Cannabinoids with a propyl side chain in cannabis: occurrence and chromatographic behavior

Contains fulltext : 142265.pdf (publisher's version ) (Open Access

Chemie en farmakokinetiek van hashish en marihuana bestanddelen

Contains fulltext : 142584.pdf (publisher's version ) (Open Access

Cultuurberichtgeving in een tijdperk van globalisering

This article aims at charting and elucidating key developments and cross-national variations in the coverage given to foreign and indigenous cultural products (classical and popular music, dance, film, literature, theater, television fiction, and visual arts) in American, Dutch, French, and German newspapers between 1955 and 2005. Using content analysis, it is first explored to what extent the explosive growth of international cultural traffic in the second half of the twentieth century has been accompanied by increased newspaper coverage of foreign arts and culture in the four countries under study. Second, the article examines the assumption that the degree and direction of international orientation differs among countries according to their size, the centrality of their cultural production or their production in particular cultural fields, and their cultural policy framework. Third, the article qualifies the evolving patterns of dominance in the international orientation of arts journalism in each country, in terms of countries and regions represented in arts and culture coverage

Incidence and prevalence of primary biliary cholangitis in the Netherlands – A nationwide cohort study

Background &amp; Aims: Although primary biliary cholangitis (PBC) is considered a rare disorder, accurate determination of its incidence and prevalence remains challenging due to limited comprehensive population-based registries. We aimed to assess the incidence and prevalence of PBC in the Netherlands over time through the nationwide Dutch PBC Cohort Study (DPCS). Methods: DPCS retrospectively included every identifiable patient with PBC in the Netherlands from 1990 onwards in all 71 Dutch hospitals. Incidence and prevalence were assessed between 2008-2018 by Poisson regression between sex and age groups over time. Results: On the 1st of January 2008, there were 1,458 patients with PBC in the Netherlands. Between 2008-2018, 2,187 individuals were newly diagnosed, 46 were transplanted and 468 died. The yearly incidence of PBC in 2008 was 1.38, increasing to 1.74 per 100,000 persons in 2018. When compared to those aged <45 years, females aged 45-64 years (adjusted incidence rate ratio 4.21, 95% CI 3.76-4.71, p <0.001) and males ≥65 years (adjusted incidence rate ratio 14.41, 95% CI 9.62-21.60, p <0.001) were at the highest risk of being diagnosed with PBC. The male-to-female ratio of patients newly diagnosed with PBC during the study period was 1:14 in those <45 years, 1:10 in patients aged 45-64 years, and 1:4 in those ≥65 years. Point prevalence increased from 11.9 in 2008 to 21.5 per 100,000 persons in 2018. Average annual percent change in this time period was 5.94% (95% CI 5.77-6.15, p <0.05), and was the highest among the population aged ≥65 years (5.69%, 95% CI 5.32-6.36, p <0.001). Conclusions: In this nationwide cohort study, we observed an increase in both the incidence and prevalence of PBC in the Netherlands over the past decade, with marked age and sex differences. Impact and implications:: This nationwide Dutch primary biliary cholangitis (PBC) Cohort Study, including all hospitals in the Netherlands, showed that the incidence and prevalence of PBC have increased over the last decade. The age-dependent PBC incidence rate differed for males (highest risk ≥65 years) and females (highest risk between 45 and 65 years), which may be related to a difference in the timing of exposure to environmental triggers of PBC. The largest increase in PBC prevalence over time was observed in the population aged ≥65 years, which may have implications for the use of second-line therapies. These results therefore indicate that further studies are needed to elaborate on the advantages and disadvantages of add-on therapies in the elderly population