Anatomy of condorchelys antiqua sterli, 2008, and the origin of the modern jaw closure mechanism in turtles

Here we present a detailed anatomical description of cranial and post-cranial remains of a Jurassic turtle, Condorchelys antiqua Sterli, 2008, from the Caadn Asfalto Formation (Middle Jurassic) in central Patagonia. Although C. antiqua is similar in morphology to the Early Jurassic turtles Kayentachelys aprix and Indochelys spatulata, it differs in that it lacks both pterygoid teeth and a V-shaped suprapygal 2, respectively. In light of new discoveries and reinterpretations of other fossil taxa, we suggest that several changes in the evolution of the skull morphology of turtles (such as the closure of the basipterygoid articulation, the closure of the interpterygoid vacuity, the development of the secondary lateral wall in the braincase, the development of temporal emargination and/or the posterior extension of the crista supraoccipitalis) could be related to the acquisition of a stronger skull to accommodate the modern pulley system. The optimization of these characters in a phylogenetic framework shows that they are coincident with the appearance of trochlear systems (oticum or pterygoidei) in turtles, suggesting a functionally correlated relationship among them.Fil: Sterli, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; Argentina. Museo Paleontológico Egidio Feruglio; ArgentinaFil: de la Fuente, Marcelo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; Argentin

Museums and institutions of natural sciences in the south of the province of Mendoza and their contribution to argentine paleoherpetology

Las dos instituciones más relevantes dedicadas a la promoción de las ciencias naturales en el sur de la provincia de Mendoza son el Museo de Historia Natural de San Rafael (MHNSR) (Departamento de San Rafael) y el Museo Regional de Malargüe “Jorge Luna” (MRM)(Departamento de Malargüe). La primera institución fue fundada en el año 1955 mientras que la segunda se erigió en el año 1973 y ambas se incorporaron a la órbita municipal en los primeros años de la década del ‘70 del siglo pasado. Estos museos han tenido un diferente desarrollo y proyección en lo que respecta a su actividad científica. Esto también se reflejó en el desarrollo de la paleoherpotología en el MHNSR con la incorporación de investigadores y becarios del CONICET acontecida a partir del año 2002. En el año 2006 se originó el Centro Regional de Investigación y Desarrollo Cultural, institución que desarrolló actividades paleontológicas en Malargüe principalmente entre los años 2006 y2015. Con la reciente creación del Instituto de Evolución, Ecología Histórica y Ambiente, unidad ejecutora de doble dependencia CONICET y Universidad Tecnológica Nacional, los paleontólogos continuaron su desempeño en esta unidad sin dejar el MHNSR, donde se alojan las colecciones paleontológicas. En el MRM, las colecciones se encuentran tanto en el antiguo molino del casco de la estancia “La Orteguina”,edificación colindante, y en la sala de exposición de paleontología de dicho museo. Estas instituciones resguardan pequeñas colecciones de reptiles fósiles.The two most relevant institutions dedicated to the promotion of natural sciences in the south of the Mendoza Province are the Museum of Natural History of San Rafael (MHNSR) (Department of San Rafael) and the Regional Museum of Malargue "Jorge Luna" (MRM) (Department of Malargue). The first institution was founded in 1955 whereas the second one in 1973, and both were incorporated into the municipal management in the first years of the '70s during the last century. These museums have had different trajectories and projections regarding their scientific activity. This was also reflected in the paleoherpetological development at the MHNSR with the incorporation of researchers and fellows from CONICET since 2002. The Regional Center for Cultural Research and Development is an institution that conducted paleontological activities in southern Mendoza Province between the years 2006 and 2015. With the recent creation of the Institute of Evolution, Historical Ecology and Environment, an institute that depends both from CONICET and the National Technological University, paleontologists would continue their work in this unit without leaving the MHNSR, where paleontological collections are housed. For the MRM, fossils are housed both in the adjacent old mill at the estancia "La Orteguina", as well as in the palaeontology exhibition room of this museum. These institutions house small collections of fossil reptiles.Fil: de la Fuente, Marcelo Saul. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; Argentin

