Correlation Of Clinical Severity Of Oral Lichen Planus With Treatment Prognosis - A Retrospective Institution Based Study

Lichen planus is a chronic mucocutaneous immunologically mediated disease which is triggered by varied etiological agents. Lichen planus shows many clinical features affecting the skin, oral cavity, genital organ, nail and scalp. Lichen planus has well documented clinical findings and histological findings that aid in diagnosis. This retrospective study was done to assess the clinical severity of Oral Lichen Planus (OLP) and compare it to the treatment prognosis of the patients visiting our institution. A total of 60 clinically diagnosed OLP patients were included. Clinical and treatment details were recorded and tabulated using Excel. The collected data were then analyzed by appropriate statistics using SPSS software. The results revealed 60% of the cases to be females with 58.3% accounting for the erosive type of lichen planus. 60% had involvement of bilateral buccal mucosa. Erosive variant showed eight months duration of treatment using systemic steroids. Within the limitations of the study, we observed that  OLP accounts for nearly 28.4% of the OPMD reporting to the institution and females were found to be more commonly affected than males. Erosive lichen planus was the most common variant which exhibited maximum treatment duration. Hence, it is necessary to follow up the OLP patients regularly and to provide a precise treatment which prevents the remission of the disease in these patients.</jats:p

DOSE-DEPENDENT CHRONIC TOXICITY SCREENING OF HINOKITIOL IN ZEBRAFISHES: BEHAVIORAL AND HISTOLOGICAL APPROACH

Objectives: Parkinson’s disease (PD) is categorized as a movement disorder symptomized by weakening the motor skills of the patients. The root cause of the disease is the neurodegenerative dopaminergic loss in the substantia nigra of the patient’s brain. This havoc disease majorly affects the people above the age of 60 years. Moreover, PD incidences strike almost 70% of the neurological disorders of the aged population worldwide. There are no perfect curative drugs in the medical world for the disease. Since the past few decades, several plant secondary compounds were in preclinical trials to treat this disease. Hinokitiol (HIN), a monoterpenoid from the heartwood of cupressaceous plants, is widely used in hair tonics, toothpaste, cosmetics, and food as an antimicrobial agent. It is well reported as an anti-stroke agent as well.&#x0D; Methods: In the present study, the dose-dependent (5, 10, 15, 20, and 25 mg/kg) chronic toxicity of HIN was studied for 28 days using zebrafishes. The toxicity was analyzed in vital organs such as brain, liver, kidney, spleen, heart, and blood count followed by behavioral toxicity to target the drug against parkinsonism.&#x0D; Results: The study revealed that the higher doses of 20 and 25 mg/kg HIN treatment were toxic to the fish brain, spleen, as well as cardiomyocytes. It showed a variation in blood count as well at 10 mg/kg dose itself.&#x0D; Conclusion: Hence, the study revealed the protective efficacy of the HIN at its therapeutic dosage of 5 mg/kg as a neuroprotective drug, with minimal vital organ toxicities.</jats:p

Electronic Travel Aid for Visually Impaired People Along with a Panic Alert System

There are many issues over which humans have no control. Blindness is one of such issues. It snatches the vivid visual beauty of the world from an individual’s life.But missing the beauty of nature becomes one of the last worries of such people as they have to face numerous difficulties in order to perform even the most basics of tasks in their day to day life. One of their most important problems is of transport, such as crossing roads, traveling in trains, or in any other public places. A visually impaired person to survive the fittest in this world, the person must go through all the obstacles without the guidance of others. One of the most important measures to avoid the obstacle by the blind is to provide an assistive implementation, which can help to wander on their own. The main aim of this project is to provide an assistive technology used for the purpose of enhancing the mobility of the blind pedestrian which is commonly referred to as Electronic Travel Aid (ETA) and to motivate the blind without having the inferior feeling of their problem and pay away the blind to move on their own . In this project, a smart guiding ETA is used to guide the user to sense the obstacle before them. This device eliminates the requirement of human assistance for blind while traveling outside. It will identify all obstacles in the path with the help of various sensors installed in it. The microcontroller will retrieve data and pass it on as vibrations which will notify the user about hurdles.</jats:p

Review article on sleep apnea

Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that involves a reduces or complete halt in airflow despite an ongoing effort to breathe. It occurs when the muscles relax during sleep, causing soft tissue in the back of the throat to collapse and block the upper airway. This results in partial reductions (hypopneas) and complete block (apneas) in breathing that lasts a minimum of 10 seconds during sleep. Most pauses last between 10 and 30 seconds, but some may persist for one minute or longer. This can cause abrupt reductions in blood oxygen saturation. The brain responds to the lack of oxygen by alerting the body, causing a brief arousal from sleep that restores normal breathing. This pattern can occur many times in one night. The result is a fragmented quality of sleep that often produces an excessive level of daytime sleepiness. Most people with OSA snore loudly and regullarly, with periods of silence when airflow is reduced or blocked. They then make choking, snorting or gasping sounds when their airway reopens. A common measurement of sleep apnea is the apnea-hypopnea index (AHI).</jats:p

Relocating Colonial Women in Resistance: An Interpretation of Rabindranath Tagore’s Nastanirh and Chaturanga

The Colonial Bengal of the nineteenth and twentieth centuries was a place of contradictions. For instance, despite certain evident advancements in the resolution of the women’s question, some of the emancipatory attempts of the period marked a rather dubious account of women’s liberation as patriarchal underpinnings hegemonized the efforts. Amid this complex backdrop, the colonial women’s position is further jeopardized by the western feminist scholarship that contrives colonial third world women as perennial victims and beneficiaries of emancipatory actions from the West. The paper attempts to relocate the colonial women and their resistance by negotiating the fissures in their construction. This study, informed by bell hooks’ (1990) postulations on margin and resistance, simultaneously seeks to form a bridge between the experiences of marginalized women beyond borders. Rabindranath Tagore’s Nastanirh (1901) and Chaturanga (1916) are chosen for close textual reading to examine the experiences of colonial women. The author’s women protagonists often embody the social dilemma of the period. Tagore’s Damini and Charu exist in the margin of resistance whilst Nanibala occupies the margin of deprivation. Significantly, Charu and Damini traverse the precarious “profound edges” of the margin to imagine a “new world” free of subjugation. Thus, the resistance offered by these women subverts the predominant conceptions of victimhood of colonial women, and it enables them to be posited as active agents.</jats:p