Emerging topics in Brexit debate on Twitter around the deadlines a probabilistic topic modelling approach

The present study is focused on the online debate relating to the Brexit process, three years and half since the historical referendum that has sanctioned the divide of the United Kingdom from the European Union. In our analysis we consider a corpus of approximately 33 million Brexit related tweets, shared on Twitter for 58 weeks, spanning from 31 December 2019 to 9 February 2020. Due to its great accessibility to data, Twitter constitutes a convenient data source to monitor and evaluate a wide variety of topics. In addition, Twitter’s marked orientation towards news and the dissemination of information makes this microblogging network more connected to politics compared to other platforms. Through static and dynamic topic modelling techniques, we were able to identify the topics that have attracted the most attention from Twitters users and to characterise their temporal evolution. The topics retrieved by the static model highlight the major events of the Brexit process while the dynamic analysis recovered the persistent themes of discussion and debate over the entire period

Pulmonary squamous cell carcinoma with lepidic growth pattern : new insights into lung cancer classification

Lung squamous cell carcinoma (SCC) has always been considered a monomorphic entity, different from lung adenocarcinoma which is known to be a very heterogeneous tumor from morphological and molecular point of view. Just two histological subtypes of SCC are recognised, the basaloid and lymphoepithelioma-like histotypes, as in other sites different from the lung. Recently, different studies tried to expand the classification of SCC by adding different subtypes based on morphological characteristics (such as keratinization or clear cell features) or different growth patterns (papillary or basaloid). We report a case of squamous cell carcinoma with a previously unreported, distinctive and predominant "lepidic" growth pattern, with its immunophenotypical and molecular characterization

Isolation and characterization of two newly established thymoma PDXs from two relapses of the same patient: a new tool to investigate thymic malignancies

BackgroundThymic malignancies are a heterogeneous group of rare cancers for which systemic chemotherapy is the standard treatment in the setting of advanced, recurrent or refractory diseases. Both environmental and genetic risk factors have not been fully clarified and few target-specific drugs have been developed for thymic epithelial tumors. A major challenge in studying thymic epithelial tumors is the lack of preclinical models for translational studies.Main bodyStarting from bioptic material of two consecutive recurrences of the same patient, we generated two patient-derived xenografts. The patient-derived xenografts models were characterized for histology by immunohistochemistry and mutations using next-generation sequencing. When compared to the original tumors resected from the patient, the two patient-derived xenografts had preserved morphology after the stain with hematoxylin and eosin, although there was a moderate degree of de-differentiation. From a molecular point of view, the two patient-derived xenografts maintained 74.3 and 61.8% of the mutations present in the human tumor of origin.Short conclusionThe newly generated patient-derived xenografts recapitulate both the molecular characteristics and the evolution of the thymoma it derives from well, allowing to address open questions for this rare cancer

Human case of autochthonous West Nile virus lineage 2 infection in Italy, September 2011.

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Synchronous pleural and peritoneal malignant mesothelioma : a case report and review of literature

The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease

Cartographies of the Body in Pandemic Times

As Fox and Alldred (2020) note, culture/nature dualism has supplied post-Enlightenment philosophers, scientists and social scientists with a neat way to set limits on the respective Cartographies of the Body in Pandemic Times Saúde em Redes. 2022; 8 (3) 494 concerns of the social and natural sciences (see also Barad, 2007; Braidotti, 2013; Fullagar et al., 2019). This dualism has also enabled the creation of distinctions between “modern” (read “civilised”) and “traditional” (read “primitive”) bodies and ways of being-in-the-world. Yet, when critically exploring issues of embodiment, the influence of the built environment on well-being, climate transitions and/or the ongoing Covid-19 pandemic such distinctions start to become problematic, as eloquently argued in the last three decades by feminist, post-human, newmaterialist and political ecological –among others– debates and propositions. Giving continuity to an ongoing dialogue started in 2018 between scholars and activists from Latin America and Europe, we organized the online seminar “Re-assembling the nature-culture-body nexus: practices and epistemologies”. In this two-parts online event was explored how the interrelated domains of health, physical activity, and education can look like from perspectives that de-stabilise established ontological boundaries between nature, culture, the body, and their relationship. This paper is the transcription of the second session, called “Cartographies of the body in pandemic times”, and present the dialogues between Alice del Gobbo, Carla Panico, Gianluca De Fazio, Alexandre Fernandez Vaz and Eduardo Galak, researchers from Brazil, Italy Portugal and Argentina