68 research outputs found
Lifetime hypertension as a predictor of brain structure in older adults: cohort study with a 28-year follow-up.
BACKGROUND: Hypertension is associated with an increased risk of dementia and depression with uncertain longitudinal associations with brain structure. AIMS: To examine lifetime blood pressure as a predictor of brain structure in old age. METHOD: A total of 190 participants (mean age 69.3 years) from the Whitehall II study were screened for hypertension six times (1985-2013). In 2012-2013, participants had a 3T-magnetic resonance imaging (MRI) brain scan. Data from the MRI were analysed using automated and visual measures of global atrophy, hippocampal atrophy and white matter hyperintensities. RESULTS: Longitudinally, higher mean arterial pressure predicted increased automated white matter hyperintensities (P<0.002). Cross-sectionally, hypertensive participants had increased automated white matter hyperintensities and visually rated deep white matter hyperintensities. There was no significant association with global or hippocampal atrophy. CONCLUSIONS: Long-term exposure to high blood pressure predicts hyperintensities, particularly in deep white matter. The greatest changes are seen in those with severe forms of hypertension, suggesting a dose-response pattern
Percutaneous coronary angioscopic comparison of thrombus formation during percutaneous coronary angioplasty with ionic and nonionic low osmolality contrast media in unstable angina
Economic and ethical issues of interventional cardiology in The Netherlands:It is time for managed care
REOCCLUSION 3 MONTHS AFTER SUCCESSFUL THROMBOLYTIC TREATMENT OF ACUTE MYOCARDIAL-INFARCTION WITH ANISOYLATED PLASMINOGEN STREPTOKINASE ACTIVATING COMPLEX
EARLY STENT OCCLUSION IS NOT ALWAYS CAUSED BY THROMBOSIS
Early occlusion of intracoronary stents has been exclusively attributed to thrombosis. Using intracoronary angioscopy, we have found 2 patients in whom this common and serious complication of coronary stenting was caused by obstructive intima dissection rather than thrombosis
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