Análisis diagenético de tetrápodos del Triásico Superior, Grupo Puesto Viejo, Argentina

The Puesto Viejo Group crops out in the San Rafael Block, southwest Mendoza, Argentina. This group is an important unit for the knowledge theTriassic faunas. It is composed of basal Quebrada de los Fósiles Formation (QF) overlying by the Río Seco de la Quebrada Formation (RSQ). In this study, we report tetrapod remains from the RSQ Formation that includes, until now, exclusively therapsids. Non-mammalian therapsids predominated in terrestrial ecosystems during the Late Paleozoic and Early Mesozoic. Although cynodonts and dicynodonts have been studied from several perspectives, the relation between taxa and sedimentary context has been scarcely documented. This study is aimed to elucidate the diagenesis of tetrapods from the Puesto Viejo Group and its relation to depositional environment. Diagenetic features of therapsid bones from the RSQ Formation were analyzed through thin sections to interpret the degree of taphonomic alteration. Diagenetic processes inferred include substitution; fracturing; brittle deformation and different permineralization events. Combined analyses through scanning electron microscopy; energy-dispersive X-ray spectrometry (SEM-EDX); X-ray diffractometry (XRD) and petrographic studies reveals the substitution of hydroxyapatite by francolite. The presence of fluorine in some samples suggests a link between the elemental composition and depositional environments: floodplain and crevasse splay. Permineralization stages include infilling of vascular canals, trabeculae and fractures with iron oxides and iron carbonate minerals during the burial history. This contribution represents a relevant approach to elucidate the relation between diagenesis on tetrapods and their paleoenvironments, as exemplified in this case study from the Puesto Viejo Group during the Upper Triassic.El Grupo Puesto Viejo aflora en el Bloque San Rafael, en el suroeste de Mendoza, Argentina. Este grupo constituye una importante unidad para el conocimiento de las faunas del Triásico y está compuesto en su base, por la Formación Quebrada de los Fósiles (QF), superpuesta por la Formación Río Seco de la Quebrada (RSQ). En este estudio, se reportan restos de tetrápodos de la Formación RSQ que incluye, hasta ahora, exclusivamente terápsidos. Los terápsidos no-mamiferoides predominaron en los ecosistemas terrestres durante el Paleozoico tardío y el Mesozoico temprano. A pesar de que cinodontes y dicinodontes han sido estudiados desde varias perspectivas, la relación entre los taxones y su contexto sedimentario está escasamente documentado. Este estudio tiene como objetivo dilucidar la diagénesis de los tetrápodos del grupo Puesto Viejo y su relación con el ambiente depositacional. Las características diagenéticas de los huesos de terápsidos de la Formación RSQ se analizaron a través de secciones delgadas para interpretar el grado de alteración tafonómica. Los procesos diagenéticos inferidos incluyen la sustitución, fracturación, deformación frágil y diferentes eventos de permineralización. El análisis combinado a través de microscopía electrónica de barrido, espectrometría de rayos X de energía dispersiva (SEM-EDX), difractometría de rayos X (DRX) y estudios petrográficos revelaron la sustitución de la hidroxiapatita por francolita. La presencia de flúor en algunas muestras sugiere la vinculación entre la composición elemental y los ambientes depositacionales: llanura de inundación y lóbulo de desbordamiento. Las etapas de permineralización incluyen el relleno de canales vasculares, trabéculas y fracturas con óxidos de hierro y carbonatos de hierro durante la historia de enterramiento. Esta contribución representa un enfoque relevante para dilucidar la relación entre la diagénesis de tetrápodos y sus paleoambientes, como lo demuestra este estudio de caso del Grupo Puesto Viejo durante el Triásico Superior.Fil: Previtera, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Mancuso, Adriana Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: de la Fuente, Marcelo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla; ArgentinaFil: Sánchez, Eloy S.. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Laboratorio de Microscopia Electrónica y Microanálisis; Argentin

