WIRED: World Wide Web Interactive Remote Event Display

WIRED is a framework, written in Java, to build High Energy Physics event displays that can be used across the network. To guarantee portability across all platforms, WIRED is implemented in the Java language and uses the Swing user interface component set. It can be used as a stand-alone application or as an applet inside a WWW browser. The graphical user interface allows for multiple views and for multiple controls acting on those views. A detector tree control is available to toggle the visibility of parts of the events and detector geometry. XML (Extensible Markup Language), RMI (Remote Method Invocation) and CORBA loaders can be used to load event data as well as geometry data, and to connect to FORTRAN, C, C++ and Java reconstruction programs. Non-linear and non-Cartesian projections (e.g. fish-eye, rho-phi, rho-Z, phi-Z) provide special views to get a better understanding of events. WIRED has grown to be a framework in use and under development in several HEP experiments (ATLAS, CHORUS, DELPHI, LHCb, BaBar, D0 and ZEUS). WIRED event displays have also proven to be useful to explain High Energy Physics to the general public. Both CERN, in its travelling exhibition and MicroCosm, and RAL, during its open days, have displays set up

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points