer

Since large trials have been set up to assess whether tamoxifen decreases the risk of breast cancer in healthy women, it has become important to investigate the drug's potential adverse effects, including occurrence of endometrial cancer. We undertook a case-cont

EMC testing of electricity meters using real-world and artificial current waveforms

In 2015, the energy measurement of some static electricity meters was found to be sensitive to specific conducted electromagnetic disturbances with very fast current changes caused by highly nonlinear loads, leading to meter errors up to several hundred percent. This article describes new results on the electromagnetic compatibility (EMC) of 16 different meters from all over Europe when exposed to real-world disturbance signals. Those test signals were obtained from household appliances and onsite measurements at metered supply points all over Europe. The results show that also the interference signals recorded onsite can cause measurement errors as large as several hundred percent, even for meters that pass the present EMC standards. This unambiguously demonstrates that the present immunity testing standards do not cover the most disturbing conducted interference occurring in present daily-life situations due to the increased use of nonlinear electronics. Furthermore, to enable the adoption of potential new test waveforms in future standards for electricity meter testing, artificial test waveforms were constructed based on real-world waveforms using a piece-wise linear model. These artificial test waveforms were demonstrated to cause meter errors similar to those caused by the original real-life waveforms they are representing, showing that they are suitable candidates for use in improved standardization of electricity meter testing.Postprint (published version

Cardiovascular Disease in Testicular Cancer Survivors:Identification of Risk Factors and Impact on Quality of Life

PURPOSE: Testicular cancer (TC) treatment is clearly associated with cardiovascular morbidity and mortality. To enable development of preventive strategies for cardiovascular disease (CVD), we assessed cardiometabolic risk factors and quality of life (QoL) in TC survivors.METHODS: Incidence of coronary artery disease, myocardial infarction, and heart failure after TC treatment was assessed in a multicenter cohort comprising 4,748 patients treated at the age of 12-50 years between 1976 and 2007. Patients who had developed CVD and a random sample from the cohort (subcohort) received a questionnaire on cardiometabolic risk factors and QoL. A subgroup of responders in the subcohort additionally underwent clinical evaluation of cardiovascular risk factors.RESULTS: After a median follow-up of 16 years, 272 patients had developed CVD. Compared with orchidectomy only, cisplatin combination chemotherapy was associated with an increased CVD risk (hazard ratio [HR], 1.9; 95% CI, 1.1 to 3.1). Patients who were obese or a smoker at diagnosis (HR, 4.6; 95% CI, 2.0 to 10.0 and HR, 1.7; 95% CI, 1.1 to 2.4, respectively), developed Raynaud's phenomenon (HR, 1.9; 95% CI, 1.1 to 3.6) or dyslipidemia (HR, 2.8; 95% CI, 1.6 to 4.7) or had a positive family history for CVD (HR, 2.9; 95% CI, 1.7 to 4.9) had higher CVD risk. More TC survivors with CVD reported inferior QoL on physical domains than survivors who did not develop CVD. Of 304 TC survivors who underwent clinical evaluation for cardiovascular risk factors (median age at assessment: 51 years), 86% had dyslipidemia, 50% had hypertension, and 35% had metabolic syndrome, irrespective of treatment.CONCLUSION: Cardiovascular events in TC survivors impair QoL. Many TC survivors have undetected cardiovascular risk factors. We advocate early lifestyle adjustments and lifelong follow-up with low-threshold treatment of cardiovascular risk factors, especially in obese and smoking patients treated with platinum-based chemotherapy.</p

Influence of enzalutamide on cabazitaxel pharmacokinetics: A Drug–Drug interaction study in metastatic castration-resistant prostate cancer (mCRPC) patients

Purpose: In ongoing clinical research on metastatic castration-resistant prostate cancer (mCRPC) treatment, the potential enhanced efficacy of the combination of taxanes with AR-targeted agents, that is, enzalutamide and abiraterone, is currently being explored. Because enzalutamide induces the CYP3A4 enzyme and taxanes are metabolized by this enzyme, a potential drug–drug interaction needs to be investigated. Experimental Design: Therefore, we performed a pharmacokinetic cross-over study in mCRPC patients who were scheduled for treatment with cabazitaxel Q3W (25 mg/m2). Patients were studied for three consecutive cabazitaxel cycles. Enzalutamide (160 mg once daily) was administered concomitantly after the first cabazitaxel cycle, during 6 weeks. Primary endpoint was the difference in mean area under the curve (AUC) between the first (cabazitaxel monotherapy) and third cabazitaxel cycle, when enzalutamide was added. Results: A potential clinically relevant 22% (95% CI, 9%–34%; P ¼ 0.005) reduction in cabazitaxel exposure was found with concomitant enzalutamide use. The geometric mean AUC0–24h of cabazitaxel was 181 ngh/mL (95% CI, 150–219 ngh/mL) in cycle 3 and 234 ngh/mL (95% CI, 209–261 ngh/mL) in cycle 1. This combination did not result in excessive toxicity, whereas PSA response was promising. Conclusions: We found a significant decrease in cabazitaxel exposure when combined with enzalutamide. In an era of clinical trials on combination strategies for mCRPC, it is important to be aware of clinically relevant drug–drug interactions. Because recent study results support the use of a lower standard cabazitaxel dose of 20 mg/m2, the clinical relevance of this interaction may be substantial, because the addition of enzalutamide may result in subtherapeutic cabazitaxel exposure