Testudinoidea Fitzinger (Testudines: cryptodira) of the Toropí/Yupoí Formation (ca. 58-28 ka) in the province of Corrientes, Argentina: taxonomy and paleoenvironmental

Os testudinoideos recuperados da Formação Toropí/Yupoí (ca. 58-28 ka) estão representados por testudinídeos e emidídeos. Estes foram coletados em duas localidades (Província de Corrientes, Argentina): Arroyo Toropí e Santa Lucía. Da primeira localidade procedem dois testudinídeos: o holótipo de Chelonoidis lutzae, composto por partes da carapaça dorsal, plastrão e restos do esqueleto apendicular, e outro exemplar tentativamente assignado a esta espécie que está representado por fragmentos de carapaça dorsal e plastrão. Novos exemplares constituídos por restos fragmentários de testudinídeos (cf. Chelonoidis) e emidídeos (Trachemys cf. dorbigni) procedem de Santa Lucía. A partir da constatação de mapas de distribuição global de espécies atuais de testudinídeos gigantes (e.g. Chelonoidis nigra, Geochelone sulcata, Dipsochelys elephantina y Cylindraspis peltastes) e o mapa climatológico de Kottek e colaboradores se observa una congruência entre a distribuição geográfi ca destas espécies gigantes atuais com as zonas tropical e subtropical caracterizadas por climas quentes, indicando um alto grau de sensibilidade térmica para estas tartarugas terrestres. Esta informação, somada aos dados geológicos e paleontológicos da Formação Toropí/Yupoí, sugere que os Chelonoidis gigantes habitaram na área do Arroyo Toropí e Santa Lucía sob condições climáticas quentes. Por sua vez, condições quentes e úmidas são inferidas a partir da presença de Trachemys cf. T. dorbigni na mesma unidade afl orante em Santa Lucía.Remains of testudinoids from Toropí/Yupoí Formation (ca. 58-28 ka), including testudinids and emydids, were recovered from Arroyo Toropí and Santa Lucía localities (Corrientes Province, northeastern Argentina). From Arroyo Toropí two specimens of testudinid are known: the holotype of Chelonoidis lutzae (carapace, plastron and remains of the appendicular skeleton) and a partial carapace tentatively referred to this species. New specimens including remains of testudinids (cf. Chelonoidis) and emydids (Trachemys cf. T. dorbigni) have been also recovered from Santa Lucía. Comparing the global distribution of extant species of giant testudinids (e.g. Chelonoidis nigra, Geochelone sulcata, Dipsochelys elephantina and Cylindraspis peltastes) with the climate map of Kottek and collaborators, show congruence with the Tropical and Subtropical zones, characterized by warm climate. This suggests a high degree of thermosensitivity for these extant giant tortoises. This, together with the geological and paleontological data from Toropí/Yupoí Formation, allows suggesting that the giant Chelonoidis inhabited environments with warm climate conditions. In addition, warm and wet conditions are inferred in Santa Lucía from the record of Trachemys cf. dorbigni.Fil: Zacarias, Gerardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: de la Fuente, Marcelo Saul. Museo Municipal de Historia Natural San Rafael - Unidad Asociada al CCT Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zurita, Alfredo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; Argentin

The new outfit of Neusticemys neuquina: Holw recent findings and techniques helped clarify its phylogenetic affinities

