The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism.

Causes and contributing factors for autism are poorly understood. Evidence suggests that prevalence is rising, but the extent to which diagnostic changes and improvements in ascertainment contribute to this increase is unclear. Both genetic and environmental factors are likely to contribute etiologically. Evidence from twin, family, and genetic studies supports a role for an inherited predisposition to the development of autism. Nonetheless, clinical, neuroanatomic, neurophysiologic, and epidemiologic studies suggest that gene penetrance and expression may be influenced, in some cases strongly, by the prenatal and early postnatal environmental milieu. Sporadic studies link autism to xenobiotic chemicals and/or viruses, but few methodologically rigorous investigations have been undertaken. In light of major gaps in understanding of autism, a large case-control investigation of underlying environmental and genetic causes for autism and triggers of regression has been launched. The CHARGE (Childhood Autism Risks from Genetics and Environment) study will address a wide spectrum of chemical and biologic exposures, susceptibility factors, and their interactions. Phenotypic variation among children with autism will be explored, as will similarities and differences with developmental delay. The CHARGE study infrastructure includes detailed developmental assessments, medical information, questionnaire data, and biologic specimens. The CHARGE study is linked to University of California-Davis Center for Children's Environmental Health laboratories in immunology, xenobiotic measurement, cell signaling, genomics, and proteomics. The goals, study design, and data collection protocols are described, as well as preliminary demographic data on study participants and on diagnoses of those recruited through the California Department of Developmental Services Regional Center System

Impact of spin-orbit coupling on quantum Hall nematic phases

Anisotropic charge transport is observed in a two-dimensional (2D) hole system in a perpendicular magnetic field at filling factors nu=7/2, nu=11/2, and nu=13/2 at low temperature. In stark contrast, the transport at nu=9/2 is isotropic for all temperatures. Isotropic hole transport at nu=7/2 is restored for sufficiently low 2D densities or an asymmetric confining potential. The density and symmetry dependences of the observed anisotropies suggest that strong spin-orbit coupling in the hole system contributes to the unusual transport behavior.Comment: 4 pages, 4 figure

Observation of a One-Dimensional Spin-Orbit Gap in a Quantum Wire

Understanding the flow of spins in magnetic layered structures has enabled an increase in data storage density in hard drives over the past decade of more than two orders of magnitude1. Following this remarkable success, the field of 'spintronics' or spin-based electronics is moving beyond effects based on local spin polarisation and is turning its attention to spin-orbit interaction (SOI) effects, which hold promise for the production, detection and manipulation of spin currents, allowing coherent transmission of information within a device. While SOI-induced spin transport effects have been observed in two- and three-dimensional samples, these have been subtle and elusive, often detected only indirectly in electrical transport or else with more sophisticated techniques. Here we present the first observation of a predicted 'spin-orbit gap' in a one-dimensional sample, where counter-propagating spins, constituting a spin current, are accompanied by a clear signal in the easily-measured linear conductance of the system.Comment: 10 pages, 5 figures, supplementary informatio

Theory of suppressed shot-noise at ν=2/(2p+χ)\nu=2/(2p+\chi)

We study the edge states of fractional quantum Hall liquid at bulk filling factor $\nu=2/(2p+\chi)$ with $p$ being an even integer and $\chi=\pm 1$. We describe the transition from a conductance plateau $G=\nu G_0=\nu e^2/h$ to another plateau $G=G_0/(p+\chi)$ in terms of chiral Tomonaga-Luttinger liquid theory. It is found that the fractional charge $q$ which appears in the classical shot-noise formula $S_{I}=2q$ is $q=e/(2p+\chi)$ on the conductance plateau at $G=\nu G_0$ whereas on the plateau at $G=G_0/(p+\chi)$ it is given by $q=e/(p+\chi)$. For $p=2$ and $\chi=-1$ an alternative hierarchy constructions is also discussed to explain the suppressed shot-noise experiment at bulk filling factor $\nu=2/3$.Comment: Typos in Eqs. (5-7) correcte

Colored noise in the fractional Hall effect: duality relations and exact results

We study noise in the problem of tunneling between fractional quantum Hall edge states within a four probe geometry. We explore the implications of the strong-weak coupling duality symmetry existent in this problem for relating the various density-density auto-correlations and cross-correlations between the four terminals. We identify correlations that transform as either ``odd'' or ``anti-symmetric'', or ``even'' or ``symmetric'' quantities under duality. We show that the low frequency noise is colored, and that the deviations from white noise are exactly related to the differential conductance. We show explicitly that the relationship between the slope of the low frequency noise spectrum and the differential conductance follows from an identity that holds to {\it all} orders in perturbation theory, supporting the results implied by the duality symmetry. This generalizes the results of quantum supression of the finite frequency noise spectrum to Luttinger liquids and fractional statistics quasiparticles.Comment: 14 pages, 3 figure