Potential Anti-Apoptotic Impacts and Telomerase Activity of Royal Jelly on Different Tissues of Rats

ackground and Aim: Royal jelly (RJ) has a broad range of pharmaceutical activities, including antioxidant, anti-aging, anti-tumor, and anti-apoptotic. The current study aimed to investigate RJ impacts on cell survival by measuring the amount of telomerase enzyme, protein BCL2, and BAX in different tissues of rats. Methods: In this study, male Wistar rats (n=21) were randomly divided into 3 groups; Group 1 was the control group. Group 2 and group 3 were treated with royal jelly at a concentration of 150 mg/kg and 300 mg/kg for 30 days, respectively. The contents of Bax, BCL-2, and telomerase in the tissues Brain, Liver, Kidney, and lymphocytes were measured using the ELISA method. Results: Telomerase increased in all the tissues involved in both treatment groups compared to the control group; however, the changes were not statistically significant. Although BAX and BCL-2 proteins showed irregular patterns, the ratio of BAX/BCL-2 declined in almost all the studied tissues with a significant decline in the rats’ liver and kidney treated with RJ at the dose of 300 mg/kg and in the lymphocytes of the group administered 150 mg/kg of RJ. Conclusion: RJ appears to have potential anti-apoptotic effects on the rats’ tissues studied via regulating the levels of BAX, BCL-2, and telomerase proteins. Regarding telomerase, its levels increased in a dose-dependent manner in all involved tissues. Concerning the ratio of BAX/BCL-2, it is sensible to conclude that RJ tends to positively impact the cell survival rate at the dose of 300 mg/kg in the brain, Liver, and Kidney. Nonetheless, this ratio decreased more significantly at the dose of 150 mg/kg in lymphocytes, showing more potential to survive brain cells in this concentration. *Corresponding Author: Seyed-Hosein Abtahi-Eivary; Email: [email protected]; ORCID ID:0000-0001-5807-8933 Please cite this article as: Khani-Eshratabadi M, Talebpour A, Bagherzadeh A, Mehranfar P, Motallebzadeh Khanmiri J, Ghorbani M, Abtahi-Eivary SH. Potential Anti-Apoptotic Impacts and Telomerase Activity of Royal Jelly on Different Tissues of Rats. Arch Med Lab Sci. 2022;8:1-10 (e3). https://doi.org/10.22037/amls.v8.3653

The effect of supply chain quality management and innovation performance on the operational performance of businesses operating in the food industry of Golestan province

As an important dimension of company performance, the impact of supply chain quality management (SCQM) on innovation performance has not been studied in internal studies. In addition, internal research into the capabilities of SCQM, a key driver for SCQM, has been very limited. To fill this research gap, this paper examines how SCQM capabilities and SCQM performance can influence firm innovation and operational performance, and how they interact with each other. For this purpose, the information of managers and experts active in the food industry in Golestan province was collected and analyzed through a questionnaire. Research findings show that SCQM practices have a positive effect on SCQM capabilities. Another result is that SCQM methods do not have a positive effect on the operational performance of food industries in Golestan province. This finding is significantly different from some previous studies. We also found that SCQM capabilities do not have a positive effect on innovation performance

Structural modeling based on supply chain management in relation to total quality management, maintenance and comprehensive productivity, learning organization and operational performance

The aim of this study was to investigate the relationship between comprehensive productive maintenance, TQM, supply chain management, learning organization characteristics and operational performance. In order to conduct research operations, the conceptual framework of the research was first presented by studying the theoretical foundations. In the next stage, by compiling and distributing a questionnaire among 180 people from the statistical population of the research consisting of senior, middle and operational managers aware of the subject under study, export companies of Golestan province were distributed randomly, the information needed to test research hypotheses was collected. Finally, 146 completed return questionnaires were covered by the structural equation modeling technique based on the partial least squares method. The results obtained based on this technique showed that the maintenance and repair of comprehensive productivity has a positive effect on total quality management, while the maintenance and repair of comprehensive productivity alone could not achieve an acceptable result to achieve operational performance and requires comprehensive quality management. . Another result obtained indicates the positive effect of total quality management and supply chain management and the mediating role of supply chain management in achieving operational performance between the two variables of total quality management and operational performance. In addition to these results, it was found that total quality management has a positive effect on the learning organization and the learning organization has an important role between total quality management and operational performance of export companies in Golestan province

Potential Use of Umbilical Cord Mesenchymal Stem Cells for Improving Patients with COVID-19: A Review

The SARS-CoV-2 virus is a member of the coronavirus family that caused the COVID-19 respiratory disease epidemic in China before the global pandemic of the disease in late 2019. The virus's genome is of 79% similarity to that of the SARS-CoV virus, using the ACE2 receptor to enter its target cells. The most common symptoms of this disease include fever, cough, pulmonary involvement, and sometimes gastrointestinal symptoms. A decline in both the number and function of lymphocytes and a severe increase in leukocyte inflammatory activity are among the most obvious immunological complications of this disease. If the immune system response to the virus is inadequate, the disease can become acute. Immune cells activity leads to a sharp increase in the number of blood cytokines, causing "cytokine storm," which in turn can cause systematic damages to the heart, lungs, and kidneys, and ultimately may lead to death. Mesenchymal stem cell therapy offers a promising approach to reducing the destructive impacts of infection in patients with COVID-19. Mesenchymal stem cells can secrete immune-modulating factors that suppress cytokine storms. Furthermore, the role of mesenchymal stem cells in preventing cell death and inhibiting tissue fibrosis has been well demonstrated. This review shows available clinical trials that have tapped into the therapeutic potential of the umbilical cord mesenchymal stem cells in patients with COVID-19. *Corresponding Author: Seyed Hadi Mousavi; Email: [email protected]; ORCID iD: 0000-0002-0163-5839 Please cite this article as: Motallebzadeh Khanmiri J, Khani-Eshratabadi M, Nasirzadeh A, Nematzade M, Talebpour M, Mousavi H. Potential Use of Umbilical Cord Mesenchymal Stem Cells for the Improving Patients with COVID-19. Arch Med Lab Sci. 2021;7:1-12 (e20). https://doi.org/10.22037/amls.v7.3537

