1 research outputs found
Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
BackgroundClinical characteristics and outcomes of takotsubo syndrome (TTS)
patients with malignancy have not been fully elucidated. This study
sought to explore differences in clinical characteristics and to
investigate shortâ and longâterm outcomes in TTS patients with or without malignancy.Methods and ResultsTTS patients were enrolled from the International Takotsubo Registry. The TTS
cohort was divided into patients with and without malignancy to
investigate differences in clinical characteristics and to assess shortâ
and longâterm mortality. A subanalysis was performed comparing
longâterm mortality between a subset of TTS
patients with or without malignancy and acute coronary syndrome (ACS)
patients with or without malignancy. Malignancy was observed in 16.6% of
1604 TTS
patients. Patients with malignancy were older and more likely to have
physical triggers, but less likely to have emotional triggers compared
with those without malignancy. Longâterm mortality was higher in
patients with malignancy (PP=0.17). In a subanalysis, longâterm mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of longâterm mortality.ConclusionsA substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients.</p