Talaroxanthone, A Novel Xanthone Dimer From The Endophytic Fungus Talaromyces Sp. Associated With Duguetia Stelechantha (diels) R. E. Fries

DgCr22.1b, an endophytic isolate of Talaromyces sp., was collected in the Amazonian Rainforest from the medicinal plant Duguetia stelechantha. From the fractionation of the methanolic mycelial extract, a new xanthone dimer talaroxanthone was isolated. The structure of this new compound was elucidated based on spectroscopic analyses including 2D nuclear magnetic resonance (NMR) experiments. © 2013 Sociedade Brasileira de Química.245880883Liu, F., Cai, X.L., Yang, H., Xia, X.K., Guo, Z.Y., Yuan, J., Li, M.F., Lin, Y.C., (2010) Planta Med., 76, p. 185Dong, Y., Yang, J., Zhang, H., Lin, J., Ren, X., Liu, M., Lu, X., He, J., (2006) J. Nat. Prod., 69, p. 128Dethoup, T., Manoch, L., Kijjoa, A., Pinto, M., Gales, L., Damas, A.M., Silva, A.M.S., Herz, W., (2007) J. Nat. Prod., 70, p. 1200Li, L.Q., Yang, Y.G., Zeng, Y., Zou, C., Zhao, P.J., (2010) Molecules, 15, p. 3993Masters, K.S., Brase, S., (2012) Chem. Rev., 112, p. 3712Cao, S., McMillin, D.W., Tamayo, G., Delmore, J., Mitsiades, C.S., Clardy, J., (2012) J. Nat. Prod., 75, p. 793Krohn, K., Kouam, S.F., Kuigoua, G., Hussain, H., Brandt, S.C., Florke, U., Kurtán, T., Schulz, B., (2009) Chem. Eur. J., 15, p. 12121Isaka, M., Jaturapat, A., Rukseree, K., Danwisetkanjana, K., Tanticharoen, M., Thebtaranonth, Y., (2001) J. Nat. Prod., 64, p. 1015Pornpakakul, S., Liangsakul, J., Ngamrojanavanich, N., Roengsumran, S., Sihanonth, P., Piapukiew, J., Sangvichien, E., Petsom, A., (2006) Arch. Pharmacal Res., 29, p. 140Zhang, W., Krohn, K., Ullah, Z., Flçrke, U., Pescitelli, G., Di Bari, L., Antus, S., Schulz, B., (2008) Chem. Eur. J., 14, p. 4913Koolen, H.H.F., Soares, E.R., Silva, F.M.A., Almeida, R.A., Souza, A.D.L., Medeiros, L.S., Rodrigues Filho, E., Souza, A.Q.L., (2012) Quim. Nova, 35, p. 771Yang, D.M., Takeda, N., Iitaka, Y., Sankawa, U., Shibata, S., (1973) Tetrahedron, 29, p. 519Isaka, M., Palasarn, S., Kocharin, K., Saenboonrueng, S., (2005) J. Nat. Prod., 68, p. 945Franck, B., (1980) The Biosynthesis of the Ergochromes - A Study in Secondary Metabolism, 1. , 1st ed. Academic Press: London, UKAndersen, R., Buchi, G., Kobbe, B., Demain, A.L., (1977) J. Org. Chem., 42, p. 352Kurobane, I., Vining, L.C., McInnes, A.G., (1979) J. Antibiot., 32, p. 1256Steyn, P.S., (1970) Tetrahedron, 26, p. 51Souza, A.D.L., Rodrigues Filho, E., Souza, A.Q.L., Pereira, J.O., Calgarotto, K., Maso, V., Marangoni, S., Silva, S.L., (2008) Toxicon, 51, p. 240Souza, A.Q.L., Souza, A.D.L., Astolfi Filho, S., Pinheiro, M.L.B., Sarquis, M.I.M., Pereira, J.O., (2004) Acta Amazon., 34, p. 18

Chemical Composition And Antimicrobial Activity Of The Essential Oils Of Onychopetalum Amazonicum R.e.fr.

The essential oils from leaves, twigs and trunk bark of Onychopetalum amazonicum R.E. Fr. (Annonaceae), obtained by hydrodistillation, were analysed by GC and GC–MS, and also were evaluated for in vitro antimicrobial activity. Forty-one compounds, which correspond to 75.0–92.2% of the oil components, were identified. Major compounds were sesquiterpenes, including (E)-caryophyllene, caryophyllene oxide, spathulenol, α-gurjunene, allo-aromadendrene and α-epi-cadinol. The oils were evaluated for antimicrobial activities against four bacteria strains and five pathogenic fungi. The oil of the trunk bark exhibited good activity against Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 10538 and Kocuria rhizophila ATCC 9341, with a minimal inhibitory concentration of 62.5 μg/mL. The essential oil composition and the antimicrobial evaluation are reported for the first time for the genus Onychopetalum. © 2016 Informa UK Limited, trading as Taylor & Francis Group.30202356235