The Role of Ivabradine in the Management of Angina Pectoris

Stable angina pectoris affects 2–4 % of the population in Western countries and entails an annual risk of death and nonfatal myocardial infarction of 1–2 % and 3 %, respectively. Heart rate (HR) is linearly related to myocardial oxygen consumption and coronary blood flow, both at rest and during stress. HR reduction is a key target for the prevention of ischemia/angina and is an important mechanism of action of drugs which are recommended as first line therapy for the treatment of angina in clinical guidelines. However, many patients are often unable to tolerate the doses of beta blocker or non-dihydropyridine calcium antagonists required to achieve the desired symptom control. The selective pacemaker current inhibitor ivabradine was developed as a drug for the management of patients with angina pectoris, through its ability to reduce HR specifically. The available data suggest that ivabradine is a well-tolerated and effective anti-anginal agent and it is recommended as a second-line agent for relief of angina in guidelines. However, recent clinical trials of ivabradine have failed to show prognostic benefit and have raised potential concerns about safety. This article will review the available evidence base for the current role of ivabradine in the management of patients with symptomatic angina pectoris in the context of stable coronary artery disease

A photometric and spectroscopic survey of solar twin stars within 50 parsecs of the Sun: I. Atmospheric parameters and color similarity to the Sun

Solar twins and analogs are fundamental in the characterization of the Sun's place in the context of stellar measurements, as they are in understanding how typical the solar properties are in its neighborhood. They are also important for representing sunlight observable in the night sky for diverse photometric and spectroscopic tasks, besides being natural candidates for harboring planetary systems similar to ours and possibly even life-bearing environments. We report a photometric and spectroscopic survey of solar twin stars within 50 pc of the Sun. Hipparcos absolute magnitudes and (B-V)_Tycho colors were used to define a 2 sigma box around the solar values, where 133 stars were considered. Additional stars resembling the solar UBV colors in a broad sense, plus stars present in the lists of Hardorp, were also selected. All objects were ranked by a color-similarity index with respect to the Sun, defined by uvby and BV photometry. Moderately high-resolution, high-S/N spectra were used for a subsample of equatorial-southern stars to derive Teff, log g, and [Fe/H] with average internal errors better than 50 K, 0.20 dex, and 0.08 dex, respectively. Ages and masses were estimated from theoretical HR diagrams. The color-similarity index proved very successful. We identify and rank new excellent solar analogs, which are fit to represent the Sun in the night sky. Some of them are faint enough to be of interest for moderately large telescopes. We also identify two stars with near-UV spectra indistinguishable from the Sun's. We present five new "probable" solar twin stars, besides five new "possible" twins. Masses and ages for the best solar twin candidates lie very close to the solar values, but chromospheric activity levels range somewhat. We propose that the solar twins be emphasized in the ongoing searches for extra-solar planets and SETI searches.Comment: 25 pages, 15 figures, 14 table

Power-law statistics and stellar rotational velocities in the Pleiades

In this paper we will show that, the non-gaussian statistics framework based on the Kaniadakis statistics is more appropriate to fit the observed distributions of projected rotational velocity measurements of stars in the Pleiades open cluster. To this end, we compare the results from the $\kappa$ and $q$-distributions with the Maxwellian.Comment: 13 pages, 3 figure

New Algorithms for Computing a Single Component of the Discrete Fourier Transform

This paper introduces the theory and hardware implementation of two new algorithms for computing a single component of the discrete Fourier transform. In terms of multiplicative complexity, both algorithms are more efficient, in general, than the well known Goertzel Algorithm.Comment: 4 pages, 3 figures, 1 table. In: 10th International Symposium on Communication Theory and Applications, Ambleside, U