Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma

Abstract BACKGROUND: This retrospective study aimed to determine how often a perimetric examination should be carried out in order to identify visual field (VF) changes in patients with relatively early manifestation glaucoma. MATERIALS AND METHODS: Patients included had a relatively recent manifestation of primary open-angle glaucoma. Patients with a minimum follow-up of 5 years and a minimum of seven VF tests were included. Statistical analysis was performed to verify the trend of variations in mean defect (MD) over time (PeriData). The results were subjected to a t-test for a comparative analysis of progression of VF changes over time. The annual rate of progression provided by PeriData considering all the VFs analyzed was compared with that obtained on half of the VF examinations during the same follow-up period. An analysis of the MD trend over time was also carried out in relationship to the number of VF tests done and by dividing the sample into a high-frequency group (more than eight VFs) and a low-frequency group (fewer than eight VFs) in the follow-up period. RESULTS: A total of 96 eyes of 96 patients were included, and overall 846 VFs were examined. The paired t-test performed comparing the MD index of all the VFs against half of them did not show statistical significance (P=0.537). The high-frequency group comprised 39 eyes (average VF 11.05±1.91, average time interval 0.76 years) while the low-frequency group comprised 57 eyes (average VF 6.95±0.6, average time interval 1.21 years). The analysis of the MD trend in the high-frequency patients showed significance (P=0.017); the low-frequency group did not show statistical significance (P=0.08). CONCLUSION: The number of VFs in a determined time interval was not significant. However, a greater frequency of tests provides a predictive evaluation of the rate of progression of early manifestation open-angle glaucoma

"Iridoplasia Yag-laser nel glaucoma angolare. Test della midriasi e variazioni di profondità della camera anteriore". Relazione al Congresso Giornate Mediterranee di Oftalmologia, Roma,8-10 Aprile 1988. Bollettino di Oculistica Anno 68- N.3 : 467-472 . 1989 Ed Cappelli BO ISSN 0006-677X

"Iridoplasia Yag-laser nel glaucoma angolare. Test della midriasi e variazioni di profondità della camera anteriore"

Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma

Andrea Perdicchi,1 Solmaz Abdolrahimzadeh,2 Alessandro Cutini,1 Angela Ciarnella,1 Gian Luca Scuderi1 1Ophthalmology Unit, Facoltà Medicina e Psicologia, Ospedale Sant’Andrea, 2Ophthalmology Unit, DAI Testa/Collo Policlinico Umberto I, Sapienza University of Rome, Rome, Italy Background: This retrospective study aimed to determine how often a perimetric examination should be carried out in order to identify visual field (VF) changes in patients with relatively early manifestation glaucoma.Materials and methods: Patients included had a relatively recent manifestation of primary open-angle glaucoma. Patients with a minimum follow-up of 5 years and a minimum of seven VF tests were included. Statistical analysis was performed to verify the trend of variations in mean defect (MD) over time (PeriData). The results were subjected to a t-test for a comparative analysis of progression of VF changes over time. The annual rate of progression provided by PeriData considering all the VFs analyzed was compared with that obtained on half of the VF examinations during the same follow-up period. An analysis of the MD trend over time was also carried out in relationship to the number of VF tests done and by dividing the sample into a high-frequency group (more than eight VFs) and a low-frequency group (fewer than eight VFs) in the follow-up period.Results: A total of 96 eyes of 96 patients were included, and overall 846 VFs were examined. The paired t-test performed comparing the MD index of all the VFs against half of them did not show statistical significance (P=0.537). The high-frequency group comprised 39 eyes (average VF 11.05±1.91, average time interval 0.76 years) while the low-frequency group comprised 57 eyes (average VF 6.95±0.6, average time interval 1.21 years). The analysis of the MD trend in the high-frequency patients showed significance (P=0.017); the low-frequency group did not show statistical significance (P=0.08).Conclusion: The number of VFs in a determined time interval was not significant. However, a greater frequency of tests provides a predictive evaluation of the rate of progression of early manifestation open-angle glaucoma. Keywords: open-angle glaucoma, visual field, progression, ocular hypertensio

Le Beta-bloquant lévomoprolol dans le traitment du glaucome

Résumé : Les auteurs illustrent les résultats favorables obtenus chez 44 malades ave c glaucome à angle ouvert au moyen d'un nouveau béta-bloquant en collyre , le lévomoprolol. On a employé une solution à 2 %. administrée I à 3 fois par jour pendant une période de plus de 9 mois. Les paramètres pris en considération ont été: la tension oculaire , l'examen biomicroscopique du segment antérieur. la sécrétion Iacryrnale , la kérato-esthésie, la tension artérielle générale et la fréquence du pouls. On a pu mettre en évidence que Je médicament provoque une hypotension oculaire significative et durable , que sa tolérabilité locale est optimale et qu'il n'y a pas d'effets collatéraux systémiques

Therapeutic effectiveness of forskoline in chronic simple glaucoma

The AA., after a careful study of the former letterature, report the results of a clinical researche about the hypotensive action of the Forskolina in ophthalmic solution to the 0,50% and to the 1% in 41 persons affected with glaucoma and in 9 sound persons.The hypotensive answer obteined in both groups studied has been good; the Forskolina in solution to the 0,50% is resulted more effective than that to the 1