The Wrong Turn to Tijuana: Dry Beriberi after Gastric Bypass Surgery with Incidental Spinal Stenosis

Thiamine deficiency is a condition characterized by several different presentations, but one of the most devastating is dry beriberi. It is associated with polyneuropathy and muscle weakness which typically affects the lower extremities and progressively involves the upper extremities. This case outlines a case of a 41-year-old man that presented to the hospital with diffuse weakness and decreased sensation in his legs and hands over a 3-day period. The patient’s medical history revealed a gastric bypass surgery 4 months previously in Tijuana, Mexico, with no follow-up, binge drinking on weekends, and emesis in the past few weeks. A physical examination revealed a significant decrease in strength in the lower extremities bilaterally as well as in the hands bilaterally. MRI showed central disc protrusion at T6–T7 that indented the spinal cord, consistent with spinal stenosis. Neurosurgery was counseled and corpectomy was recommended. While awaiting surgery, a low thiamine level resulted. Neurology was consulted, and it was recommended that high-dose IV thiamine treatment be started. An EMG study further supported the diagnosis of thiamine deficiency. The patient received high-dose IV thiamine for 2 weeks and was discharged to acute rehabilitation on a high oral dose of thiamine. While at the rehabilitation facility, the patient continued to achieve functional gains and was later discharged to a skilled nursing facility, where he continues to make progress in his activities of daily living. This case serves to remind practitioners that early recognition and treatment of thiamine deficiency is imperative, especially when other clinical evidence may point to a different diagnosis

A cardiac rehabilitation program for breast cancer survivors: A feasibility study

Purpose: The purpose of this study was to determine the feasibility and preliminary efficacy of a cardiac rehabilitation (CR) intervention in the breast cancer population. Methods: This single-arm feasibility study evaluated a 14-week CR intervention program in breast cancer survivors. Feasibility was defined as completion of at least 30/36 sessions of the program without serious adverse events (SAE) in 80% of patients. Secondary endpoints included the change in VO2 max, cardiovascular disease (CVD) risk factors, Duke Activity Secondary Index (DASI), Brief Fatigue Inventory (BFI), and QLQ-C30. All outcomes were reported as mean change and compared using paired Results: A total of 25 patients were enrolled in the study. 18 patients of the 25 enrolled (72%) completed the 14 weeks program without SAE. The overall adherence to the study protocol was 60%. Of the 18 participants who did not withdraw from the program, 15 (83%) adhered to the study protocol and completed 30 or more sessions. There was a nonsignificant improvement in VO2 max (mean Δ0.5, Conclusion: A CR intervention in breast cancer survivors had high adherence in those who were able to complete the 14-week program. The program significantly improved patient reported physical activity, fatigue, and quality of life (QoL), without significant improvement in CVD risk factors. Implications for cancer patients are that early implementation of a CR program should be considered by practitioners as it improves QoL and exercise tolerance in breast cancer survivors