Specification Techniques for Multi-Modal Dialogues in the U-Wish Project

In this paper we describe the development of a specification\ud technique for specifying interactive web-based services. We\ud wanted to design a language that can be a means of\ud communication between designers and developers of interactive services, that makes it easier to develop web-based services fitted to the users and that shortens the pathway from design to implementation. The language, still under development, is based on process algebra and can be\ud connected to the results of task analysis. We have been\ud working on the automatic generation of executable prototypes\ud out of the specifications. In this way the specification\ud language can establish a connection between users, design\ud and implementation. A first version of this language is\ud available as well as prototype tools for executing the specifications. Ideas will be given as to how to make the connection between specifications and task analysis

Buyer focus: evaluation of a new concept for supply chain integration

The goal of integrated supply chains is to remove barriers to ease the flow of materials and information. This article concentrates on an important barrier: shared resources in a supply chain. The removal of these shared resources is closely related to the recently introduced concept of buyer focus. Buyer focus is described as the singling out of resources in order to supply one buyer along the whole range of its products. The value of buyer focus for supply chain integration is evaluated and in two cases illustrated. This article suggests that there are two extreme configurations in supply chains. On the one hand, suppliers with buyer-focused operations to enable high levels of integration in order to cope with uncertainty in volume, mix and leadtime. On the other hand, shared resources and low levels of integration, which are more likely in supply chains that are dominantly cost driven.

Redesigning the supply of gasses:co-makership in a hospital

Supply chain management in hospitals has been relatively ignored. Due to tight budget constraints attention has been turned to the supply of materials as a possibility to cut costs. This paper describes the operational logistical relation between a hospital an its supplier of gasses and suggests alternatives for a closer, co-makership-like relation. To describe and analyse this relation a supply chain concept is elaborated upon that consists of four areas of attention: physical supply, control and co-ordination, organisation and relation, and information systems. Three scenarios are developed for an alternative design of the supply chain. The approach yields a considerable grow in insight for the two organisations into the logistical operation. We think that the approach is also valuable for the analysis and redesign of the logistical aspects in the supply of goods in other organisations.

Modelling of silicon condenser microphones

Several models concerning the sensitivity of capacitive pressure sensors have been presented in the past. Modelling of condenser microphones, which can be considered to be a special type of capacitive pressure sensor, usually requires a more complicated analysis of the sensitivity, because they have a strong electric field in the air gap. It is found that the mechanical sensitivity of condenser microphones with a circular diaphragm, either with a large initial tension or without any initial tension, increases with increasing bias voltage (and the corresponding static deflection), whereas the mechanical sensitivity of other capacitive pressure sensors does not depend on the static deflection. It is also found that the mechanical sensitivity increases with increasing input capacitance of a preamplifier. In addition, the open-circuit electrical sensitivity and, consequently, the total sensitivity too, also increases with increasing bias voltage (or static deflection). However, the maximum allowable sound pressure at which the diaphragm collapses, an effect that has to be taken into account, decreases with increasing static deflection in most cases, ulthnately resulting in an optimum value for the bias voltage. The model for microphones with a circular highly tensioned diaphragm has been verified successfully for two microphone types

Visualizing immune checkpoints and T cells in patients with cancer

This thesis describes the results of clinical studies using molecular imaging to visualize immune checkpoint molecules and immune cells in patients with solid tumors. These imaging results are used to improve our understanding of the anti-tumor immune response follow immune checkpoint inhibitor therapy and to assess whether these results can predict tumor response to therapy

Combined make-to-order and make-to-stock in a food production system

The research into multi-product production/inventory control systems has mainly assumed one of the two strategies: Make-to-Order (MTO) or Make-to-Stock (MTS). In practice, however, many companies cater to an increasing variety of products with varying logistical demands (e.g. short due dates, specific products) and production characteristics (e.g. capacity usage, setup) to different market segments and so they are moving to more MTO-production. As a consequence they operate under a hybrid MTO-MTS strategy. Important issues arising out of such situations are, for example, which products should be manufactured to stock and which ones on order and, how to allocate capacity among various MTO-MTS products. This paper presents the state-of-the-art literature review of the combined MTO-MTS production situations. A variety of production management issues in the context of food processing companies, where combined MTO-MTS production is quite common, are discussed in details. The authors propose a comprehensive hierarchical planning framework that covers the important production management decisions to serve as a starting point for evaluation and further research on the planning system for MTO-MTS situations.