Fatores associados ao tipo de parto na rede pública de Patos de Minas – MG / Factors associated with the type of delivery in the public network of patos de Minas – MG

Introdução: A taxa de cesarianas em Patos de Minas, Minas Gerais, encontra-se bem acima dos 10% preconizado pela Organização Mundial da Saúde (OMS). Objetivo: Estabelecer a relação entre os fatores socioeconômicos e gestacionais que influenciam na escolha do tipo de parto. Metodologia: Trata-se de uma pesquisa descritiva, do tipo transversal com enfoque quantitativo. Os dados foram obtidos do SINASC entre os anos de 2010 e 2016. Para avaliar a significância dos dados foram realizados os testes T e Qui-quadrado. Resultados: O número de partos foi de 21.953, sendo 38,51% vaginais e  61,41% cesáreos, com uma média de 1208 vaginais e 1926 cesáreos. Discussão: Através da análise das variáveis que influenciam no tipo de parto, foi possível inferir que a escolha do parto cesáreo está vinculada a estabilidade socioeconômica da gestante. Conclusão: Diante desses resultados é necessário esforço para que a cesárea só seja realizada quando houver indicação médica. 

Prevalência e conhecimento dos fatores de risco das principais infecções sexualmente transmissíveis no Brasil

Introdução: As infecções sexualmente transmissíveis (IST’s) fazem parte de uma das cinco causas mais frequentes da busca por serviços de saúde em países em desenvolvimento. No Brasil, cerca de 12 milhões de casos de ISTs ocorrem anualmente e diversos fatores contribuem para esta alta prevalência, principalmente o comportamento de risco dos indivíduos. Objetivo: O objetivo deste estudo foi avaliar a incidência da sífilis, HIV e das hepatites B e C, assim como o comportamento de risco e presença de sintomas para tais doenças. Metodologia: Os dados foram obtidos por meio de um questionário com perguntas objetivas disponibilizado em uma plataforma online. Resultados: Um total de 147 participantes responderam ao questionário. Destes, 8 (5,4%) dos entrevistados afirmaram ter sido diagnosticado com alguma IST, sendo que dois (1,4%) foram diagnosticados com sífilis, um (0,7%) com HIV, um (0,7%) teve diagnóstico de hepatite B e cinco (3,4%) foram diagnosticados com outras doenças. Conclusões: Os resultados do presente estudo demonstraram um alto índice de práticas de risco que podem contribuir para a disseminação dessas doenças

A prescrição farmacêutica: uma análise do conhecimento dos profissionais farmacêuticos da cidade de Barra do Garças-MT / Pharmaceutical prescription: an analysis of the knowledge of pharmaceutical professionals in the city of Barra do Garças-MT

O objetivo desta pesquisa foi analisar a percepção dos farmacêuticos de Barra do Garças-MT em relação à prescrição farmacêutica. Verificar se há execução de atenção farmacêutica pelos Farmacêuticos locais; e averiguar o conhecimento das atribuições clinicas dos Farmacêuticos. Trata-se de um estudo observacional analítico de corte transversal, cuja essência está na observação do conhecimento dos Farmacêuticos atuantes. A pesquisa foi realizada no município de Barra do Garças, localizado na Região Centro-Oeste, no estado de Mato Grosso. A amostra contempla farmacêuticos atuantes nas farmácias e drogarias, composta por 32 estabelecimentos, no período de 15 de agosto a 15 de setembro de 2020. Através dos dados coletados na presente pesquisa, foi possivel observar que os profissionais farmacêuticos acreditam que a prescrição farmacêutica foi um ganho para a profissão e grande parte dos mesmos acredita que a prescrição trouxe benefícios. Alguns pontos negativos também foram levantados, como muitos farmacêuticos na duvidas ao invés de procurar informações com outros profissionais da saúde, ainda prefere atender o paciente. Diante de tantos questionamentos levantados no presente estudo, ressalta-se a necessidade da transformação das farmácias em verdadeiros estabelecimentos de saúde

Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe

Purpose: In the accompanying article, “Analysis of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions. Methods: We provide data on the legalities of third-party assisted reproductive technologies and other family-building options in the 28 oncofertility-practicing countries surveyed. Results: We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms. Conclusion: Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients

Analysis of possible pathways on the mechanism of action of minocycline and doxycycline against strains of Candida spp. resistant to fluconazole

Species of the genus Candida, characterized as commensals of the human microbiota, are opportunistic pathogens capable of generating various types of infections with high associated costs. Considering the limited pharmacological arsenal and the emergence of antifungal-resistant strains, the repositioning of drugs is a strategy used to search for new therapeutic alternatives, in which minocycline and doxycycline have been evaluated as potential candidates. Thus, the objective was to evaluate the in vitro antifungal activity of two tetracyclines, minocycline and doxycycline, and their possible mechanism of action against fluconazole-resistant strains of Candida spp. The sensitivity test for antimicrobials was performed using the broth microdilution technique, and the pharmacological interaction with fluconazole was also analysed using the checkerboard method. To analyse the possible mechanisms of action, flow cytometry assays were performed. The minimum inhibitory concentration obtained was 4-427 µg ml-1 for minocycline and 128-512 µg ml-1 for doxycycline, and mostly indifferent and additive interactions with fluconazole were observed. These tetracyclines were found to promote cellular alterations that generated death by apoptosis, with concentration-dependent reactive oxygen species production and reduced cell viability. Therefore, minocycline and doxycycline present themselves as promising study molecules against Candida spp.This study was supported by grants and fellowships from the research support agencies CNPq, CAPES and FUNCAP/Ceará.Peer reviewe

Survey of third-party parenting options associated with fertility preservation available to patients with cancer around the globe

bstract PURPOSE In the accompanying article, “Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions. METHODS We provide data on the legalities of third-party assisted reproductive technologies and other familybuilding options in the 28 oncofertility-practicing countries surveyed. RESULTS We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms. CONCLUSION Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO

Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE