1 research outputs found
Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use
of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because
of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is
associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications
following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T
lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection