2,444 research outputs found
On the Photometric Accuracy of RHESSI Imaging and Spectrosocopy
We compare the photometric accuracy of spectra and images in flares observed
with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI)}spacecraft. We
test the accuracy of the photometry by comparing the photon fluxes obtained in
different energy ranges from the spectral-fitting software SPEX with those
fluxes contained in the images reconstructed with the Clean, MEM, MEM-Vis,
Pixon, and Forward-fit algorithms. We quantify also the background fluxes, the
fidelity of source geometries, and spatial spectra reconstructed with the five
image reconstruction algorithms. We investigate the effects of grid selection,
pixel size, field-of-view, and time intervals on the quality of image
reconstruction. The detailed parameters and statistics are provided in an
accompanying CD-ROM and web page. We find that Forward-fit, Pixon, and Clean
have a robust convergence behavior and a photometric accuracy in the order of a
few percents, while MEM does not converge optimally for large degrees of
freedom (for large field-of-views and/or small pixel sizes), and MEM-Vis
suffers in the case of time-variable sources. This comparative study documents
the current status of the RHESSI spectral and imaging software, one year after
launch.Comment: 2 Figures, full version on
http://www.lmsal.com/~aschwand/eprints/2003_photo/index.htm
General practitioner perception of prostate-specific antigen testing has improved, but more awareness of prostate cancer risk in younger patients is still awaited.
BACKGROUND: In 2006, a county-wide survey of general practitioners (GPs) in the United Kingdom (UK) identified a reluctance to refer younger men with abnormal prostate specific antigen (PSA) levels. Younger men have the most to gain from early-detection of prostate cancer (PCa), which remains a national government priority in the UK and around the world. We sought to assess changes in perception of abnormal PSA-values amongst UK GPs over the past 10 years. MATERIALS AND METHODS: A total of 500 self-administered paper questionnaires were distributed to individually named GPs. One hundred and forty two responded (28.4%), representing a patient population of ∼600,000. A series of visual analogue questions assessed referral thresholds and understanding of risk factors related to the development of PCa. RESULTS: GPs with a median of 23-years experience responded. Although mean PSA threshold for referral to urology did fall between 2006 and 2016 in both the 45-year (5.42 ng/mL vs. 4.61 ng/mL P = 0.0003) and 55-year (5.81 ng/mL vs. 5.30 ng/mL P = 0.0164) age groups, the median referral values were unchanged. Significantly, referral thresholds quoted for younger men (<65 years) were considerably higher than recommended UK maximum PSA-levels. Using case-based scenarios, practitioners appeared more likely to refer older men with abnormal PSA values, with GPs reporting an average 56.2% likelihood of referring an asymptomatic 55-year-old with elevated age-adjusted PSA of 4.6 ng/mL. A total of 95.1% recognised a family history of PCa to be a potential risk factor but other at-risk categories were not so clearly understood. CONCLUSION: Awareness of abnormal PSA values in UK primary care is improving, but continues to lag behind the evidence. Strategies to disseminate knowledge of maximum PSA-values to GPs should focus especially on those for younger patients
(Re)constructing Dimensions
Compactifying a higher-dimensional theory defined in R^{1,3+n} on an
n-dimensional manifold {\cal M} results in a spectrum of four-dimensional
(bosonic) fields with masses m^2_i = \lambda_i, where - \lambda_i are the
eigenvalues of the Laplacian on the compact manifold. The question we address
in this paper is the inverse: given the masses of the Kaluza-Klein fields in
four dimensions, what can we say about the size and shape (i.e. the topology
and the metric) of the compact manifold? We present some examples of
isospectral manifolds (i.e., different manifolds which give rise to the same
Kaluza-Klein mass spectrum). Some of these examples are Ricci-flat, complex and
K\"{a}hler and so they are isospectral backgrounds for string theory. Utilizing
results from finite spectral geometry, we also discuss the accuracy of
reconstructing the properties of the compact manifold (e.g., its dimension,
volume, and curvature etc) from measuring the masses of only a finite number of
Kaluza-Klein modes.Comment: 23 pages, 3 figures, 2 references adde
New Lower Bounds on the Self-Avoiding-Walk Connective Constant
We give an elementary new method for obtaining rigorous lower bounds on the
connective constant for self-avoiding walks on the hypercubic lattice .
