Autobiographical memory specificity and symptoms of complicated grief, depression, and posttraumatic stress disorder following loss

This study examined the specificity and content of autobiographical memories among bereaved individuals. Self-report measures of bereavement-related distress and a standard and trait version of the Autobiographical Memory Test (AMT) were administered to 109 bereaved people. We examined associations of memory specificity with (a) demographic and loss-related variables and with (b) symptom-levels of complicated grief (CG), depression, and posttraumatic stress disorder (PTSD), (c) associations of the content of memories (related vs. unrelated to the loss/lost person) with symptoms, and (d) the degree to which associations of symptom-levels with memory specificity and content differed between the standard and trait version of the AMT. Findings showed that (a) memory specificity varied as a function of age, education, and kinship; (b) reduced memory specificity was significantly associated with symptom-levels of CG, but not depression and PTSD; (c) symptom-levels of CG and PTSD were associated with a preferential retrieval of specific memories that were related to the loss/lost person on the standard AMT, whereas all three symptom-measures were associated with preferential retrieval of loss-related specific memories on the trait AMT; and (d) on the trait AMT, but not the standard AMT, symptom-measures remained significantly associated with a preferential retrieval of loss-related specific memories, when controlling for relevant background variables. Among other things, these results show that reduced memory specificity is associated with self-reported CG-severity but not depression and PTSD following loss. Moreover, the results are consistent with recent research findings showing that memories tied to the source of an individual's distress (e.g., loss) are immune to avoidant processes involved in the standard reduced specificity effect. (C) 2010 Elsevier Ltd. All rights reserved

The effect of N-acetylcysteine and working memory training on cocaine use, craving and inhibition in regular cocaine users: correspondence of lab assessments and Ecological Momentary Assessment

Effective treatment for cocaine use disorder should dampen hypersensitive cue-induced motivational processes and/or strengthen executive control. Using a randomized, double-blind, placebo-controlled intervention, the primary aim of this study was to investigate the effect of N-Acetylcysteine (NAC) and working memory (WM)-training to reduce cocaine use and craving and to improve inhibition assessed in the laboratory and during Ecological Momentary Assessment (EMA). The second aim was to examine correspondence between laboratory and EMA data. Twenty-four of 38 cocaine-using men completed a 25-day intervention with 2400mg/day NAC or placebo and WM-training as well as two lab-visits assessing cocaine use, craving and inhibition (Stop Signal task). Additionally, cocaine use, craving and cognition (Stroop task) were assessed using EMA during treatment, with 26 participants completing 819 assessments. Cocaine problems according to the Drug Use Disorder Identification Test (DUDIT) decreased more after NAC than after placebo, and the proportion of cocaine-positive urines at lab-visit 2 was lower in the NAC group. No NAC effects were found on craving. For cocaine use and craving, results from the lab data were generally similar to EMA results. NAC also showed some effects on cognitive control: improved inhibition assessed with the Stop Signal task in the lab, and decreased classic Stroop performance during EMA. There were no significant effects of number of completed WM-training sessions. Overall this study revealed mixed findings regarding the treatment of cocaine use disorders with NAC and WM-training. The effect of NAC on inhibition should be further investigate