Status of Activities on Rehabilitation Of Radioactively Contaminated Facilities and the Site of Russian Research Center ''Kurchatov Institute''

This paper describes the program, the status, and the course of activities on rehabilitation of radioactively contaminated facilities and the territory of temporary radioactive waste (radwaste) disposal at the Russian Research Center ''Kurchatov Institute'' (RRC KI) in Moscow as performed in 2001-2002. The accumulation of significant amounts of radwaste at RRC KI territory is shown to be the inevitable result of Institute's activity performed in the days of former USSR nuclear weapons project and multiple initial nuclear power projects (performed from 1950's to early 1970's). A characterization of RRC KI temporary radwaste disposal site is given. Described is the system of radiation control and monitoring as implemented on this site. A potential hazard of adverse impacts on the environment and population of the nearby housing area is noted, which is due to possible spread of the radioactive plume by subsoil waters. A description of the concept and project of the RRC KI temporary radwaste disposal site is presented. Specific nature of the activities planned and performed stems from the nearness of housing area. This paper describes main stages of the planned activities for rehabilitation, their expected terms and sources of funding, as well as current status of the project advancement. Outlined are the problems faced in the performance and planning of works. The latter include: diagnostics of the concrete-grouted repositories, dust-suppression technologies, packaging of the fragmented ILW and HLW, soil clean-up, radioactive plume spread prevention, broad radiation monitoring of the work zone and environment in the performance of rehabilitation works. Noted is the intention of RRC KI to establish cooperation with foreign, first of all, the U.S. partners for the solution of problems mentioned above

COMBINATION THERAPY OF EROSIVE FORM OF GERD IN PATIENTS WITH THE MIXED CHARACTER OF RELUCTATE

The article presents the result of study of the effectiveness of a new drug dexlansoprazole in combination with the drug ursodeoxycholic acid in the group of patients with erosive esophagitis, with mixed reflux, as defined by results of 24-hour pHimpedance metering. Dynamics of clinical symptoms and endoscopic pattern when taking different doses of UDCA of primary and supportive therapy is monitored

Remediation of the high-level radwaste repositories at Russian Research Center “Kurchatov Institute”

The paper presents peculiarities of organization and performance of activities on disposition of the high level activity radwaste repository located at the radwaste disposal site of the Russian Research Center “Kurchatov Institute” in Moscow. The process of the radwaste extraction from the repository is described in comparison with similar activities in other old repositories. Tools and equipment used for the radwaste extraction from the repository are listed. Conventional construction machines equipped with a hydraulic hammer or a clamshell were used for destruction of the concrete-encased radwaste mass and extraction of low-level radwaste. Intermediate- and high-level radwaste was extracted by remotely controlled robots operating inside the shielding structure. Gamma visor was used for detection of high-level radwaste or fragments in the mass concrete being destroyed and for pointing remotely controlled robots accordingly. The paper describes peculiarities of radiation monitoring in the course of operations on disposition of the repository. For rapid detection of changes in radiation conditions in the working areas, there was used a gamma locator with on-line transmission of its data to a PC and their processing. The same measuring and extraction equipment were used for remediation of high-level radwaste repository at the Gas Plant complexes

CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC AMLODIPINE IN PATIENTS WITH MILD-TO-MODERATE ARTERIAL HYPERTENSION

Aim. To study clinical equivalence of two amlodipines under the control of their plasma levels and evaluate their pharmacoeconomical efficacy in patients with arterial hypertension (AH).Material and methods. 31 patient with AH were included in the study (14 men and 17 women). 21 (66 %) patients had AH of 1 stage and 10 (34 %) patients had AH of 2 stage. All patients were 39-81 y.o. (average - 60 y.o.) with AH duration 0,5-43 years (average - 17,9 years). Antihypertensive effect of Amlorus (Synthesis, Russia) and Norvasc (Pfizer, USA) was evaluated in the study. Blood pressure (BP), amlodipine plasma levels (by liquid chromatography with mass spectrometry) and side effects were registered before and after 2, 4 and 6 weeks of therapy. Hydrochlorothiazide 25 mg/d was added if the monotherapy with amlodipine10 mg/d had not been efficient. Therapy with the second studied amlodipine followed the therapy with the first drug.Results. Both drugs provided similar plasma amlodipine concentrations with significant BP reduction. 96,6 % and 90 % of patients reached BP target level (&lt;140/90 mm Hg) after 6 weeks of Amlorus and Norvasc therapy, respectively. Hydrochlorothiazide was needed in 23,3 % and 26,7 % of patients taking Amlorus and Norvasc, respectively. Cost of Amlorus therapy per patient was 221 rbl/month in comparison with cost of 727 rbl/month for Norvasc therapy.Conclusion. Generic Amlorus showed clinical and pharmacokinetic equivalency with an original amlodipine Norvasc and lower cost of therapy.</p

Heterodyne determination of the width of the emission lines of injection lasers in the beat frequency stabilization regime

A servo system was used to lock the beat frequency of injection lasers operating under conditions of self-stabilization of single-frequency emission in an anomalously wide continuous tuning range. The width of the beat spectrum was found to be ~500 Hz

Anomalously wide continuous tuning range of the emission frequency of an injection laser with an external selective resonator

A study was made of an anomalously wide continuous tuning range of the emission frequency of an injection laser with an external resonator operating under conditions of self-stabilized single-frequency lasing. The self-stabilization was observed for a large number of lasers with different structures, both at room and liquid nitrogen temperatures. A study was made of the influence of the power, degree of coupling with the external part of the laser, resonator length, and pass band of a selective component on the continuous tuning range. In the self-stabilization regime this range was 10-30 times greater than the corresponding range for a laser operating under conventional conditions. A nontrivial feature of hopping between longitudinal laser modes at the limit of the tuning range was observed. This feature was explained on the basis of a theory proposed by Bogatov, Eliseev, Okhotnikov, Rakhval'skii, and Khairetdinov [Sov. J. Quantum Electron. 13 , 1221 (1983)]