The method is based on loop erasure and restoration, and does not require exact
enumeration data. Our bounds are best for high , and in fact agree with the
first four terms of the expansion for the connective constant. The bounds
are the best to date for dimensions , but do not produce good results
in two dimensions. For , respectively, our lower bound is within
2.4\%, 0.43\%, 0.12\%, 0.044\% of the value estimated by series extrapolation.Comment: 35 pages, 388480 bytes Postscript, NYU-TH-93/02/0
Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynamic pattern of glucocorticoid receptor (GR) binding at ~3,000 genomic sites in liver at the pulse peak, subsequently not found during the pulse nadir. In contrast, constant corticosterone replacement induced prolonged binding at the majority of these sites. Additionally, each pattern further induced markedly different transcriptional responses. During pulsatile treatment, intragenic occupancy by active RNA polymerase II exhibited pulsatile dynamics with transient changes in enrichment, either decreased or increased depending on the gene, which mostly returned to baseline during the inter-pulse interval. In contrast, constant corticosterone exposure induced prolonged effects on RNA polymerase II occupancy at the majority of gene targets, thus acting as a sustained regulatory signal for both transactivation and repression of glucocorticoid target genes. The nett effect of these differences were consequently seen in the liver transcriptome as RNA-seq analysis indicated that despite the same overall amount of corticosterone infused, twice the number of transcripts were regulated by constant corticosterone infusion, when compared to pulsatile. Target genes that were found to be differentially regulated in a pattern-dependent manner were enriched in functional pathways including carbohydrate, cholesterol, glucose and fat metabolism as well as inflammation, suggesting a functional role for dysregulated glucocorticoid rhythms in the development of metabolic dysfunction
Observation of Hadronic W Decays in t-tbar Events with the Collider Detector at Fermilab
We observe hadronic W decays in t-tbar -> W (-> l nu) + >= 4 jet events using
a 109 pb-1 data sample of p-pbar collisions at sqrt{s} = 1.8 TeV collected with
the Collider Detector at Fermilab (CDF). A peak in the dijet invariant mass
distribution is obtained that is consistent with W decay and inconsistent with
the background prediction by 3.3 standard deviations. From this peak we measure
the W mass to be 77.2 +- 4.6 (stat+syst) GeV/c^2. This result demonstrates the
presence of two W bosons in t-tbar candidates in the W (-> l nu) + >= 4 jet
channel.Comment: 20 pages, 4 figures, submitted to PR
Search for Chargino-Neutralino Associated Production at the Fermilab Tevatron Collider
We have searched in collisions at = 1.8 TeV for events
with three charged leptons and missing transverse energy. In the Minimal
Supersymmetric Standard Model, we expect trilepton events from
chargino-neutralino (\chione \chitwo) pair production, with subsequent decay
into leptons. We observe no candidate , ,
or events in 106 pb integrated
luminosity. We present limits on the sum of the branching ratios times cross
section for the four channels: \sigma_{\chione\chitwo}\cdot
BR(\chione\chitwo\to 3\ell+X) 81.5 \mgev\sp and
M_\chitwo > 82.2 \mgev\sp for , ~\mgev\sp and
M_\squark= M_\gluino.Comment: 9 pages and 3 figure
Search for charged Higgs decays of the top quark using hadronic tau decays
We present the result of a search for charged Higgs decays of the top quark,
produced in collisions at 1.8 TeV. When the charged
Higgs is heavy and decays to a tau lepton, which subsequently decays
hadronically, the resulting events have a unique signature: large missing
transverse energy and the low-charged-multiplicity tau. Data collected in the
period 1992-1993 at the Collider Detector at Fermilab, corresponding to
18.70.7~pb, exclude new regions of combined top quark and charged
Higgs mass, in extensions to the standard model with two Higgs doublets.Comment: uuencoded, gzipped tar file of LaTeX and 6 Postscript figures; 11 pp;
submitted to Phys. Rev.
Inclusive jet cross section in collisions at TeV
The inclusive jet differential cross section has been measured for jet
transverse energies, , from 15 to 440 GeV, in the pseudorapidity region
0.10.7. The results are based on 19.5 pb of data
collected by the CDF collaboration at the Fermilab Tevatron collider. The data
are compared with QCD predictions for various sets of parton distribution
functions. The cross section for jets with GeV is significantly
higher than current predictions based on O() perturbative QCD
calculations. Various possible explanations for the high- excess are
discussed.Comment: 8 pages with 2 eps uu-encoded figures Submitted to Physical Review
Letter
Measurement of the lepton charge asymmetry in W-boson decays produced in p-pbar collisions
We describe a measurement of the charge asymmetry of leptons from W boson
decays in the rapidity range 0 enu, munu events from
110+/-7 pb^{-1}of data collected by the CDF detector during 1992-95. The
asymmetry data constrain the ratio of d and u quark momentum distributions in
the proton over the x range of 0.006 to 0.34 at Q2 \approx M_W^2. The asymmetry
predictions that use parton distribution functions obtained from previously
published CDF data in the central rapidity region (0.0<|y_l|<1.1) do not agree
with the new data in the large rapidity region (|y_l|>1.1).Comment: 13 pages, 3 tables, 1 figur
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