43 research outputs found
Glycosylation of onconase increases its conformational stability and toxicity for cancer cells
Full text linkProductive and nonproductive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2′,5′)guanosine
Full text link"Productive and non-productive binding to ribonuclease A: X-ray structure of two complexes with uridylyl(2',5') guanosine"
Full text linkProtein Science, vol.9, n.6 1217-1225 (2000
Contribution of a tyrosine side chain to ribonuclease A catalysis and stability-Contribution of Tyr 97 to RNase A catalysis and stability
Full text linkFunctional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A
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Bacillithiol is an antioxidant thiol produced in Bacilli
Get PDFGlutathione is a nearly ubiquitous low-molecular-weight thiol and antioxidant, although it is conspicuously absent from most Gram-positive bacteria. We identify here the structure of bacillithiol, a novel and abundant thiol produced by Bacillus species, Staphylococcus aureus, and Deinococcus radiodurans. Bacillithiol is the α-anomeric glycoside of l-cysteinyl-d-glucosamine with l-malic acid and likely functions as an antioxidant. Bacillithiol, like structurally similar mycothiol, may serve as a substitute for glutathione
