27 research outputs found

    Les frontières de la Cité des Andes

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    Dain Philippe. Les frontières de la Cité des Andes. In: Annales de Bretagne. Tome 75, numéro 1, 1968. pp. 175-201

    Les Mythographes du Vatican

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    Dain Philippe. Les Mythographes du Vatican . In: Autour de Lactance : hommages à Pierre Monat. Besançon : Institut des Sciences et Techniques de l'Antiquité, 2003. pp. 225-234. (Collection « ISTA », 903

    Le monnayage d'or des Andecavi

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    La découverte, en 1966, d'un trésor monétaire gaulois sur les marches de la cité des Andes a permis d'apporter une solution à l'une des dernières énigmes du monnayage armoricain. Les travaux du Dr Colbert de Beaulieu avaient montré l'appartenance à chacune des cités de la Bretagne bretonnante d'un monnayage particulier. Il restait à élucider le problème des cités marginales du sud, les Namnetes et les Andes. Le monnayage étant le témoignage concret de la puissance économique d'une cité, il ne fait pas de doute qu'à ce point de vue les Namnetes, maîtres des débouchés de la Loire, étaient largement supérieurs aux Andes, cité seulement riveraine. Jusqu'à présent, il n'avait été porté attention qu'à un seul type, plus largement répandu sur le territoire namnète, le type dit « au génie hippophore », présentant au revers un génie à mi-corps hissant un cheval androcéphale, et qui avait été attribué soit aux seuls Namnetes, soit aux deux cités ensemble. L'existence dans le trésor de Denée, à côté de nombreux statères à l'hippophore, d'un certain nombre de pièces d'un type jusqu'ici attribué aux Osismii a relancé le problème. L'étude, tant des cartes de répartition que des types monétaires, par la méthode dite des homotypies de contiguïté, nous a conduit à attribuer aux Namnetes le type au génie hippophore et aux Andes le type jusqu'ici accordé aux Osismii.Dain Philippe. Le monnayage d'or des Andecavi. In: Revue des Études Anciennes. Tome 73, 1971, n°1-2. pp. 80-123

    Giancarlo Susini, Ricerche sulla battaglia del Trasimeno, Estratto dall'Annuario XI 1956-1960 dell'Accademia Etrusca di Cortona

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    Dain Philippe. Giancarlo Susini, Ricerche sulla battaglia del Trasimeno, Estratto dall'Annuario XI 1956-1960 dell'Accademia Etrusca di Cortona. In: Bulletin de l'Association Guillaume Budé, n°1, mars 1965. p. 131

    Les Mythographes du Vatican

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    Dain Philippe. Les Mythographes du Vatican . In: Autour de Lactance : hommages à Pierre Monat. Besançon : Institut des Sciences et Techniques de l'Antiquité, 2003. pp. 225-234. (Collection « ISTA », 903

    Mythographes du Vatican I

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    Dain Philippe. Mythographes du Vatican I. Traduction et commentaire. Besançon : Université de Franche-Comté, 1995. 274 p. (Annales littéraires de l'Université de Besançon, 579

    Mythographe du Vatican III

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    Dain Philippe. Mythographe du Vatican III. Traduction et commentaire. Besançon : Institut des Sciences et Techniques de l'Antiquité, 2005. 284 p. (Collection « ISTA », 854

    Mythographe du Vatican II. Traduction et commentaire

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    , . Mythographe du Vatican II. Traduction et commentaire. Besançon : Institut des Sciences et Techniques de l'Antiquité, 2000. 340 p. (Collection « ISTA », 719

    Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: Epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-study

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    Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm) profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS), are scarce. Objectives of this study were to investigate DNAm signatures associated with in utero tobacco smoke exposure beyond the 12th week of gestation in whole blood of children at age 5.5 years, to replicate previous findings in young European and American children and to assess their biological role by exploring databases and enrichment analysis. DNA methylation was measured in blood of 366 children of the multicentre European Childhood Obesity Project Study using the Illumina Infinium HM450 Beadchip (HM450K). An EWAS was conducted using linear regression of methylation values at each CpG site against in utero smoke exposure, adjusted for study characteristics, biological and technical effects. Methylation levels at five HM450K probes in MYO1G (cg12803068, cg22132788, cg19089201), CNTNAP2 (cg25949550), and FRMD4A (cg11813497) showed differential methylation that reached epigenome-wide significance according to the false-discovery-rate (FDR) criteria (q-value<0.05). Whereas cg25949550 showed decreased methylation (-2% DNAm β-value), increased methylation was observed for the other probes (9%: cg12803068; 5%: cg22132788; 4%: cg19089201 and 4%: cg11813497) in exposed relative to non-exposed subjects. This study thus replicates previous findings in children ages 3 to 5, 7 and 17 and confirms the postnatal stability of MYO1G, CNTNAP2 and FRMD4A differential methylation. The role of this differential methylation in mediating childhood phenotypes, previously associated with maternal smoking, requires further investigation.0SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Endocrine and Metabolic Biomarkers Predicting Early Childhood Obesity Risk

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    There is growing evidence of long-term effects of early dietary intervention in infancy on later obesity risk. Many studies showed reduced risk of obesity with breastfeeding in infancy, which could be related to the reduced protein intake with human milk compared to infant formula. In a randomized controlled trial (Childhood Obesity Project), we were able to show that infant formula with reduced protein content results in lower BMI both at 2 and 6 years. These effects seem to be mediated mainly by branched-chain amino acids which stimulate the insulin-like growth factor (IGF)-1 axis and insulin release. In this trial, we also showed an influence of high-protein diet on larger kidney size, which seems to be partly explained by a significant effect of free IGF-1 on kidney volume. The IGF-1 axis was shown to regulate early growth, adipose tissue differentiation and early adipogenesis in animals and in humans. Leptin and adiponectin can also be regarded as important endocrine regulators of obesity. These markers were tested in observational studies. Leptin seems to be closely correlated with BMI but changes in adiponectin require further exploration. Still, there is a lack of good data or some results are contradictory to indicate the role of either leptin or adiponectin in infancy for determining later obesity risk.0SCOPUS: ar.kinfo:eu-repo/semantics/publishe
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