Murine For a Bad Time: Prehospital Factor Associations With Murine Typhus Related ICU Admission

Introduction: Across South Texas rates of murine typhus related hospitalization have been on the rise (1). Murine typhus is flea borne febrile illness caused by the bacterium Rickettsia typhi. Murine typhus is easily treated with doxycycline but is commonly underdiagnosed (2). Rarely murine typhus can cause hospitalization and ICU admission (3). To gain a greater understanding of the clinical course of severe murine typhus, our team has set out to identify novel clinical findings associated severe murine typhus courses. Methods: Medical records were obtained from adults with suspected murine typhus admitted to Doctor’s Hospital at Renaissance in Edinburg, Texas, between 01/01/2010 to 05/31/2020. Authors performed manual chart review on the patients meeting the inclusion criteria and documented aspects of the patient’s medical history. Descriptive statistics were calculated with a χ2 test, were P values =0.05 were considered statistically significant. Results: We enrolled 198 hospitalized adults with suspected murine typhus in our study, 22 requiring ICU admission. No statistically significant relationships were found between ICU admission and PMH indications of: CKD, T2D, HTN, CAD or liver disease. Our results did not show significant relationships between ICU admission and sex, age, or insurance status. Conclusion: Our study did not identify statistically significant relationships between adults admitted to the ICU with suspected murine typhus and health history. The findings of our study may be useful for clinicians who practice in regions endemic to murine typhus. Our team will continue to attempt to identify clinical and laboratory findings associated with a more severe disease course of murine typhus

Virtual Simulation Training Using the Storz C-HUB to Support Distance Airway Training for the Spanish Medical Corps and NATO Partners

In medicine, the advancement of new technologies creates challenges to providers both in learning and in maintaining competency in required skills. For those medical providers located in remote environments, access to learning can be even more formidable. This work describes a collaboration created to facilitate the use of new communication technologies in providing distance training and support to health care personnel deployed in remote areas

El ADNe. La tecnología algorítmica que cambia el modelo educativo para siempre

[ES] El objetivo de este artículo es mostrar una nueva herramienta capaz de garantizar una formación personalizada, predictiva, preventiva y precisa basada en el análisis del persotipo del ADN emocional (ADNe), lo que nos permite identificar la adecuación que posee y el método de corrección requerido en cada individuo para asimilar conocimientos teóricos y prácticos. Su utilidad en el es enorme al permitir una completa gestión del talento individual y colectivo con respecto a los logros académicos y profesionales a alcanzarAzulay, E.; Del Real, H.; Morant-Martínez, O.; Marín-Roig Ramón, J.; Santandreu Mascarell, C. (2018). El ADNe. La tecnología algorítmica que cambia el modelo educativo para siempre. Journal of Management and Business Education (JMBE). 1(2):41-63. http://hdl.handle.net/10251/121786S41631

Domain Wall Propagation and Pinning Induced by Current Pulses in Cylindrical Modulated Nanowires

The future developments of three-dimensional magnetic nanotechnology require the control of domain wall dynamics by means of current pulses. While this has been extensively studied in planar magnetic strips (planar nanowires), few reports exist in cylindrical geometry, where Bloch point domain walls are expected to have intriguing properties. Here we report this investigation in cylindrical magnetic Ni nanowires with geometrical notches. Experimental work based on synchrotron X-ray magnetic circular dichroism (XMCD) combined with photoemission electron microscopy (PEEM) indicates that large current densities induce domain wall nucleation while smaller currents move domain walls preferably against the current direction. In the region where no pinning centers are present we found domain wall velocity of about 1 km/s. The domain wall motion along current was also detected in the vicinity of the notch region. Pinning of domain walls has been observed not only at geometrical constrictions but also outside of them. Thermal modelling indicates that large current densities temporarily raise the temperature in the nanowire above the Curie temperature leading to nucleation of domain walls during the system cooling. Micromagnetic modelling with spin-torque effect shows that for intermediate current densities Bloch point domain walls with chirality parallel to the Oersted field propagate antiparallel to the current direction. In other cases, domain walls can be bounced from the notches and/or get pinned outside their positions. We thus find that current is not only responsible for the domain wall propagation but is also a source of pinning due to the Oersted field action

Basolateral amygdala-ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive-compulsive disorder

Background: cognitive behavioural therapy (CBT), including exposure and ritual prevention, is a first-line treatment for obsessive-compulsive disorder (OCD), but few reliable predictors of CBT outcome have been identified. Based on research in animal models, we hypothesized that individual differences in basolateral amygdala-ventromedial prefrontal cortex (BLA-vmPFC) communication would predict CBT outcome in patients with OCD. Methods: we investigated whether BLA-vmPFC resting-state functional connectivity (rs-fc) predicts CBT outcome in patients with OCD. We assessed BLA-vmPFC rs-fc in patients with OCD on a stable dose of a selective serotonin reuptake inhibitor who then received CBT and in healthy control participants. Results: we included 73 patients with OCD and 84 healthy controls in our study. Decreased BLA-vmPFC rs-fc predicted a better CBT outcome in patients with OCD and was also detected in those with OCD compared with healthy participants. Additional analyses revealed that decreased BLA-vmPFC rs-fc uniquely characterized the patients with OCD who responded to CBT. Limitations: we used a sample of convenience, and all patients were receiving pharmacological treatment for OCD. Conclusion: in this large sample of patients with OCD, BLA-vmPFC functional connectivity predicted CBT outcome. These results suggest that future research should investigate the potential of BLA-vmPFC pathways to inform treatment selection for CBT across patients with OCD and anxiety disorders

Improved FIFRELIN de-excitation model for neutrino applications

The precise modeling of the de-excitation of Gd isotopes is of great interest for experimental studies of neutrinos using Gd-loaded organic liquid scintillators. The FIFRELIN code was recently used within the purposes of the STEREO experiment for the modeling of the Gd de-excitation after neutron capture in order to achieve a good control of the detection efficiency. In this work, we report on the recent additions in the FIFRELIN de-excitation model with the purpose of enhancing further the de-excitation description. Experimental transition intensities from EGAF database are now included in the FIFRELIN cascades, in order to improve the description of the higher energy part of the spectrum. Furthermore, the angular correlations between {\gamma} rays are now implemented in FIFRELIN, to account for the relative anisotropies between them. In addition, conversion electrons are now treated more precisely in the whole spectrum range, while the subsequent emission of X rays is also accounted for. The impact of the aforementioned improvements in FIFRELIN is tested by simulating neutron captures in various positions inside the STEREO detector. A repository of up-to-date FIFRELIN simulations of the Gd isotopes is made available for the community, with the possibility of expanding for other isotopes which can be suitable for different applications.Comment: Corrected typos on author names on arXiv metadat

Performance of prototypes for the ALICE electromagnetic calorimeter

The performance of prototypes for the ALICE electromagnetic sampling calorimeter has been studied in test beam measurements at FNAL and CERN. A $4\times4$ array of final design modules showed an energy resolution of about 11% /$\sqrt{E(\mathrm{GeV})}$ $\oplus$ 1.7 % with a uniformity of the response to electrons of 1% and a good linearity in the energy range from 10 to 100 GeV. The electromagnetic shower position resolution was found to be described by 1.5 mm $\oplus$ 5.3 mm /$\sqrt{E \mathrm{(GeV)}}$. For an electron identification efficiency of 90% a hadron rejection factor of $>600$ was obtained.Comment: 10 pages, 10 figure

Statins Disrupt CCR5 and RANTES Expression Levels in CD4(+) T Lymphocytes In Vitro and Preferentially Decrease Infection of R5 Versus X4 HIV-1

BACKGROUND: Statins have previously been shown to reduce the in vitro infection of human immunodeficiency virus type 1 (HIV-1) through modulation of Rho GTPase activity and lipid raft formation at the cell surface, as well as by disrupting LFA-1 incorporation into viral particles. PRINCIPLE FINDINGS: Here we demonstrate that treatment of an enriched CD4(+) lymphocyte population with lovastatin (Lov), mevastatin (Mev) and simvastatin (activated and non-activated, Sim(A) and Sim(N), respectively) can reduce the cell surface expression of the CC-chemokine receptor CCR5 (P<0.01 for Sim(A) and Lov). The lowered CCR5 expression was associated with down-regulation of CCR5 mRNA expression. The CC-chemokine RANTES protein and mRNA expression levels were slightly increased in CD4(+) enriched lymphocytes treated with statins. Both R5 and X4 HIV-1 were reduced for their infection of statin-treated cells; however, in cultures where statins were removed and where a decrease in CCR5 expression was observed, there was a preferential inhibition of infection with an R5 versus X4 virus. CONCLUSIONS: The results indicate that the modulation of CC-chemokine receptor (CCR5) and CC-chemokine (RANTES) expression levels should be considered as contributing to the anti-viral effects of statins, preferentially inhibiting R5 viruses. This observation, in combination with the immunomodulatory activity exerted by statins, suggests they may possess more potent anti-HIV-1 activity when applied during the early stages of infection or in lowering viral transmission. Alternatively, statin treatment could be considered as a way to modulate immune induction such as during vaccination protocols

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286