Neusticemys neuquina is one of the two known turtles from the Upper Jurassic of the Vaca Muerta Formation. Since its initial description in 1988 its taxonomic affinities have been unstable because all known specimens are postcranial elements, which seem to lack phylogenetic relevance. Initially referred, putatively, to the genus Eurysternum, it has also been considered a protostegid or a basal cryptodire. Recently, the discovery and descriptions of three skulls (MOZ 064, MACN-PV 105, MHNSR-PV-1195) and their study using computed tomography helped establish it as a member of Thalassochelydia. The new skulls have in common with Thalassochelydia: the articular process of the quadrate posteriorly oriented; the presence of a prominent, ventrally infolding ridge of the posterior surface of the processus articularis of the quadrate; a long interpterygoid contact; the presence of a pterygoid contact with the articular surfaces of the quadrate; an anterolateral recess of the anterior surface of the quadrate lateral to the processus trochlearis oticum; the presence of a fossa on the supraoccipital-opisthotic-exoccipital contact area; the foramina anterius caroticus cerebralis close together but as independent foramina in the basisphenoid; and the presence of a splenial bone in the mandible. Some of the features that distinguish it from other Thalassochelydia are the presence of a depression on the ventral surface of the basisphenoid, a relatively larger foramen nervi trigemini and reduced and steepened triturating surfaces in both the mandible and maxilla. The mandibular morphology resembles that of Dermochelys coriacea rather than that of other thalassochelydians and panchelonioids, which might indicate similarities in the feeding preferences between these species. New research has shown that thalassochelydians might have been better adapted to marine environments than previously thought and Neusticemys neuquina is not the exception.Fil: González Ruiz, Pablo. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: de la Fuente, Marcelo Saul. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: Fernández, Marta S.. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaTurtle Evolution Symposium 2021TrelewArgentinaMuseo Paleontológico Egidio Ferugli

New remains of Prochelidella in the Anacleto Formation (Campanian levels) of Neuquén basin, Patagonia, Argentina

The new turtle remains presented here were recovered from the Anacleto Formation (Campanian) exposed in the Aguada Grande site. This area is located 10 km south of Rincón de Los Sauces city, inthe north of the province of Neuquén, Patagonia, Argentina. The specimen (MAU-Pv-AG-452)consists of a partially preserved skull, carapace remains, an almost complete plastron, and a leftilium. The new specimen is assigned to Pleurodira because its ilium is sutured to the carapace. Both Parietals, the posterior part of frontals and post orbitals, the dorsal region of the supraoccipital, both pterygoids, the basisphenoid, and part of the prootics are recognized in the skull. The carapace remains are represented by a left first costal bone in articulation with a peripheral bone, a left paired costal bone, and another fragmented coastal. The plastron is represented by both epiplastra, theen plastron, left hyoplastron, both hypoplastra, and the left xiphiplastron. The skull shows somecharacters that allow its referral to Prochelidella spp. (e.g., a developed retropterygoid foramen, and a big muscle attachment area over the basisphenoid). The visceral view of the first costal bone exhibitslong auxiliary buttresses that extend 2/3 of the costal width. This condition is also observed in the costal bone of Prochelidella buitreraensis from the Candeleros Formation (Cenomanian). The scutepattern observed in the anterior lobe of the plastron shows a large gular that extends along theentoplastral length and small extragulars over the epiplastra. In contrast, on the scheme observed inProchelidella cerrobarcinae and Prochelidella portezuelae, the gular does not extend beyond the first third of the entoplastron. The material recovered from the Anacleto Formation represents the most complete specimen outside the Prochelidella peak of diversity range (Albian Cenomanian) and the second skull recognized in this genusFil: Maniel, Ignacio Jorge. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: de la Fuente, Marcelo Saul. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: Filippi, Leonardo Sebastián. No especifíca;Simposio de Evolución de TortugasTrelewArgentinaMuseo Paleontológico Egidio FeruglioAsociación Paleontológica Argentin

El estudio de los reptiles continentales en el Museo de La Plata: Historia, protagonistas y líneas actuales de investigación