An ultra-thin absorber in microwave range: 50 GHz band-width, absorption over 80 %

An ultra-thin microwave absorber with a 34 GHz bandwidth more than 90% absorption in the frequency range of 33.5 GHz - 67.5 GHz, and 50 GHz bandwidth, more than 80 % absorption is proposed. The functionality of the device was analyzed using an equivalent circuit model (ECM) by exploiting the impedance matching concept in the transmission line theory. By changing the chemical potential of the graphene, following manipulating characteristics of the graphene surface conductivity, can achieve several absorption responses in wideband range frequencies. Additionally, the proposed absorption is stable in a wide range of incident angles. These advantages make the proposed absorption attractive for several applications such as optical sensors and detectors

Fully active frequency compensation analysis on multi-stages CMOS amplifier

An enhanced three-stage CMOS transconductance amplifier attached to a novel frequency compensation network is proposed. Two differential stages are attached with Miller capacitors and the Miller effect is boosted accordingly. In this way, four negative loops intensify the Miller effect virtually. The structure is designed at the transistor level using 0.18 μm CMOS library and the SPICE simulator while a symbolical transfer function is extracted and analyzed to obtain circuit dynamics. Leveraging both concept and method, the proposed amplifier shows unconditional stability with acceptable accuracy regarding the symbolic description and simulation results. Ample sensitivity analysis is also provided to show the reliability of the amplifier. By simulation responses, the presented circuit expresses competitive merits against previous works. Simulation results show 120 dB as DC gain, 18 MHz as, GBW, and 54º as phase margin while the simulated amplifier consumes only 345μW

Metamaterial modeling in circuit level for THz wave manipulation

Leveraging both method and concept a two-layer THz absorber based on periodic arrays of graphene rings is proposed. The design methodology based on the equivalent circuit model is developed for the proposed absorber. The device is described as an impedance and also simulated by the FEM full-wave method to verify the circuit model accuracy. According to the simulation results, the proposed THz absorber can show perfect absorption from 0.5 THz to 3.5 THz while adjustability capability is obtained for different chemical potentials. Additionally, the sensitivity against geometrical parameters and different incident angels is investigated. Based on the provided results and the simplicity of the structure, the proposed absorber is an ideal candidate for several applications ranging from security to medical imaging

Single Miller frequency compensation: Three stage CMOS

A simple and efficient frequency compensation network is exploited for a three-stage amplifier. Single Miller capacitor at the output of a differential stage forms compensation network. This configuration benefits from less dependency to compensation capacitor since only one and small value capacitor is used. This stems from the fact that the differential block intensifies Miller effect virtually by multiplying its gain value to capacitor value. The structure is modeled symbolically with exclusive formulation for involved dynamics. Also, circuit implementation is performed via 0.18μmCMOS technology. Both theoretical and simulation results are compatible with negligible error. According to the simulation results, proposed three stage amplifiers in this work show 135 dB, 7.5 MHz and 85º as DC gain, GBW and PM respectively

Improving signal isolation in hybrid RF duplexer utilizing a band-pass filter

This study deals with a passive RF duplexer integrated with a two-notch band. To design the model, a band-pass filter is considered. Using micro-strip technology, the RF duplexer substation is simulated. It is a rectangular in parallel coupling with frequency bands of 1 and 5 GHz while existing three ports. Moreover, to enhance the impedance coefficient and decrease the admittance, the method of complementary paired resonators is taken into account. Furthermore, scattering parameters were used by the step impedance method to make an integrated monolayer substrate from signal branching in duplex mode. Thus, the band-pass filter making the frequency cut-off bands allows designing GSM-4G radars. The low cut-off microwave band is included in these bands at the 77 MHz central frequency and the second cut-off band for GSM-4G radars at the 437 MHz central frequency. The duplexer has the total dimensions of 14 mm × 99 mm and the presented RF duplexer is simulated in CST

Switchable THz wave absorber based on disks and its complement graphene surfaces

A new geometrical vision for a graphene-based THz wave absorber is investigated in this work. A high-performance THz absorber is proposed to exploit complementary conventional periodic arrays of graphene disks. The equivalent circuit model is modified to take account of the complement pattern. The absorber works in two different operational modes based on chemical potential values. One mode shows absorption around 1 THz while the other one expresses perfect absorption at 6 THz and 9 THz. Such a considerable shifting ability via gate stimulations makes the proposed absorber an ideal block for reconfigurable metasurface. The comparison between the circuit model and full-wave simulation verifies an excellent match while ample sensitivity analysis are reported to show the reliability of the proposed switchable THz absorber