An Efficient Approach for Automatic Rectangular Building Extraction From Very High Resolution Optical Satellite Imagery

This letter presents a new approach for rapid automatic building extraction from very high resolution (VHR) optical satellite imagery. The proposed method conducts building extraction based on distinctive image primitives such as lines and line intersections. The optimized framework consists of three stages: First, a developed edge-preserving bilateral filter is adopted to reduce noise and enhance building edge contrast for preprocessing. Second, a state-of-the-art line segment detector called EDLines is introduced for the real-time accurate extraction of building line segments. Finally, we present a graph search-based perceptual grouping approach to hierarchically group previously detected line segments into candidate rectangular buildings. The recursive process was improved through the efficient examination of geometrical information with line linking and closed contour search, in order to obtain more reasonable omission and commission rate in building contour grouping. Extensive experiments performed on VHR optical QuickBird imageries justify the effectiveness and robustness of the proposed linear-time procedure with an overall accuracy of 80.9% and completeness of 87.3%. This method does not require user intervention and thereby has the potential to be adopted in online applications and industrial use in the near future.Geochemistry & GeophysicsEngineering, Electrical & ElectronicRemote SensingImaging Science & Photographic TechnologySCI(E)[email protected]

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

AbstractSchizophrenia (SCZ) and bipolar disorder (BD) are highly heritable disorders that share a significant proportion of common risk variation. Understanding the genetic factors underlying the specific symptoms of these disorders will be crucial for improving diagnosis, intervention and treatment. In case-control data consisting of 53,555 cases (20,129 BD, 33,426 SCZ) and 54,065 controls, we identified 114 genome-wide significant loci (GWS) when comparing all cases to controls, of which 41 represented novel findings. Two genome-wide significant loci were identified when comparing SCZ to BD and a third was found when directly incorporating functional information. Regional joint association identified a genomic region of overlapping association in BD and SCZ with disease-independent causal variants indicating a fourth region contributing to differences between these disorders. Regional SNP-heritability analyses demonstrated that the estimated heritability of BD based on the SCZ GWS regions was significantly higher than that based on the average genomic region (91 regions, p = 1.2×10−6) while the inverse was not significant (19 regions, p=0.89). Using our BD and SCZ GWAS we calculated polygenic risk scores and identified several significant correlations with: 1) SCZ subphenotypes: negative symptoms (SCZ, p=3.6×10−6) and manic symptoms (BD, p=2×10−5), 2) BD subphenotypes: psychotic features (SCZ p=1.2×10−10, BD p=5.3×10−5) and age of onset (SCZ p=7.9×10−4). Finally, we show that psychotic features in BD has significant SNP-heritability (h2snp=0.15, SE=0.06), and a significant genetic correlation with SCZ (rg=0.34) in addition there is a significant sign test result between SCZ GWAS and a GWAS of BD cases contrasting those with and without psychotic features (p=0.0038, one-side binomial test). For the first time, we have identified specific loci pointing to a potential role of 4 genes (DARS2,ARFGEF2,DCAKDandGATAD2A) that distinguish between BD and SCZ, providing an opportunity to understand the biology contributing to clinical differences of these disorders. Our results provide the best evidence so far of genomic components distinguishing between BD and SCZ that contribute directly to specific symptom dimensions.</jats:p