Atopic dermatitis: a need to define the disease activity

INTRODUCTION : Atopic dermatitis (AD) is one of the most frequent inflammatory skin diseases characterized by flares and remissions of eczematous lesions and intense itching. Mild disease is the most common severity presentation, nevertheless it is estimated that 20–30% of patients suffer from moderate-to-severe AD. Until recently, there was an unmet need for long-term disease control in these more severe patients. The emergence of new systemic therapies has led to significant clinical improvement for many patients. Therefore, during the long-term management of AD, it is important to properly characterize the severity of the disease in order to allow optimal and individual therapeutic decisions. However, the terminology used needs to be clearly defined. [...

PLACE DES IMMUNOGLOBULINES E DANS LA PEMPHIGOÏDE BULLEUSE

La pemphigoïde bulleuse (PB) est une maladie bulleuse auto-immune fréquente, touchant essentiellement l’adulte de plus de 70 ans. Les autoanticorps impliqués sont essentiellement des immunoglobulines G ciblant les hémidesmosomes de la lame basale et plus spécifiquement BP180 et BP230. Toutefois la présence de lésions urticariennes associées, l’infiltration cutanée par des éosinophiles, l’éosinophilie sanguine et le taux d’IgE élevé chez ces patients supportent l’hypothèse que les immunoglobulines E (IgE) semblent également jouer un rôle. Des IgE anti BP180 ont été mis en évidence chez 40 à 77% (1, 2) des patients atteints de PB. Ces anticorps seraient corrélés à l’activité de la maladie (1). Ils n’agiraient pas directement sur le membrane basale mais se fixeraient sur les mastocytes et les éosinophiles et causeraient leur dégranulation dès la capture de BP180 (3). Ces découvertes récentes ouvrent de nouvelles voies thérapeutiques avec entre autre une place pour l’omalizumab (anticorps monoclonal anti-IgE), remboursé dans le traitement de l’urticaire chronique spontanée résistante aux antihistaminiques (4)

Immunological aspects of chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease characterized by pruritic urticarial wheals and/or swelling, named angioedema. Immunological mechanisms implicated in lesions occurrence are not well-known. A defect in self-tolerance (referred as autoimmunity) is present in a subset of patients. In this prospective work, we have studied some autoimmune markers in a large cohort of patients with CSU. We have also studied the expression of some cytokines and have found that IL-6, IL-1β and IL-24 are present and are possibly involved in CSU lesions development. Cytokines are molecules implicated in communication between cells and more particularly immune cells. Since cytokine blocking therapeutics are effective in some inflammatory and autoimmune diseases, identifying cytokines implicated in CSU is a major therapeutic challenge in this disease.(MED - Sciences médicales) -- UCL, 201

Urticaire chronique: “pièges et erreurs”

No abstract availabl

Prise en charge et traitement de l’urticaire chronique: éclairage immunologique

No abstract availabl

Re-emergence of allergic contact dermatitis from chlorphenesin.

Only a few cases of allergic contact dermatitis (ACD) from chlorphenesin have been reported and since 2015 no new cases have been published. We describe two additional cases of ACD from this preservative in cosmetics observed during late 2021. [...

Adverse cutaneous reaction to diabetic glucose sensors and insulin pumps: Irritant contact dermatitis or allergic contact dermatitis?

BACKGROUND: Adverse cutaneous reactions to diabetes medical devices (glucose sensors and insulin pumps) are described, notably allergic contact dermatitis (ACD) with isobornyl acrylate (IBOA) and N,N dimethylacrylamide (DMAA) as the main allergen. OBJECTIVES: To determine if all cases of adverse cutaneous reactions observed with diabetes medical devices (ie FreeStyle Libre, Enlite sensors or insulin pumps), referred to our department with suspected allergies are confirmed as ACD. PATIENTS AND METHODS: Fifty-two patients who presented skin reactions to diabetes medical devices were patch tested with the European baseline series, a plastic and glues series, a (meth) acrylates series, a piece of the adhesive part of the device, as well as IBOA 0.1% and DMAA 0.1% pet. RESULTS: Seventeen patients had no positive reaction to IBOA nor to the adhesive part of the device; 11 of these also tested with DMAA with negative result. No other relevant allergen was identified. CONCLUSION: Some cutaneous reactions, otherwise very similar to those of patients sensitized to IBOA, can be explained either by the presence of an untested allergen not yet discovered, or by irritant contact dermatitis. Therefore, European legislation on the full labelling of ingredients by manufacturers, in order to facilitate the identification of allergens and irritants, is imperative

A rare case of adrenergic urticaria in a child.

DEAR EDITOR, Adrenergic urticaria (AdrU) is a rare sub-type of chronic urticaria characterized by pruritic erythematous wheals surrounded by a pale halo of vasoconstriction. Flares can be associated with clinical features such as wheezing, dyspnoea, palpitations and malaise. [...

Chronic spontaneous urticaria following COVID-19 vaccination.

INTRODUCTION : We report a case series of 8 patients who developed chronic spontaneous urticaria (CSU) following vaccination against SARS-CoV-2 infection [...]