El Museo de La Plata tiene una larga trayectoria en el estudio de los reptiles fósiles continentales, representadas por dinosaurios,cocodrilos, tortugas y escamados. Sus estudios se remontan hacia finales del siglo XIX, motorizados por los estudios pioneros de FlorentinoAmeghino, Santiago Roth, Richard Lydekker y Arthur Smith Woodward, principalmente. Durante la primera mitad del siglo XX los estudios deformas continentales son saltuarios, destacándose los aportes de Frederick von Huene y Ángel Cabrera. En la década de 1960 se produjerondos hechos singulares. El primero, Rodolfo Casamiquela que realizó expediciones a Patagonia y generó conocimientos sobre la herpetofaunamesozoica, depositando los especímenes en las colecciones del Museo de La Plata. El segundo, la visión de Rosendo Pascual, profesor y jefede la División Paleontología de Vertebrados, quién a finales de esa década, incentiva a jóvenes postulantes al estudio sobre anfibios, reptiles yaves, conformándose la primera promoción de paleoherpetólogos con títulos académicos y especialidades temáticas: Ana María Báez en anuros,Zulma Brandoni de Gasparini en crocodiliformes y Eduardo P. Tonni en aves. Todos ellos dejaron escuela, la que se advierte claramente en lascamadas de discípulos que aun trabajan en esos clados. A comienzos del siglo XXI se establecen líneas de investigación derivadas del legadode Gasparini, basadas en el estudio de la anatomía, las relaciones filogenéticas y la paleobiología de arcosaurios continentales. Las mismastienen foco en los pseudosuchios y dinosaurios sauropodomorfos, lideradas por Paula Bona, Julia Desojo y Alejandro Otero, todos con lugar detrabajo permanente en la institución.The Museo de La Plata has a long history in the study of continental fossil reptiles, represented by dinosaurs, crocodiles, turtles and squamates. The studies of these groups date back to the end of the 19th century, in all cases driven mainly by the pioneering studies of Florentino Ameghino, Santiago Roth, Richard Lydekker and Arthur Smith Woodward. Such studies extend throughout the 20th century, although sporadically. During the first half of the 20th century, studies on continental forms were scarce, highlighting those of Frederick von Huene and Ángel Cabrera. In the 60’s two important events occur. Firstly, Rodolfo Casamiquela made several expeditions to Patagonia, increasing notably the knowledge on mesozoic paleoherpetofauna, hosting the collections at Museo de La Plata. Secondly, the vision of Rosendo Pascual, professor and head of the División Paleontología de Vertebrados, who encouraged young applicants to study amphibians, reptiles and birds by the end of the 60’s, namely, Ana Maria Báez, Zulma Brandoni de Gasparini and Eduardo P. Tonni, respectively. All of them left a legacy behind, represented today by their disciples that continue the research on those clades. Already at the beginning 21st century, lines of research derived from the legacy of Gasparini have a permanent place of work in the institution, studying the anatomy, phylogenetic relationships and paleobiology of continental South American archosaurs. Such lines are focused on pseudosuchians and sauropodomorph dinosaurs, led by Paula Bona, Julia Desojo and Alejandro Otero.Fil: Otero, Alejandro. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Bona, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: de la Fuente, Marcelo Saul. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: Desojo, Julia Brenda. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentin

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

State of knowledge of the extinc turtles of the argentina territory: a historical peerspective

