EFFECTIVENESS OF MIRROR THERAPY ON UPPER EXTREMITY MOTOR FUNCTIONS (UEMFS) & ACTIVITIES OF DAILY LIVING (ADLS) IN STROKE PATIENTS AT DEPARTMENT OF NEUROLOGY, KGMU LUCKNOW

Background: Stroke, global health problem and second cause of death with fourth leading cause of disability worldwide. Mirror therapy is a new approach in rehabilitation used in different neurological disorders including stroke. In mirror therapy, a mirror is placed beside the unaffected limb, blocking the view of the affected limb. This creates the illusion that both limbs are functioning properly. Objectives: The objective of the study was to assess the effectiveness of mirror therapy on upper extremity motor functions and activity of daily living in stroke patients. Method: A quasi-experimental one group pre-test post-test design used by convenient sampling assign 35-stroke patients who met the inclusion criteria. The intervention administered in the morning for a week and a self-structured tool (UEMFs assessment scale) for Upper extremity motor functions and ADL Independence scale for activity of daily living. Data were collected every day in a week. Results: The result showed that UEMFs score was significant after intervention (p&lt;0.001), ADL score was significant (p&lt;0.001). There was significant improvement from pre to post test was found in UEMFs status among stroke patents (p=0.015). The significant improvement in ADL status among stroke patients. (p=0.003). The significant correlation was found between UEMFs (r=0.737, p&lt;0.001) and ADL (r=0.857, p&lt;0.001). Conclusion: The study concluded that Mirror therapy was an effective, non-pharmacological measure for improving upper extremity motor functions and ADL among stroke patients.</jats:p

REVIEW ON TAIL REGENERATION MECHANISM OF XENOPUS LAEVIS AND CLINOTARSUS CURTIPESAS A THERAPEUTIC MODEL FOR REGENERATIVE MEDICINE

The augmentation of regenerative capability is a powerful method for pursuing for the regulation of degeneration, traumatic injury and cancer. The tadpole, Clinotarsus curtipes and Xenopus laevis is a significant model system for addressing the fundamental regeneration mechanism that enables to understand the key aspects of regeneration medicine. The selected creatures Clinotarsus curtipes and Xenopus laevis could able to obtain both tissue regeneration and scar free healing during larval stage in spite of its predominant loss of such ability during the metamorphic process. Such transient capability associated with the evolutionary correlation with humans creates Clinotarsus curtipes and Xenopus a very good attractive model for uncovering the functional regeneration mechanisms. The study analysed the existing literatures on change in the levels of ROS that is required for the proper wnt-signaling in every regeneration system. Apart from that the paper provided the comprehensive review on the histopathological view, regeneration signals like TGFβ, FGF, BMP, Wnt etc for successful regeneration. Factors that affect the tail regeneration like O2 influx, epigenetics and HDAC activity have also been provided. Significant other such criteria like role of TRKA signaling, profiling and intracellular protein expression followed by its corresponding challenges adds value to the paper.The study presents an overview of Xenopus and Clinotarsus curtipesas a model organism for the research and highlighted the new insights.</jats:p