L-GLUTAMINE ERADICATES HELICOBACTER PYLORI GASTRITIS: A NOVEL CASE REPORT

  Helicobacter pylori is the most common infection causing gastrointestinal diseases in the developing countries. It causes oxidative damage to gastric mucosal cells thereby altering the epithelial proliferation of these cells. With proton pump inhibitors and antibiotics being the mainstay in the management of symptoms, preclinical and clinical research is making inroads with novel therapeutic innovations to target the bacterium with the help of antioxidants. Hence, we report the first case of the treatment and eradication of H. pylori using L-glutamine, a sports medicine supplement with high antioxidant potential

TACROLIMUS INDUCED TREMORS AMONG POST RENAL TRANSPLANT PATIENTS: A CASE SERIES

Triple immunosuppression in renal transplant has drastically changed the outcome of graft survival. However, concern always remains among thephysicians because of adverse effects produced due to triple immunosuppression. Calcineurin inhibitors are associated with wide range of side effects. Hence, we report a case series of tremors associated with tacrolimus among renal transplant patients in a tertiary care hospital in southern India.Â

VALGANCICLOVIR INDUCED THROMBOCYTOPENIA: A CASE REPORT

Triple immunosuppression is very pivotal in maintaining the graft in case of renal transplantation. But because of severe immunosuppression, always there is chance of severe adverse effects. Hematological toxicity is usually very common but dreaded in case of renal transplant patients. Here, we report a case of valganciclovir-induced drop in platelet counts in a postrenal transplant patient

L-ASPARAGINASE INDUCED HYPOFIBRINOGENEMIA: A CASE REPORT

Anticancer therapy is always known to cause various side effects. L-asparaginase used in the treatment of adult T-cell lymphoblastic leukemia is anovel class of drug, an enzyme produced from plants as well as microorganisms except human. It is known to cause various adverse reactions including life-threatening neurological complications and thrombotic disorders. Hence, we report a case of hypofibrinogenemia associated with L-asparaginase in a patient treated for T-cell adult lymphoblastic leukemia.Â

MANAGEMENT OF DEPRESSION IN TERMINALLY ILL PATIENTS – A CRITICAL REVIEW

Depression is a well-recognized risk factor for shortened life span from cancer. Depression is among the main causes of disability in the world leadingto increased suffering and mortality. As per research surveys over the years, prevalence among cancer patients varies widely from 3% to 38% formajor depression and 1.5-52% for depression spectrum syndromes. The need of the hour is to effectively treat depression in cancer patients so thatthe quality of life can be improved and thereby patient survival. Both psychological and pharmacological interventions and the combination of bothvery much effective in treating depression in cancer patients. A broad range of therapies now exist, and the art of such therapy is the strategic selectionof components from several models to best respond to the needs of the individual patient and his/her family in the specific circumstances, whetherclinical, psychological, spiritual, or social.Â

A COMPLETE REVIEW OF MIGRAINE

Migraine characterized by recurrent headaches present with aura or without aura. Various treatment modalities ranging from 5-hydroxytryptamine 1B/1D agonists, non-steroidal anti-inflammatory drugs to steroids are available for acute treatment of migraine. Prophylaxis for chronic cases is usually with β blockers, calcium channel blockers, and antiepileptics. Even many nutraceutical preparations are helpful in migraine including riboflavin, vitamin b12. This review focuses on the newer agents available for treatment of migraine with some sight into their clinical trials

A CASE REPORT OF NADROPARIN INDUCED HYPERKALEMIA

ABSTRACTNadroparin, a low molecular weight heparin, has prophylactic and therapeutic use in thromboembolic disorder. In a patient with carcinoma ovarystage 3 B, nadroparin was given prophylactically for deep vein thrombosis (DVT) before and after interval cytoreduction surgery. Nadroparin 0.3 mlwas given subcutaneously once daily for 1 day preoperatively and 8 days postoperatively. Rise in serum potassium was observed on the third postoperativedaysuggestiveof hyperkalemia.Intravenousfluids weregiven,and thedrug wasstoppedon the 9 post-operative day and hyperkalemiaresolved after 2 days. Monitoring of serum potassium level is essential when Nadroparin is administered prophylactically for more than 7 days forDVT. As this case illustrates a causal relationship between nadroparin and hyperkalemia, caution must be exercised with nadroparin.Keywords: Nadroparin, Hyperkalemia, Thrombosis.t

ISONIAZID THE CULPRIT BEHIND TOXIC OPTIC NEUROPATHY

 Literature regarding toxic optic neuropathy (TON) due to isoniazid (INH) is scarce. This diagnosis is often missed, leading to unnecessary delay in institution of corrective measures. Often, this delay can worsen the patient's vision, with a high likelihood of development of serious damage to the patient's vision. We report a case of a 49-year-old gentleman, afflicted with meningeal tuberculosis, who developed visual disturbances following the administration of antitubercular therapy. The patient's vision improved dramatically following INH's withdrawal. This case highlighted the need to keep INH as a possible cause for TON, especially if vision does not improve following ethambutol's withdrawal. Further, this case attests to the need for thorough and periodic visual examinations in patients receiving antitubercular therapy.Â

Rabeprazole induced Fixed Drug Eruption: A rare case report

Among cutaneous adverse drug reactions, fixed drug eruption is the most common cutaneous drug reaction among the Indian population. The drugsmost commonly implicated in fixed drug eruption are analgesics and antibiotics. Here, we report a case of fixed drug reaction caused by rabeprazole.  Â

ACECLOFENAC-INDUCED STEVENS-JOHNSON SYNDROME AFTER ONE SINGLE DOSE: A MAIDEN CASE REPORT

Drugs are known to cause various adverse drug reactions involving major organ systems. Skin-related adverse reactions are very common and range from a simple rash to life-threatening condition like Stevens-Johnson syndrome. Various drugs are known to cause skin reactions which include antiepileptics, analgesics, antibiotics, and proton-pump inhibitors. Nonsteroidal anti-inflammatory drugs causing life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis are very rare and only few case reports are published. Hence, we report a case of Aceclofenac-induced Stevens-Johnson syndrome after single time administration in a tertiary care hospital in India