GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder affecting 0.5–2% of pregnancies. The majority of cases present in the third trimester with pruritus, elevated serum bile acids and abnormal serum liver tests. ICP is associated with an increased risk of adverse outcomes, including spontaneous preterm birth and stillbirth. Whilst rare mutations affecting hepatobiliary transporters contribute to the aetiology of ICP, the role of common genetic variation in ICP has not been systematically characterised to date. Here, we perform genome-wide association studies (GWAS) and meta-analyses for ICP across three studies including 1138 cases and 153,642 controls. Eleven loci achieve genome-wide significance and have been further investigated and fine-mapped using functional genomics approaches. Our results pinpoint common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements as contributing mechanisms to ICP susceptibility

Face Mask Detection Using Artificial Neural Network

As per the current situation of Coronavirus pandemic many has been affected with this contamination. As per the World Health Organization (WHO), there are numerous side effects that influence us. Thus, in this pandemic each nation, specialists all are saying that each individual should wear cover, use sanitizer and keep up with social removing for other people and to be a long way from infection warmth. According to this, when the pandemic will be open, people will be aggregated in a social event in specific spots like bistro, retail plazas and significantly more places. Thus, we can't track down individuals without veil in the colossal social event of people. I had developed an AI model which will deduct the person without veil. This model is been made by the ARTIFICAL Neural Network, Python, open-cv. Keywords - Python, Artificial intelligence, open cv, webcam, python libraries Keywords - Python, Artificial intelligence, open cv, webcam, python libraries.</jats:p