Thrombus Growth Under the Influence of Warfarin and After Abrupt Reversal of Its Effects

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67188/2/10.1177_000331976801900301.pd

Heart rate responses during treatment of hypertension with propranolol; The clinical usefulness of the nitroglycerin test

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116951/1/cpt1976194403.pd

Treatment Of Hypercholesterolemia With Aluminum Nicotinate*†

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111193/1/j.1532-5415.1962.tb03157.x.pd

The Relationship between Pulse Volume and Blood Flow in the Finger

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68062/2/10.1177_000331976701801001.pd

WITHDRAWAL OF ENDOGENOUS SYMPATHETIC DRIVE LOWERS BLOOD PRESSURE IN PRIMARY ALDOSTERONISM

We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid sinus nerve stimulation was discontinued, peripheral resistance and blood pressure increased. These data suggest that the sympathetic nervous system is important in the maintenance of hypertension in established primary aldosteronism.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73780/1/j.1365-2265.1981.tb00663.x.pd

Effect of phentolamine on platelet aggregation in patients with pheochromocytoma

Since exogeneous catecholamines potentiate ADP-induced aggregation in vitro, and this effect is blocked directly by phentolamine, it was assumed that platelets from patients with pheochromocytoma would be unusually sensitive to ADP and that this sensitivity would be reduced in the presence of phentolamine. Findings in four patients with pheochromocytoma were compared to results in 20 normals. Phentolamine had no immediate effect in either group. Pheochromocytoma platelets became more responsive to ADP after standing and this increase in responsiveness was inhibited by phentolamine. These results: 1) suggest that catecholamine concentrations in the plasma of patients with pheochromocytoma are not high enough to potentiate ADP aggregation and 2) may be explained by assuming that pheochromocytoma platelets are saturated with catecholamines.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21983/1/0000393.pd

Diminished finger volume pulse in borderline hypertension: Evidence for early structural vascular abnomality

Digital volume pulse during maximum dilation was determined in 27 patients with borderline essential hypertension (BHT) and 28 age-matched normotensive controls (NT). Finger pulse volume (PV) and finger systolic pressure (SBP) were measured by pneumoplethysmography during vasodilation induced by combining direct and reflex heat dilation and reactive hyperemia. Finger SBP was higher (p p -3). Pulse volume correlated inversely with SBP in BHT (r = -0.40, p < 0.05) but was unrelated to SBP in NT. Pulse volume was not altered by high or low sodium intake in BHT or NT despite significant changes in plasma renin activity (PRA). In BHT finger vessels are less distensible at a higher pressure than in NT. This abnormality is demonstrable during maneuvers to withdraw sympathetic tone and is not influenced by alteration of PRA. These data support the concept that BHT can produce structural vascular change, and demonstrate that this abnormality can be detected by a relatively simple method.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24137/1/0000394.pd

Contemporary antihypertensive therapy

Pharmacotherapy of human hypertension is effective, safe and well-tolerated. Antihypertensive drugs are of three broad classes: diuretics, sympatholytics and vasodilators. The use of each class is discussed and a summary of therapeutic considerations offered for representative agents. Recent trends in antihypertensive therapy are identified.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26517/1/0000055.pd

IN-VIVO AND IN-VITRO EFFECTS OF POLYVINYLPYRROLIDONE ON PLATELET ADHESIVENESS IN HUMAN BLOOD

Intravenous infusion of 500 ml. 6% polyvinylpyrrolidone (P.V.P. (Mw 40,000) in isotonic saline solution over a 2-hour period significantly diminished platelet adhesiveness in eight subjects from 27% before infusion to as low as 10% at the end of the infusion. 5 hours after the end of the infusion, platelet adhesiveness was still significantly reduced (16%). The addition of P.V.P. to citrated blood in vitro significantly decreased platelet adhesiveness. Both in vivo and in vitro, the platelet-count was not significantly altered by P.V.P. The in-vivo change in platelet adhesiveness is similar to that reported by others with dextran-a plasma expander that differs chemically from P.V.P.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33274/1/0000666.pd

EVIDENCE AGAINST AN INTERACTION OF ANGIOTENSIN II WITH THE SYMPATHETIC NERVOUS SYSTEM IN MAN

Animal experiments indicate that angiotensin II can, under some circumstances stimulate the sympathetic nervous system at a number of different sites. In order to determine whether such a relationship of the renin-angiotensin and sympathetic nervous system exists in man, we increased (by intravenous infusion), or decreased (by administering the oral converting enzyme inhibitor captopril) circulating angiotensin II levels and monitored plasma adrenaline and nor-adrenaline responses. Angiotensin II infusions did not increase plasma catechol-amines, and lowering of angiotensin II by captopril treatment in patients with severe hypertension or congestive heart failure failed to alter plasma adrenaline or nor-adrenaline levels. Whether physiological levels of angiotensin II are capable of interacting directly with the sympathetic nervous system in man remains to be demonstrated.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73600/1/j.1365-2265.1981.tb00684.x.pd