ASSESSMENT OF THE INFLUENCE OF SYSTEMIC ENZYME THERAPY ON CYTOKINE REGULATION OF ANIMAL ADAPTATION PROCESSES TO INTENSIVE PHYSICAL EXERCISE

Abstract. An experimental group of 45 nondescript white mice was selected for a study of the influence of systemic enzyme therapy on performance and ability to withstand intensive physical loads, as well as on production of main cytokines. The findings were compared to a control group of 45 mice who received placebo. The physical performance was assessed after 1, 2, and 3 weeks according to the length of test swimming in the aquarium with the attached load of 5% of the body mass. Findings indicate that systemic enzyme therapy led to increased performance and endurance with increased physical load in the experimental group after three weeks of therapy. The mice in the experimental group showed decreased levels of anti-inflammatory TNFα and IL - 1β. Other observed changes were within the error range. (Med. Immunol., vol. 10, N 6, pp 577-582)