El estudio de las tortugas extintas en el territorio argentino se inició hace 157 años cuando el naturalista francés Auguste Bravardnominó la primera especie de tortuga. Desde ese entonces hasta la actualidad se incrementó el conocimiento de los Testudinata del territorioargentino en una progresión geométrica, desde las meras nominaciones de especies sin ningún tipo de caracterización, realizadas por los naturalistasy los pioneros de los estudios paleontológicos del siglo XIX, hasta los estudios anatómicos detallados de la actualidad. Arbitrariamentehemos reconocido tres etapas diferentes en el desarrollo de estos estudios. Una etapa inicial que se extendió por más de 100 años y que abarcóentre 1858 y 1965 caracterizada por menciones esporádicas sobre nuevas especies de tortugas fósiles realizadas por naturalistas extranjerosy argentinos, así como por pioneros de la paleontología. Una segunda etapa que abarcó 27 años comprendida entre los años 1966 y 1993 en laque se realizaron mayormente trabajos de síntesis por parte de paleontólogos de vertebrados y paleoherpetólogos argentinos incluyendo, en algunoscasos, la participación de especialistas extranjeros. La última etapa, comprendida entre los años 1994 y 2015, está caracterizada por elestudio sistemático de las tortugas extintas con aportes significativos sobre la anatomía, taxonomía y biogeografía de los Testudinata meso-cenozoicos del territorio argentino.The study of extinct turtles in the Argentine territory began 157 years ago when the French naturalist Auguste Bravard nominated the first species of turtle. Since then, the knowledge of the Testudinata in the Argentine territory increased in a geometric progression from mere nominations of species without any characterization, made by naturalists and pioneers of the paleontological studies of the nineteenth century, to the recent detailed anatomical studies. Three different stages in the history of the study of turtles in Argentina can be recognized. The initial stage, that lasted more than 100 years, between 1858 and 1965, the studies were carried out by foreign and Argentine naturalists as well as by pioneers of paleontology. The second stage that lasted 27 years, between 1966 and 1993 in which synthesis works have mainly done by vertebrate paleontologists and Argentine paleoherpetologists, in some cases with the participation of foreign experts. The last stage, between 1993 and 2015, is characterized by significant contributions on the anatomy, taxonomy and biogeography of Meso–Cenozoic Testudinata of the Argentine territory.Fil: de la Fuente, Marcelo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla | Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael - Ianigla; ArgentinaFil: Sterli, Juliana. Museo Paleontológico Egidio Feruglio; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

New evidence from the Palaeocene of Patagonia (Argentina) on the evolution and palaeobiogeography of Meiolaniformes (Testudinata, new taxon name)

Peligrochelys walshae gen. et sp. nov. is a new stem turtle closely related to the clade Meiolaniidae found in the Palaeocene levels of the Salamanca Formation (Maastrichtian?Danian) of central Patagonia, Chubut Province, Argentina. A phylogenetic analysis shows that Peligrochelys walshae forms a monophyletic group with Mongolochelys efremovi, a clade that, in return, is the sister group of a clade formed by Patagoniaemys gasparinae, Otwayemys cunicularius, Kallokibotion bajazidi and Meiolaniidae. Meiolaniidae is recovered deeply nested in a monophyletic group (Meiolaniformes, newtaxon name) dominated by Gondwanan taxa (e.g. Chubutemys copelloi, Patagoniaemys gasparinae, Otwayemys cunicularius and Peligrochelys walshae), that also includes some notable Laurasian representatives (Mongolochelys efremovi and Kallokibotion bajazidi). The biogeographic scenario presented here supports the hypothesis that this group of turtles may have originated as early as the Early Cretaceous in the South American part of Gondwana. The long ghost lineage that extends below this clade suggests that it may have originated any time between the Early Jurassic and the Early Cretaceous, implying a Pangaean or Gondwanan origin for the clade, respectively. The phylogenetic scenario presented here shows that at least two lineages (Peligrochelys walshae and Meiolaniidae) of Meiolaniformes survived the K?P boundary extinction. Another interesting characteristic of meiolaniform turtles in the fossil record is their frequent association with another clade of strictly Gondwanan distribution, the pleurodiran clade Chelidae. This association is typically found in outcrops from the Early Cretaceous to the Eocene in central Patagonia, and in the Early Cretaceous and from the Miocene to the Pleistocene in Australia.Fil: Sterli, Juliana. Museo Paleontologico Egidio Feruglio; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: de la Fuente, Marcelo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológica Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Museo de Historia Natural de San Rafael; Argentin